Search results for "target"

Engineering design and steady state thermomechanical analysis of the IFMIF European lithium target system

2013

In the framework of the current IFMIF Engineering Validation and Engineering Design Activities (IFMIF/EVEDA) phase, ENEA is responsible for the design of the European concept of the IFMIF lithium target system which foresees the possibility to periodically replace only the most irradiated and thus critical component (i.e., the backplate) while continuing to operate the rest of the target for a longer period (bayonet backplate concept). In this work, the results of the steady state thermomechanical analysis of the IFMIF EU target assembly are briefly reported highlighting the relevant indications obtained with respect to the fulfillment of the design requirements. © 2013 IEEE.

Comparative Analysis of Four New Alternative Types of Roundabouts: “Turbo”, “Flower”, “Target” and “Four-Flyover” Roundabou

2016

Analysis of literature shows that “modern roundabouts” nowadays exist in all European countries, as well as in more than 60 countries elsewhere in the world. Nowadays, a growing number of studies, presented in scientific and professional literature, point out a poor traffic safety characteristics of “standard” two-lane roundabouts and lower capacity then was expected. These problems are resolved in more ways in different countries; however the solution, whereby the number of conflict spots is diminished has proven to be the most successful. Lower number of conflict spots is one of characteristics of the alternative types of roundabouts. The alternative types of roundabouts are usually more …

As much English as possible : A study on two secondary school English teachers language use and the motives behind their language choices

2009

 Kommunikatiivisen kompetenssin ja suullisen kielitaidon painoarvo vieraiden kielten oppimisessa ja opettamisessa on kasvanut viime vuosina, mikä on lisännyt huomiota myös opettajien kielenkäyttöön. Tämän proseminaaritutkimuksen tarkoituksena oli selvittää, minkä verran englannin opettajat käyttävät tunneillaan englantia ja suomea ja miten he perustelevat kielivalintojaan. Taustana käytettiin teoreettista keskustelua kohdekielen ja äidinkielen hyödyistä kohdekielen oppimisen kannalta sekä aiempia tutkimustuloksia opettajien kielenkäytöstä. Tutkimuksen aineisto koostui kahdesta videokuvatusta kahdeksannen luokan englannin tunnista ja tunnit pitäneiden opettajien haastatteluista. Toisella ope…

Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature

2015

Despite massive investments in drug research and development, the significant decline in the number of new drugs approved or translated to clinical use raises the question, whether single targeted drug discovery is the right approach. To combat complex systemic diseases that harbour robust biological networks such as cancer, single target intervention is proved to be ineffective. In such cases, network pharmacology approaches are highly useful, because they differ from conventional drug discovery by addressing the ability of drugs to target numerous proteins or networks involved in a disease. Pleiotropic natural products are one of the promising strategies due to their multi-targeting and d…

Colorectal cancer defeating? Challenge accepted!

2013

Colorectal tumours are actually considered as aberrant organs, within it is possible to notice a different stage of cell growth and differentiation. Their origin is reported to arise from a subpopulation of tumour cells endowed with, just like the healthy stem cells, self-renewal and aberrant multi-lineage differentiation capacity likely to be called colorectal cancer stem cells (CCSCs). Cancer stem cells (CSCs) fate, since their origin, reflects the influences from their microenvironment (or niche) both in the maintenance of stemness, in promoting their differentiation, and in inducing epithelial-mesenchymal transition, responsible of CSCs dissemination and subsequent formation of metastat…

Isolation and characterization of a cDNA encoding rat liver cytosolic epoxide hydrolase and its functional expression in Escherichia coli.

1993

A cDNA of 1992 base pairs encoding the complete rat liver cytosolic epoxide hydrolase has been isolated using a polymerase chain reaction-derived DNA fragment (Arand, M., Knehr, M., Thomas, H., Zeller, H. D., and Oesch, F. (1991) FEBS Lett. 294, 19-22) known to represent the 3'-end of the cytosolic epoxide hydrolase mRNA. Sequence analysis revealed an open reading frame of 1662 nucleotides corresponding to 554 amino acids (M(r) = 62,268). The DNA sequence obtained did not display significant homology to the sequences of microsomal epoxide hydrolase or leukotriene A4 hydrolase or to any other DNA included in the EMBL Data Bank (release 32). On Northern blotting of rat liver RNA, a single mRN…

Differential subcellular localization of endogenous and transfected soluble epoxide hydrolase in mammalian cells: evidence for isozyme variants

1999

AbstractEndogenous, constitutive soluble epoxide hydrolase in mice 3T3 cells was localized via immunofluorescence microscopy exclusively in peroxisomes, whereas transiently expressed mouse soluble epoxide hydrolase (from clofibrate-treated liver) accumulated only in the cytosol of 3T3 and HeLa cells. When the C-terminal Ile of mouse soluble epoxide hydrolase was mutated to generate a prototypic putative type 1 PTS (-SKI to -SKL), the enzyme targeted to peroxisomes. The possibility that soluble epoxide hydrolase-SKI was sorted slowly to peroxiosmes from the cytosol was examined by stably expressing rat soluble epoxide hydrolase-SKI appended to the green fluorescent protein. Green fluorescent…

The Fourth ACM SIGSPATIAL Workshop on Location-Based Recommendations, Geosocial Networks and Geoadvertising

2021

The amount of publicly available geo-referenced data has seen a dramatic increase over the last years. Many user activities generate data that are annotated with location and contextual information. Moreover, it has become easier to collect and combine rich and diverse location information. In the context of geoadvertising, the use of geosocial data for targeted marketing is receiving significant attention from a wide spectrum of companies and organizations. With the advent of smartphones and online social networks, a multi-billion dollar industry that utilizes geosocial data for advertising and marketing has emerged. Geotagged social-media posts, GPS traces, data from cellular antennas and…

Development of a Tumor-Derived Extracellular Vesicle Engineering Protocol for Targeted Chemotherapeutic: A Novel Experimental Model using Malignant P…

2023

The Interplay between Money Market Development and Changes in Monetary Policy Operations in Small European Countries, 1980-2000

2006

We study the interplay between money market development and changes in monetary policy operating procedures in 11 European countries from c. 1980 up to the launch of the EMU. Aspects of money market development such as size and structure of different market segments, and institutional and regulatory changes, are addressed. We recount and empirically examine the reorientation of monetary policy instruments away from quantitative direct control instruments towards indirect market-based instruments.The process of deregulation is uniform across countries. The path of money market development varies substantially, whereas changes in central bank instruments show both similarities and differences…