Search results for "tea"

Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis

2018

Abstract: Chemotherapy is currently the only effective approach to treat all forms of leishmaniasis. However, its effectiveness is severely limited due to high toxicity, long treatment length, drug resistance, or inadequate mode of administration. As a consequence, there is a need to identify new molecular scaffolds and targets as potential therapeutics for the treatment of this disease. We report a small series of 1,2‐substituted‐1H‐benzo[d]imidazole derivatives (9ad) showing affinity in the submicromolar range (Ki = 0.150.69 μM) toward Leishmania mexicanaCPB2.8ΔCTE, one of the more promising targets for antileishmanial drug design. The compounds confirmed activity in vitro against intrace…

Mentoring of newly qualified teachers. A bilateral comparison between Germany and Finland

2017

Mentoring stellt in der Begleitung von in den Beruf einsteigenden Lehrpersonen eine international gängige Praxis dar. Ausgehend von theoretischen und empirisch fundierten Annahmen wird in diesem Beitrag der Ansatz der practice architectures genutzt, um Formen des Mentorings in Deutschland und Finnland im Hinblick auf länderspezifische Verständnisse vom Berufseinstieg von Lehrpersonen und deren Professionalisierung zu untersuchen. (DIPF/Orig.) Internationally, mentoring is a well-recognized practice in supporting newly qualified teachers. Based on theoretical and empirical understanding, this paper compares mentoring practices in two countries: Germany and Finland. The theoretical framework …

Verso una nuova cultura di Bildung: l’approccio biografico-narrativo come metodologia formativa

2020

Teoria e prassi, azione e riflessione, oggetto e soggetto, cura d’altri e cura di sé, sono i pilastri di una pedagogia volta alla Bildung intesa come tensione spirituale dell’io e coscienza di una crescita interiore cui ogni uomo può e deve elevarsi alla sua vera condizione umana. Questo lavoro si divide in due parti: la prima parte è volta a delineare una ricostruzione storica del concetto di Bildung, soffermandosi principalmente sul senso e sul significato che Edith Stein ha offerto al mondo della pedagogia; nella seconda parte del lavoro, si vuole identificare l’importanza di adottare la tecnica riflessiva della narrazione autobiografica per far emergere la validità che essa possiede nel…

Expert video exchanges in bilingual biology lessons - student’s intrinsic motivation and subject-specific interest

2019

This paper presents an instructional model to incorporate English-language communication between international practicing scientists and English learners into secondary science lessons. The aim was...

Tiempos de Cruzada

1998

Uczenie poezji amerykańskiej i niemieckiej przez przekład na przykładzie wybranych utworów literackich

2019

Not only is translation of poetry an effective method of teaching poerty in a proper historical context, but also it enhances students acquisition of knowledge about realities of life in foreign countries and different cultures, not to mention the fact that it improves their linguistic competences in both the source and the target languages. What is important, translation is a holistic method, forcing students to think independently.

Isolation of the Endothelin B Receptor from Bovine Lung Structure, Signal Sequence, and Binding Site

1995

Bovine lung endothelin-B receptor has been isolated in good yield with a new procedure involving the use of endothelin-1 coupled to iminobiotin with a long spacer and avidin-agarose affinity chromatography. Contrary to previous reports, evidence has been obtained that the native form of this receptor corresponds to the full-length transcript expected on the basis of cDNA clones. The binding of endothelin to a variety of shortened fragments of the full receptor suggests that the long N-terminal sequence of this receptor has very little influence on the binding of endothelin and that the main determinants of the endothelin binding site might be constituted by residues in the sixth, and possib…

Non-Enzymatic Water-Soluble Antioxidants Bioanalysis in Some Teas and Juices by PCL Method

2011

Non-enzymatic water-soluble antioxidants from different teas (black, green, peppermint), coffee, natural extract of rosemary and fruit juices (apple, grape, grapefruit, kiwifruit) were quantized by measuring their chemiluminescence in order to establish their power to protect the living beings from the free radicals. Among the samples high values of antioxidative capacity presents green tea (655 mmol AU) (AU=ascorbic units) and kiwi fruit juice (31 mmol AU). The maximum measuring times are less than 3 minutes. The sensivity of the photo-induced chemiluminescence (PCL) method was very high: nanomolar concentrations of non-enzymatic watwer-soluble antioxidative substances, as ascorbic acid un…

Enhancing methane production from lignocellulosic biomass by combined steam-explosion pretreatment and bioaugmentation with cellulolytic bacterium

2017

Background Biogas production from lignocellulosic biomass is generally considered to be challenging due to the recalcitrant nature of this biomass. In this study, the recalcitrance of birch was reduced by applying steam-explosion (SE) pretreatment (210 °C and 10 min). Moreover, bioaugmentation with the cellulolytic bacterium Caldicellulosiruptor bescii was applied to possibly enhance the methane production from steam-exploded birch in an anaerobic digestion (AD) process under thermophilic conditions (62 °C). Results Overall, the combined SE and bioaugmentation enhanced the methane yield up to 140% compared to untreated birch, while SE alone contributed to the major share of methane enhancem…

A hydrodynamic water quality model for propagation of pollutants in rivers.

2010

Numerical modelling can be a useful tool to assess a receiving water body's quality state. Indeed, the use of mathematical models in river water quality management has become a common practice to show the cause-effect relationship between emissions and water body quality and to design as well as assess the effectiveness of mitigation measures. In the present study, a hydrodynamic river water quality model is presented. The model consists of a quantity and a quality sub-model. The quantity sub-model is based on the Saint Venant equations. The solution of the Saint Venant equations is obtained by means of an explicit scheme based on space-time conservation. The method considers the unificatio…