Search results for "riso"

Adaptive Modifications of Hypotheses After an Interim Analysis

2001

It is investigated how one can modify hypotheses in a trial after an interim analysis such that the type I error rate is controlled. If only a global statement is desired, a solution was given by Bauer (1989). For a general multiple testing problem, Kieser, Bauer and Lehmacher (1999) and Bauer and Kieser (1999) gave solutions, by means of which the initial set of hypotheses can be reduced after the interim analysis. The same techniques can be applied to obtain more flexible strategies, as changing weights of hypotheses, changing an a priori order, or even including new hypotheses. It is emphasized that the application of these methods requires very careful planning of a trial as well as a c…

Test and power considerations for multiple endpoint analyses using sequentially rejective graphical procedures

2009

A variety of powerful test procedures are available for the analysis of clinical trials addressing multiple objectives, such as comparing several treatments with a control, assessing the benefit of a new drug for more than one endpoint, etc. However, some of these procedures have reached a level of complexity that makes it difficult to communicate the underlying test strategies to clinical teams. Graphical approaches have been proposed instead that facilitate the derivation and communication of Bonferroni-based closed test procedures. In this paper we give a coherent description of the methodology and illustrate it with a real clinical trial example. We further discuss suitable power measur…

Costruire lo Stato, costruire la Nazione

2011

Il Risorgimento "tradito". Le lotte per la terra da Bronte ai Fasci siciliani

2012

Matematica e internazionalità nel carteggio fra Guccia e Cremona e nei Rendiconti del Circolo Matematico

Dall’esame del carteggio si evince la presenza di alcuni temi sopra gli altri: la descrizione della carriera scientifica e dei collegamenti internazionali di Guccia con relazioni dettagliate sui viaggi all’estero; i riferimenti al Circolo Matematico di Palermo, sin dalla prima fase della sua costituzione, e le acute valutazioni dell’ambito matematico europeo compiute da Guccia per garantire lo sviluppo internazionale del Circolo e dei Rendiconti.

Le scienze matematiche in Sicilia dal riformismo settecentesco all'unità nazionale

2012

Il Carteggio Cremona-Guccia (1878-1900)

2013

L'Analogie chez Aristote

2021

Revue de philosophie dont l’objet est de montrer, d’interroger ou d’évaluer les comparaisons effectives dans les différents champs disciplinaires, Analogia est une publication scientifique annuelle de l’IPC.Chaque numéro réunit un conseil scientifique nouveau chargé de sélectionner les contributions en double aveugle.L’Analogie chez Aristote.Sous la direction d’Emmanuel Brochier.Conseil scientifique :- Katerina Ierodiakonou (Genève – Athènes)- André Laks (Paris)- Benjamin C. Morison (Princeton)- Jean-Luc Solère (Boston)Sommaire :- Présentation, par Emmanuel Brochier, p. 5 ;- Christof Rapp : "Spotting similarities between disparate items" Observations on the use of analogy in Aristotle’s met…

Nonlinear Nonhomogeneous Elliptic Problems

2019

We consider nonlinear elliptic equations driven by a nonhomogeneous differential operator plus an indefinite potential. The boundary condition is either Dirichlet or Robin (including as a special case the Neumann problem). First we present the corresponding regularity theory (up to the boundary). Then we develop the nonlinear maximum principle and present some important nonlinear strong comparison principles. Subsequently we see how these results together with variational methods, truncation and perturbation techniques, and Morse theory (critical groups) can be used to analyze different classes of elliptic equations. Special attention is given to (p, 2)-equations (these are equations driven…

Measuring diversity. A review and an empirical analysis

2021

Abstract Maximum diversity problems arise in many practical settings from facility location to social networks, and constitute an important class of NP-hard problems in combinatorial optimization. There has been a growing interest in these problems in recent years, and different mathematical programming models have been proposed to capture the notion of diversity. They basically consist of selecting a subset of elements of a given set in such a way that a measure based on their pairwise distances is maximized to achieve dispersion or representativeness. In this paper, we perform an exhaustive comparison of four mathematical models to achieve diversity over the public domain library MDPLIB, …