Search results for "traumat"
showing 10 items of 446 documents
Applying univariate vs. multivariate statistics to investigate therapeutic efficacy in (pre)clinical trials: A Monte Carlo simulation study on the ex…
2020
BackgroundSmall sample sizes combined with multiple correlated endpoints pose a major challenge in the statistical analysis of preclinical neurotrauma studies. The standard approach of applying univariate tests on individual response variables has the advantage of simplicity of interpretation, but it fails to account for the covariance/correlation in the data. In contrast, multivariate statistical techniques might more adequately capture the multi-dimensional pathophysiological pattern of neurotrauma and therefore provide increased sensitivity to detect treatment effects.ResultsWe systematically evaluated the performance of univariate ANOVA, Welch's ANOVA and linear mixed effects models ver…
PTSD symptoms in children and adolescents 28 months after a flood: age and gender differences.
2007
The present study examined the prevalence and predictors of posttraumatic stress disorder symptoms (PTSD) in a sample of 533 students (aged 11 to 21), 28 months after the 1997 Flood in southwestern Poland. The results show that 18% of the participants met all diagnostic criteria for PTSD. Based on hierarchical multiple regression analyses, PTSD criteria symptoms were positively correlated with the degree of exposure to trauma experienced during the disaster. A three-way interaction of trauma, age, and gender showed that more PTSD symptoms were observed among the younger participants and girls than among the older boys. The results confirm the need of research testing culturally sensitive im…
Responsability in management of the early stages in clinical evaluation of oral-facial traumatic events
2019
Obiettivi Scopo del presente lavoro è esaminare gli eventi traumatici oro-facciali e i loro effetti e individuare linee e schemi comportamentali e un linguaggio clinico e medico-legale appropriato che aiutino a identificare con immediatezza l’evento traumatico e i suoi postumi, e una corretta gestione dello stesso, in modo consono alle esigenze assicurative e/o giudiziarie, oltre che strettamente cliniche. Si vuole, inoltre, sottolineare l’importanza clinica e medico-legale della prima visita. Materiali e metodi I diversi aspetti dell’argomento sono esaminati sia da un punto di vista clinico che medico legale. Attraverso l’analisi delle diverse tipologie di trauma e degli schemi procedurali…
Survival of occlusal ART restorations in primary molars placed in school environment and hospital dental setup-one year follow-up study
2010
Objective: The objectives of this clinical study were to: evaluate the survival of occlusal atraumatic restorative treatment (ART) restorations, on a longitudinal basis, in the primary molars of children; and compare the success rate of ART restorations placed in school environment and in hospital dental setup.Study design: One dentist placed 120 ART restorations in 60 five- to seven year-olds who had bilateral matched pairs of carious primary molars. A split-mouth design was used to place restorations in school and in hospital dental setup, which were assigned randomly to contralateral sides. Restorations were evaluated after 6 and 12 months using the ART criteria. Results: The survival ra…
Il danno psichico da Disturbo Post-Traumatico da Stress (DPTS): aspetti clinici e testologici
2002
Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
2021
AbstractMaintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmacokinetics characteristics. Current evidence shows that ketamine does not increase and may instead decrease intracranial pressure, and its safety profile makes it a reliable tool in the prehospital environment. In this point of view, we discuss different aspects of the use of ketamine in the acute phase of TBI, with its potential benefits and pitfalls.
Corrigendum to “Neuromuscular electrophysiological disorders and muscle atrophy in mechanically-ventilated traumatic brain injury patients: New insig…
2019
Lactate and glucose as energy substrates and their role in traumatic brain injury and therapy
2009
Traumatic brain injury is a leading cause of disability and mortality worldwide, but no new pharmacological treatments are clinically available. A key pathophysiological development in the understanding of traumatic brain injury is the energy crisis derived from decreased cerebral blood flow, increased energy demand and mitochondrial dysfunction. Although still controversial, new findings suggest that brain cells try to cope in these conditions by metabolizing lactate as an energy substrate ‘on-demand’ in lieu of glucose. Experimental and clinical data suggest that lactate, at least when exogenously administered, is transported from astrocytes to neurons for neuronal utilization, essential…
Evaluating the citywide Edinburgh 20mph speed limit intervention effects on traffic speed and volume: A pre-post observational evaluation.
2021
Objectives Traffic speed is important to public health as it is a major contributory factor to collision risk and casualty severity. 20mph (32km/h) speed limit interventions are an increasingly common approach to address this transport and health challenge, but a more developed evidence base is needed to understand their effects. This study describes the changes in traffic speed and traffic volume in the City of Edinburgh, pre- and 12 months post-implementation of phased city-wide 20mph speed limits from 2016–2018. Methods The City of Edinburgh Council collected speed and volume data across one full week (24 hours a day) pre- and post-20mph speed limits for 66 streets. The pre- and post-sp…
Sensitive nerve function measurement in facial trauma : an observational study
2020
Background Facial trauma is responsible for various types of health damage and may be functional or aesthetic. Depending on the degree of energy released in this type of trauma, sometimes an irreversibility degree is obtained. This study aimed to perform an objective evaluation of traumatic peripheral nerve injuries resulting from mandibular fractures and midface, using silicon monofilaments. Material and Methods This was an observational, cross-sectional study. All patients with maxillofacial fractures, who were hospitalized by the department of Oral and Maxillofacial Surgery of Instituto Dr. José Frota Hospital, were randomly recruited and screened for inclusion in the present study. Sixt…