Search results for "stroke"

In vivo and ex vivo magnetic resonance spectroscopy of the infarct and the subventricular zone in experimental stroke

2015

Ex vivo high-resolution magic-angle spinning (HRMAS) provides metabolic information with higher sensitivity and spectral resolution than in vivo magnetic resonance spectroscopy (MRS). Therefore, we used both techniques to better characterize the metabolic pattern of the infarct and the neural progenitor cells (NPCs) in the ipsilateral subventricular zone (SVZi). Ischemic stroke rats were divided into three groups: G0 (non-stroke controls, n = 6), G1 (day 1 after stroke, n = 6), and G7 (days 6 to 8 after stroke, n =12). All the rats underwent MRS. Three rats per group were analyzed by HRMAS. The remaining rats were used for immunohistochemical studies. In the infarct, both techniques detect…

Acute Stroke Care during COVID-19: National Data.

2022

(1) Background: The pandemic of COVID-19 and subsequent lockdown strategies had a profound impact on many aspects of everyday life. During this time the world faced the unprecedented crisis of healthcare disrupting timely care delivery. This study was designed to evaluate the impact of the pandemic on the acute treatment of stroke in Poland. (2) Methods: The national data on hospitalizations with stroke as a primary diagnosis were obtained from the National Health Fund of Poland. Poisson regression was used to determine the significance of the change in hospital admissions. The differences between proportions were analyzed using the “N-1” Chi-squared test. (3) Results: During the COVID-19 p…

The metabolic syndrome-arterial stiffness relationship in patients with ischaemic stroke: role of inflammation

2008

Ischemic Stroke Pathogenesis: Genetics, Epigenetics and Inflammation

2020

Inflammation as a therapeutic target in acute ischemic stroke treatment.

2009

Animal models of focal ischaemia induced by middle cerebral artery occlusion (MCAO) provide most evidence for cellular inflammatory responses in stroke. Permanent MCAO results in a modest neutrophil infiltration at 24 h after ischaemia, predominantly around arterial vessels at the margins of infarction, whereas MCAO with subsequent reperfusion is associated with substantial infiltration by neutrophils throughout the entire infarct. Several studies show that C-reactive protein (CRP), an inflammatory marker, is associated with stroke outcomes and future vascular events. Several drugs, especially hydroxymethylglutaryl coenzyme A reductase inhibitors (statins), have been demonstrated to reduce …

Editorial ischemic stroke pathogenesis: Genetics, epigenetics and inflammation

2020

Microglial and BDNF impact on the induction of the post ischemic neuroplasticity

2011

Evidences showing that under certain circumstances, inflammatory response could be neuroprotective and could also promote adult neurogenesis are growing. In this context, the objective of this work was to investigate the impact of microglial cells in the neuroplastic events. Rats were subjected to photothrombotic ischemia and microglial cells activation was blocked by the mean of poly(ADP-ribose)polymérase-1 (PARP-1) inhibition using 3- aminobenzamide (3-AB) since this protein has been shown to play a major role in this activation. Our results show that PARP-1 activity reduction was associated with a strong repression of the acute microglial activation. Beside, 3-AB treated animals exhibite…

Inflammation and Inflammatory Cell Recruitment in Acute Cerebrovascular Diseases

2015

Inflammation seems to play a major role in the pathogenesis of ischemic stroke as well as in other forms of brain damage. Ischemic brain injury induces a strong inflammatory response that begins in the microcirculation and involves several cell types and molecules, leading to neuronal death. The immune system is actively involved in the pathogenesis of acute brain damage through a set of events that include leukocyte and monocyte infiltration into the brain, activation of resident cells, including microglia, astrocytes and endothelial cells, and the elevated production of several inflammatory molecules, such as cytokines, that together play a complex role in the pathophysiology of ischemic …

Commentary: Circulating cytokines and risk stratification of stroke incidence--will we do better in future?

2008

Comparing Translation and Post-editing: An Annotation Schema for Activity Units

2016

The current chapter introduces an annotation schema of TPR data that categorises post-editing behaviour into five different classes and compares general-language and domain-specific English-to-German translation and post-editing with respect to production times, key-logging (text production activity and text elimination activity) and eye-tracking data (total reading times on source text and on target text). The results support the hypothesis that post-editing is faster than translation from scratch for both domain-specific and non-domain-specific text types. When key-logging and eye-tracking data are taken into consideration, domain-specific texts require more effort when translating from s…