Search results for "stroke"

Führt hochdosiertes Dipyridamol in der sekundären Schlaganfallprävention zu kardialen Ereignissen?

2001

In einer post-hoc Analyse der European Stroke Prevention Study 2 (ESPS2) wurde untersucht, ob die Gabe von Dipyridamol als Thrombozytenfunktionshemmer bei Patienten mit TIA oder Schlaganfallen das Risiko kardialer Ereignisse erhoht. ESPS2 war eine Sekundarpraventionsstudie an 6602 Patienten nach TIA oder ischamischem Insult, die in vier Armen Acetylsalicylsaure (ASS, 2×25 mg), retardiertes Dipyridamol (DP, 2×200 mg), die Kombination aus ASS plus DP oder Placebo verglich. Es ergaben sich keine Anhaltspunkte dafur, dass DP zu vermehrten kardialen Ereignissen (Angina pectoris, Myokardinfarkt, Tod) fuhrt. Die Kombination aus ASS und DP war allerdings in der Schlaganfallpravention deutlich wirks…

Schlaganfallversorgung in der Prähospitalphase

2003

In westlichen Industrienationen ist der Schlaganfall die dritthaufigste Todesursache und die haufigste Ursache fur erworbene Behinderungen uberhaupt. Optimale Behandlungsbedingungen bestehen nur dann, wenn die Fruhsymptome des Schlaganfalls rechtzeitig erkannt werden und die Behandlung innerhalb von 3 h nach Einsetzen der Erstsymptome eingeleitet wird. Eine „Rettungskette des Schlaganfalls” muss deshalb Konzepte zur Fruherkennung, eine rasche prahospitale Versorgung gefolgt von effizienter Diagnostik und eine unmittelbar einsetzende Akuttherapie sinnvoll integrieren. Der vorliegende Beitrag hat zum Ziel, diesen Ansatz unter besonderer Berurcksichtigung der prahospitalen Phase darzustellen. …

Repetitive use of LEvosimendan in Ambulatory Heart Failure patients (LEIA-HF) - The rationale and study design

2022

Abstract Purpose Clinical practice forces the necessity to conduct a clinical trial concerning the group of outpatients with chronically advanced heart failure in III or IV NYHA functional class, frequently requiring hospitalizations due to HF exacerbation, and often left without any additional therapeutic option. The current trial aims to determine the efficacy and safety of repeated levosimendan infusions in the group of severe outpatients with reduced ejection fraction (HFrEF). Material and methods LEIA-HF (LEvosimendan In Ambulatory Heart Failure Patients) is a multicentre, randomized, double-blind, placebo-controlled, phase 4 clinical trial to determine whether the repetitive use of le…

Evaluation of a novel biomarker of type XXVIII collagen formation, PRO-C28, in samples from cancer and heart failure with preserved ejection fraction…

2020

Increased turnover of extracellular matrix proteins is seen in many different diseases and is an underlying and driving feature of pathogenesis. An increased ratio of formation over degradation of extracellular matrix proteins, such as collagens, leads to accumulation of proteins in the tissues, ultimately impairing organ function. Understanding how this balance is regulated is key to providing deeper insight into high extracellular matrix turnover diseases. Type XXVIII collagen is a novel collagen with limited information available in relation to expression, tissue prevalence and clinical implication. We generated a novel, technically robust ELISA to measure a C-terminal fragment of type X…

Beyond left ventricular ejection fraction there is a right heart that pumps.

2017

Chronotropic Incompetence Predicts Distance Walked in Six-Minute Walk Test in Heart Failure With Preserved Ejection Fraction

2020

Role of functional mitral regurgitation in heart failure with preserved ejection fraction: an unrecognized protagonist?

2016

What Is the Role of Minimally Invasive Mitral Valve Surgery in High-Risk Patients? A Meta-Analysis of Observational Studies

2016

Background. Minimally invasive valve surgery is related to certain better postoperative outcomes. We aimed to assess the role of minimally invasive mitral valve surgery in high-risk patients. Methods. A systematic literature review identified eight studies of which seven fulfilled criteria for metaanalysis. Outcomes for a total of 1,254 patients (731 were conventional standard sternotomy and 523 were minimally invasive mitral valve surgery) were submitted to meta-analysis using random effects modeling. Heterogeneity and subgroup analysis with quality scoring were assessed. The primary end point was early mortality. Secondary end points were intraoperative and postoperative outcomes and long…

Post-rehabilitation home exercises after stroke and hip fracture: results of a pilot study in Palermo

2010

Although most patients having sustained a stroke or hip fracture (PSHF) attend a period of therapy and rehabilitation program, it usually only last a few months and they may not continue an exercise program when the rehabilitation treatment has ended. Many Authors suggests that PSHF can improve or maintain the rehabilitation outcomes through an exercise program. At the geriatric assessment and integrated home-care Unit, Health-District 10, ASP6-Palermo, we enrolled 51 PSHF who were able to collaborate and follow the home exercise program and compared them with 50 PSHF who had been discharged from the same Unit in the period preceding the beginning of the study. The home exercise program was…

Analgesic hypnotic treatment in a post-stroke patient

2021

In recent years, hypnotic suggestions have been used in several clinical conditions. This treatment is often used for anxiety treatment, somatization, and post-traumatic stress disorder. Hypnotic analgesia is one of the most clinically useful phenomena of hypnosis. The article describes the case of a patient who underwent hypnotic treatments for hypersensitivity and chronic pain. Results showed an improvement of pain control and a decrease of pain hypersensibility. In addition, during rehabilitative treatments, the patient reported a high level of compliance with the multidisciplinary team. These findings suggest that hypnosis could be a useful treatment for post-stroke pain management.