0000000000001935

AUTHOR

Matthias Menzel

showing 2 related works from this author

Compared Binding Properties between Resveratrol and Other Polyphenols to Plasmatic Albumin: Consequences for the Health Protecting Effect of Dietary …

2014

International audience; Phytophenols are considered to have beneficial effects towards human physiology. They are food microcomponents with potent chemopreventive properties towards the most three frequent contemporary human diseases, e.g., cardiovascular alterations, cancer and neurodegenerative pathologies. Related to this, the plasmatic form and plasmatic level of plant polyphenols in the body circulation are crucial for their efficiency. Thus, determinations of the binding process of resveratrol and of common flavonoids produced by major edible plants, berries and fruits to plasma proteins are essential. The interactions between resveratrol and albumin, a major plasma protein, were comp…

structural changes[SDV]Life Sciences [q-bio]Pharmaceutical ScienceReviewResveratrolresveratrol01 natural sciencesAnalytical Chemistryquercetinchemistry.chemical_compound[ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM]Resveratrol bindingDrug DiscoveryStilbenesBovine serum albuminComputingMilieux_MISCELLANEOUS0303 health sciencesbiologyfood and beveragesBlood proteins[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM]3. Good healthBiochemistryChemistry (miscellaneous)HealthMolecular MedicinefluorescencePlants EdibleQuercetinSerum albuminlcsh:QD241-44103 medical and health scienceslcsh:Organic chemistryHumans[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM]Physical and Theoretical ChemistryBinding siteSerum Albumin030304 developmental biologyFlavonoidsBinding Sites010405 organic chemistryOrganic ChemistryAlbuminPolyphenols0104 chemical sciencesDietchemistryFoodbiology.proteinaffinityMolecules
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Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake

2004

Resveratrol produced by several plants, berries and fruits, including grapes, is one of the best known natural food microcomponents with potent chemopreventive properties towards the most severe contemporary human diseases: cardiovascular sickness, cancer and neurodegenerative pathologies. Demonstration of its mechanism of action also implies the elucidation of the steps of bioavailability and bioabsorption in cells and tissues. In order to estimate the relationships between the amounts of resveratrol taken up by food or drink intake, and the several possible benefits illustrated from in vitro/in vivo experiments and from epidemiological studies, it is essential to demonstrate step by step …

CellPlasma protein bindingPharmacologyResveratrolBiologyBiochemistrychemistry.chemical_compoundIn vivoStilbenesTumor Cells CulturedmedicineAnimalsAnticarcinogenic AgentsHumansAnticarcinogenSerum AlbuminPharmacologyFatty Acidsfood and beveragesBiological TransportBlood ProteinsIn vitromedicine.anatomical_structureBiochemistryMechanism of actionchemistryResveratrolmedicine.symptomIntracellularProtein BindingBiochemical Pharmacology
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