Search results for "roche"
showing 10 items of 2666 documents
Electrophysiological and Neurochemical Characterization of 7-Nitroindazole and Molsidomine Acute and Sub-Chronic Administration Effects in the Dopami…
2009
Nitric oxide (NO) plays an important role in the integration of information processed by the basal ganglia nuclei. Accordingly, considerable evidence has emerged indicating a role for NO in pathophysiological conditions such as Parkinson’s disease (PD) and other neurodegenerative disorders. Despite these recent advances, the nitrergic modulation of the dopamine (DA) nigrostriatal system is still unclear. In order to fill this gap, in this study we used in vivo electrophysiology and ex vivo neurochemical analysis to further investigate the effect of NO signaling in rat substantia nigra pars compacta (SNc) and the striatum. Acute and subchronic (4 days) pharmacological manipulation of the NO …
Адсорбционные свойства диоксидномарганцевого электрода в водных растворах
1990
Advisor: Пурин, Бруно Андреевич ; Слайдинь, Гунар Янович ; Восекалнс, Александр Викторович
Практическое введеніе въ физическую химію и электрохимію
1922
Содержание: Глава I. Свойства газов 1. Определение молекулярного веса по плотности паров в прибор* Виктора Мейера 2. Скорость истечения газов и основанный на этом явлении метод определения плотности газов. Глава II. Свойства жидкостей 3. Критическая температура и критическая плотность жидких тел 4. Критическое давление 5. Плотность жидкостей 6. Вращение плоскости поляризации. Глава III. Разбавленные растворы 7. Понижение температуры замерзания растворов 8. Диссоциация солей в водных растворах 9. Повышене температуры кипения растворов 10. Светопереломляющая способность водных растворов. Глава IV. Химическая динамика 11. Скорость инверсии сахара 12. Катализ метиловоуксусного эфира 13. Скорост…
Room temperature ionic liquids based on cationic porphyrin derivatives and tetrakis(pentafluorophenyl)borate anion
2011
A series of 11 low melting ionic liquids based on meso-substituted A3B -porphyrins and A2B2-porphyrins containing one or two pyridyl substituents have been synthesized in high yields. Three of them are liquids at room temperature. All these porphyrinic salts were characterized by1H NMR,19F NMR, MALDI-TOF mass spectrometry, elemental analysis and UV-visible spectroscopy. The thermal properties and conductivity values of these salt derivatives have been also measured. A specific conductivity value of up to 4 mS.cm-1could be obtained for a compound having the counter-anion B(C6F5)4-.
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
V2O5 nanowires with an intrinsic peroxidase-like activity
2010
V2O5 nanowires exhibit an intrinsic catalytic activity towards classical peroxidase substrates such as 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 3,3,5,5,-tetramethylbenzdine (TMB) in the presence of H2O2. These V2O5 nanowires show an optimum reactivity at a pH of 4.0 and the catalytic activity is dependent on the concentration. The Michaelis-Menten kinetics of the ABTS oxidation over these nanowires reveals a behavior similar to that of their natural vanadium-dependent haloperoxidase (V-HPO) counterparts. The V2O5 nanowires mediate the oxidation of ABTS in the presence of H2O2 with a turnover frequency (k(cat)) of 2.5 x 10(3) s(-1). The K-M values of the V2O5 nanowire…
PEDAGOGIA DELL'ATTENZIONE
2011
Il libro è proposto come introduzione filosofica e pedagogica alla vita interiore, piccolo manuale di idee ad uso degli educatori. È strutturato in testi brevi, che fanno ventisei capitoli, ordinati in tre parti. Nella prima, quella filosofica in senso proprio, sono giustificate le verità che essere-amato è l'ontologia della persona e che l'essere dello spirito è relazionalità in senso eminente: è essenza stessa della vita interiore il dialogo ininterrotto con quanto di prezioso è custodito nel cuore, i suoi amori e l'ordine secondo il quale si dispongono. La seconda parte, quella pedagogica in senso adeguato, intende l'educazione come una qualità speciale, la cui conquista dota la persona …
Impact of hydroxy and octyloxy substituents of phenothiazine based dyes on the photovoltaic performance
2013
Two novel organic dyes containing hydroxy and octyloxy substituents onto a phenothiazine skeleton were synthesized and their effects on the photovoltaic performance were studied. Hydroxy acts as an ancillary anchoring unit along with the carboxylic group, while the phenothiazine modified moiety acts as an electron donor. The photophysical and electrochemical studies revealed that maximum absorbance of the dye with the hydroxy group in the solution was blue shifted and its band gap increased, indicating that donor acceptor strength was reduced as compared to the octyloxy substituted dye. Furthermore, electron lifetime of the organic dye with the hydroxy moiety was shorter due to smaller resi…
Polypyrrole films functionalized with pendant titanocene dichloride complexes: Ellipsometric study of the electropolymerization process
2007
Electrochemical and ellipsometric methods have been used to study the electropolymerization process of a functionalized monomer, Tc3Py (in which pyrrole is covalently bonded with titanocene dichloride complex) on platinum electrode from a dilute monomer solution in acetonitrile. The deposition has been performed in the potentiodynamic regime. A new method for the acquisition and treatment of ellipsometric data has been proposed which allowed us to analyze the evolution of the film properties at each potential. The model of a single uniform layer was unable to describe the ellipsometric experimental observations with the necessary precision. A proper fitting of the data has been achieved con…
Lanthanide–saccharide chemistry: synthesis and characterisation of Ce(III)–saccharide complexes
2000
A series of nine Ce(III) complexes has been synthesised with seven different monosaccharides (D-glucose, D-fructose, D-galactose, D-mannose, L-sorbose, D-ribose and D-xylose) and two different disaccharides (D-maltose and L-lactose), and these have been characterised with various analytical, spectral, magnetic and electrochemical techniques. The NMR studies have highlighted some interesting features about the metal-ion-binding pattern of the saccharides. Some additional coordination has been proposed along with the chelating groups in the saccharide molecules, based on the shifts in 13C NMR spectra. On the other hand, solution absorption studies and solid-state magnetic susceptibilities hav…