Search results for "toc"
showing 10 items of 14693 documents
The swinholide biosynthetic gene cluster from a terrestrial cyanobacterium Nostoc sp. UHCC 0450
2018
Swinholides are 42-carbon ring polyketides with a 2-fold axis of symmetry. They are potent cytotoxins that disrupt the actin cytoskeleton. Swinholides were discovered from the marine sponge Theonella sp. and were long suspected to be produced by symbiotic bacteria. Misakinolide, a structural variant of swinholide, was recently demonstrated to be the product of a symbiotic heterotrophic proteobacterium. Here, we report the production of swinholide A by an axenic strain of the terrestrial cyanobacterium Nostoc sp. strain UHCC 0450. We located the 85-kb trans-AT polyketide synthase (PKS) swinholide biosynthesis gene cluster from a draft genome of Nostoc sp. UHCC 0450. The swinholide and misaki…
Transcatheter arterial chemoembolization for hepatocellular carcinoma in cirrhosis;survival rate and prognostic factors
2010
Background: The role of prognostic variables in the treatment of hepatocellular carcinoma (HCC) by transarterial chemoembolisation (TACE) is controversial. Aims: To evaluate the survival of patients with HCC on cirrhosis treated with TACE and to analyse the prognostic factors affecting survival. Methods: From 1996 to 2006, 580 consecutive patients with HCC in cirrhosis were observed. Of these 194 patients underwent TACE. The primary end-point was survival. Independent predictors of survival were identified using the Cox model. Results: The cumulative 1-year, 3-year, and 5-year survival rates were 96%, 60%, and 41%, respectively. The multivariate analysis showed significant reduction of surv…
Tumor-derived exosomes as factors that promote metastatic niche formation: evaluation of the effects induced by colon cancer derived exosomes on func…
2023
Minimizing fleet operating costs for a container transportation company
2006
Abstract This paper focuses on a fleet management problem that arises in container trucking industry. From the container transportation company perspective, the present and future operating costs to minimize can be divided in three components: the routing costs, the resource (i.e., driver and truck) assignment costs and the container repositioning costs (i.e., the costs of restoring a given container fleet distribution over the serviced territory, as requested by the shippers that own the containers). This real-world problem has been modeled as an integer programming problem. The proposed solution approach is based on the decomposition of this problem in three simpler sub-problems associate…
Influencia del tratamiento radiológico locorregional pretrasplante en la evolución de los pacientes trasplantados por cirrosis hepática con carcinoma…
2015
El carcinoma hepatocelular (CHC) es el tumor maligno hepático primario más frecuente y representa la tercera causa de cáncer en el mundo. Su incidencia está aumentando considerablemente en las últimas décadas1. Este tumor se desarrolla habitualmente sobre hígados cirróticos y la resección quirúrgica sólo es posible en menos del 30% de los casos2. El trasplante hepático (TH) es el único tratamiento potencialmente curativo y su realización en pacientes con carcinoma hepatocelular que cumplen criterios de Milán3 está plenamente aceptado4, avalado por sus buenos resultados a largo plazo5,6. Cuando se cumplen estos criterios, la tasa de supervivencia a los 5 años después del trasplante es del 70…
Trastornos obsesivo-compulsivo: creencias, conocimientos y estigma en el ámbito docente
2014
El trastorno obsesivo-compulsivo (TOC) está catalogado como un trastorno caracterizado por dos síntomas que otorgan el nombre de la patología; las obsesiones y las compulsiones. A pesar de la existencia de tratamientos eficaces, en muchas ocasiones, el trastorno no se reconoce, y en consecuencia, no se trata. La falta de conocimiento (por ejemplo, pobre alfabetización en salud mental (Mental Health Literacy)) sobre el trastorno obsesivo-compulsivo en el ámbito docente puede ser un impedimento para la búsqueda de ayuda profesional y tratamientos, y la consecuente cronificación del trastorno. Objetivos: El presente estudio intenta evaluar el conocimiento, las creencias y el estigma asociado a…
ESSAI RANDOMISÉ POUR ÉVALUER L’EFFICACITÉ ET LA SÉCURITÉ DE TRAITEMENTS CHEZ DES PATIENTS AMBULATOIRES ATTEINTS DE COVID-19 AYANT DES FACTEURS DE RIS…
2021
Context. The Covid-19 pandemic is of unprecedented magnitude and has had major social and health consequences. Primary care professionals, mainly general practitioners, ensure the care of most patients with Covid-19. An early-stage treatment administered to patients with risk factors for developing a severe disease could reduce hospitalization and death rates. No treatment is currently validated in this indication. Objectives. To evaluate the safety and efficacy of experimental candidate agents delivered in outpatient settings to reduce the risk of hospitalization or death in at-risk patients with early-stage proven Covid-19 and no indication for hospital admission. Methods. Multicentric, o…
Survival trends for primary liver cancer, 1995–2009: analysis of individual data for 578,740 patients from 187 population-based registries in 36 coun…
2019
CONCORD Working Group Members: Africa—Algeria: S Bouzbid (Registre du Cancer d’Annaba); M Hamdi-Chérif*, Z Zaidi (Registre du Cancer de Sétif); Gambia: R Swaminathan (National Cancer Registry); Lesotho: SH Nortje (Children’s Haematology Oncology Clinics - Lesotho); Libya: MM El Mistiri (Benghazi Cancer Registry); Mali: S Bayo, B Malle (Kankou Moussa University); Mauritius: SS Manraj, R Sewpaul-Sungkur (Mauritius National Cancer Registry); Nigeria: A Fabowale, OJ Ogunbiyi* (Ibadan Cancer Registry); South Africa: D Bradshaw, NIM Somdyala (Eastern Cape Province Cancer Registry); DC Stefan (Umtata University); Tunisia: L Jaidane, M Mokni (Registre du Cancer du Centre Tunisien). America (Central…
Producción de blastocistos diploides, heteroparentales a partir de pre-embriones tripronucleareshumanos procedentes de FIV e ICSI
2015
En Biomedicina, particularmente en el campo de reproducción humana asistida, la mejora de las técnicas implícitas, así como la puesta a punto de otras, requiere de la realización de estudios y ensayos previos con pre-embriones, preferiblemente de la misma especie, con potencial de desarrollo y que sean genéticamente normales. La disponibilidad y uso de estos pre-embriones no debe provocar conflictos éticos ni legales, no siendo, los pre-embriones humanos generados con una finalidad reproductiva la opción más inmediata. En la búsqueda de modelos pre-embrionarios humanos válidos, homólogos a aquéllos reproductivamente viables, presentamos el presente trabajo de tesis, cuyo objetivo principal …
Randomized Trial : D-Glyceric Acid Activates Mitochondrial Metabolism in 50–60-Year-Old Healthy Humans
2021
Background: Based on earlier studies, natural metabolite D-glyceric acid (DGA) does not seem to play any role in whole-body metabolism. Nevertheless, one ethanol oxidation-related rat study with controversial results raised our interest. According to preparatory studies for the regulatory approval of DGA, some highly conserved mechanism seems to subtly activate the cellular energy metabolism. Therefore, the present 25-days double-blind human study with placebo control was initiated. Purpose: The main target in the present study with 27 healthy 50–60-year-old human volunteers was to find out whether an “acute” 4-days and a longer 21-days exogenous DGA regimen caused moderate activation of th…