0000000000002670

AUTHOR

César Fernández-de-las-peñas

0000-0003-3772-9690

showing 17 related works from this author

Localization of Muscle Edema and Changes on Muscle Contractility After Dry Needling of Latent Trigger Points in the Gastrocnemius Muscle.

2019

Background Myofascial trigger points (TrPs) are hyperirritable spots within taut bands of skeletal muscles that elicit local and referred pain when stimulated. Among the variety of techniques used for treating TrPs, dry needling (DN) is the most commonly applied intervention. The physiological mechanisms underlying the effects of DN remain to be elucidated. Objective To examine changes in skeletal muscle after DN in the area where the TrP is located. Methods We measured in vivo changes that occur in human skeletal muscle one hour after DN over a TrP with magnetic resonance imaging (MRI) and tensiomyography. The study included 18 asymptomatic subjects with a latent TrP in one medial gastrocn…

AdultMalemedicine.medical_specialtyTensiomyographyContractility03 medical and health sciencesGastrocnemius muscleYoung Adult0302 clinical medicineEdemaInternal medicinemedicineEdemaHumansMuscle SkeletalDry needlingmedicine.diagnostic_testbusiness.industrySkeletal muscleTrigger PointsMagnetic resonance imaging030229 sport sciencesGeneral MedicineMuscle stiffnessMagnetic Resonance ImagingAnesthesiology and Pain Medicinemedicine.anatomical_structureEndocrinologyDry NeedlingNeurology (clinical)medicine.symptombusiness030217 neurology & neurosurgeryMuscle ContractionPain medicine (Malden, Mass.)
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Mathematical Modeling for Neuropathic Pain: Bayesian Linear Regression and Self-Organizing Maps Applied to Carpal Tunnel Syndrome

2020

A better understanding of the connection between risk factors associated with pain and function may assist therapists in optimizing therapeutic programs. This study applied mathematical modeling to analyze the relationship of psychological, psychophysical, and motor variables with pain, function, and symptom severity using Bayesian linear regressions (BLR) and self-organizing maps (SOMs) in carpal tunnel syndrome (CTS). The novelty of this work was a transfer of the symmetry mathematical background to a neuropathic pain condition, whose symptoms can be either unilateral or bilateral. Duration of symptoms, pain intensity, function, symptom severity, depressive levels, pinch tip grip force, a…

medicine.medical_specialtyPhysics and Astronomy (miscellaneous)General Mathematicscarpal tunnel syndromeself-organizing maps03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationLinear regressionComputer Science (miscellaneous)MedicineCarpal tunnel030212 general & internal medicineCarpal tunnel syndromeRadial nervebusiness.industrylcsh:Mathematicsmathematical modelingmedicine.diseaselcsh:QA1-939Median nerveIntensity (physics)medicine.anatomical_structurePsicologiaEstadística bayesianaChemistry (miscellaneous)Neuropathic painbusinessBayesian linear regressionBayesian linear regression030217 neurology & neurosurgerySymmetry
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Spectral Clustering Reveals Different Profiles of Central Sensitization in Women with Carpal Tunnel Syndrome

2021

Identification of subgroups of patients with chronic pain provides meaningful insights into the characteristics of a specific population, helping to identify individuals at risk of chronification and to determine appropriate therapeutic strategies. This paper proposes the use of spectral clustering (SC) to distinguish subgroups (clusters) of individuals with carpal tunnel syndrome (CTS), making use of the obtained patient profiling to argue about potential management implications. SC is a powerful algorithm that builds a similarity graph among the data points (the patients), and tries to find the subsets of points that are strongly connected among themselves, but weakly connected to others.…

medicine.medical_specialtyCentral sensitizationPhysics and Astronomy (miscellaneous)General Mathematicscarpal tunnel syndromegroupssensitization03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationComputer Science (miscellaneous)QA1-939MedicineCarpal tunnelpain030212 general & internal medicineLead (electronics)Carpal tunnel syndromespectral clusteringbusiness.industryChronic painDones Malaltiesmedicine.diseaseSpectral clusteringIntensity (physics)medicine.anatomical_structureChemistry (miscellaneous)Hyperalgesiamedicine.symptombusiness030217 neurology & neurosurgeryMathematics
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Direct and Indirect Effects of Function in Associated Variables Such as Depression and Severity on Pain Intensity in Women with Carpal Tunnel Syndrome

2015

Objective To determine the direct and indirect effects of function on clinical variables such as age, pain intensity, years of the disease, severity of symptoms, and depression in women with electrodiagnostic and clinical diagnosis of carpal tunnel syndrome (CTS). Design A cross-sectional study. Setting Patients from an urban hospital referred to a university clinic. Methods Two hundred and forty-four (n = 224) women with CTS were included. Demographic and clinical data, duration of symptoms, function, symptom's severity of the symptoms, pain intensity, and depression were self-reported collected. Correlation and path analysis with maximum likelihood estimation were conducted to assess the …

Adultmedicine.medical_specialtyClinical variablesMaximum likelihoodPainDiseaseComorbiditySensitivity and SpecificitySeverity of Illness IndexRisk FactorsPrevalenceMedicineHumansCarpal tunnel syndromeAgedPain MeasurementHand functionbusiness.industryDepressionDirect effectsReproducibility of ResultsGeneral MedicineRecovery of FunctionMiddle Agedmedicine.diseaseCarpal Tunnel SyndromeCausalityAnesthesiology and Pain MedicineCross-Sectional StudiesPsicobiologiaSpainClinical diagnosisPhysical therapyNeuralgiaWomen's HealthFemaleNeurology (clinical)Self ReportSymptom AssessmentbusinessUrban hospital
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Sleep disturbances in tension-type headache and migraine

2017

Current research into the pathogenesis of tension-type headache (TTH) and migraine is focused on altered nociceptive pain processing. Among the potential factors that influence sensitization mechanisms, emotional stress, depression, or sleep disorders all have an essential role: they increase the excitability of nociceptive firing and trigger hyperalgesic responses. Sleep disturbances and headache disorders share common brain structures and pathogenic mechanisms and TTH, migraine, and sleep disturbances often occur together; for example, 50% of individuals who have either TTH or migraine have insomnia. Moreover, insomnia and poor sleep quality have been associated with a higher frequency an…

medicine.medical_specialtyInsomniaReviewAffect (psychology)lcsh:RC346-42903 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationmedicineInsomnia030212 general & internal medicinelcsh:Neurology. Diseases of the nervous systemDepression (differential diagnoses)MigrainePharmacologySleep qualitybusiness.industryTension-Type HeadacheHeadachemedicine.diseaseSleep in non-human animalsPoor sleepNeurologyMigraineNeurology (clinical)Headachesmedicine.symptombusinessSleep030217 neurology & neurosurgery
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Patient Profiling Based on Spectral Clustering for an Enhanced Classification of Patients with Tension-Type Headache

2020

Profiling groups of patients in clusters can provide meaningful insights into the features of the population, thus helping to identify people at risk of chronification and the development of specific therapeutic strategies. Our aim was to determine if spectral clustering is able to distinguish subgroups (clusters) of tension-type headache (TTH) patients, identify the profile of each group, and argue about potential different therapeutic interventions. A total of 208 patients (n = 208) with TTH participated. Headache intensity, frequency, and duration were collected with a 4-week diary. Anxiety and depressive levels, headache-related burden, sleep quality, health-related quality of life, pre…

medicine.medical_specialtyPressure painPopulationgroupslcsh:Technologysensitizationlcsh:Chemistry03 medical and health sciences0302 clinical medicineQuality of lifePatient profilingInternal medicinemedicineGeneral Materials SciencepaineducationInstrumentationlcsh:QH301-705.5030304 developmental biologyFluid Flow and Transfer Processes0303 health scienceseducation.field_of_studyspectral clusteringSleep qualitybusiness.industrylcsh:TProcess Chemistry and TechnologyGeneral Engineeringtension-type headacheSpectral clusteringlcsh:QC1-999Computer Science ApplicationsPsicologialcsh:Biology (General)lcsh:QD1-999lcsh:TA1-2040Anxietymedicine.symptombusinesslcsh:Engineering (General). Civil engineering (General)030217 neurology & neurosurgerylcsh:PhysicsApplied Sciences
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Is the association between health-related quality of life and fatigue mediated by depression in patients with multiple sclerosis? A Spanish cross-sec…

2018

OBJECTIVES: To determine the mediating effects of depression on health-related quality of life and fatigue in individuals with multiple sclerosis (MS). DESIGN: A cross-sectional study. SETTING: Tertiary urban hospital. PARTICIPANTS: One hundred and eight patients (54% women) with MS participated in this study. OUTCOME MEASURES: Demographic and clinical data (weight, height, medication and neurological impairment), fatigue (Fatigue Impact Scale), depression (Beck Depression Inventory-II) and health-related quality of life (Short-Form Health Survey 36) were collected. RESULTS: Fatigue was significantly associated with bodily pain, physical function, mental health and depression. Depression wa…

AdultMaleMultiple SclerosisCross-sectional studyPainPhysical functionTertiary Care Centers03 medical and health sciences0302 clinical medicinemedicineHumansIn patient030212 general & internal medicineLongitudinal Studies1506FatigueHealth related quality of lifePsychiatric Status Rating Scalesbusiness.industryDepressionMultiple sclerosisResearchGeneral MedicineMiddle Agedmedicine.diseaseMental healthBodily painCross-Sectional StudiesMental HealthNeurologyquality of lifeSpainQuality of LifeRegression Analysis1713Femalefatiguebusiness030217 neurology & neurosurgeryClinical psychologyUrban hospitalBMJ open
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Myogenic temporomandibular disorders: Clinical systemic comorbidities in a female population sample

2016

Background Myogenic temporomandibular disorders (MTMD) frequently coexist with other clinical conditions in the same individual. In the last decades, several authors have analyzed these comorbidities looking for the origin of this overlapping. Objetives The aim of this study was to perform a comparative anaylisis between a group of patients with MTMD and a control group of dental patients without dysfunctional pathology to assess whether there are significant differences in the presence of systemic medical comorbidities between the two groups. Material and Methods Restrospective epidemiological analysis, based on medical questionnaires in a group of 31 patients, women, aged from 24 to 58 (a…

Adultmedicine.medical_specialtyPainDysfunctional familyComorbidityYoung Adult03 medical and health sciences0302 clinical medicineFacial PainSurveys and QuestionnairesInternal medicineEpidemiologymedicineHumansYoung adultGeneral DentistryPathologicalbusiness.industryResearchHeadache030206 dentistryMiddle AgedTemporomandibular Joint Disorders:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseComorbidityOrofacial Pain-TMJDOtorhinolaryngologyJoint painUNESCO::CIENCIAS MÉDICASPhysical therapyFemaleSurgerymedicine.symptomHeadachesbusiness030217 neurology & neurosurgeryTinnitusMedicina Oral Patología Oral y Cirugia Bucal
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Gender differences in variables associated with sleep quality in chronic tension type headache

2018

We aimed to evaluate gender differences in the relationships between headache features, sleep quality, anxiety, depressive symptoms, and burden of headache in 193 patients (73 percent women) with chronic tension type headache (CTTH). Sleep quality was assessed with the Pittsburgh Sleep Quality Index. Headache features were collected with a four-week diary. The Hospital Anxiety and Depression Scale was used to assess anxiety/depressive symptoms. Headache Disability Inventory was used to evaluate the burden of headache. In men with CTTH, sleep quality was positive correlated with headache frequency (r = 0.310; p = .018), emotional (r = 0.518; p < .001) and physical (r = 0.468; p < .001) burde…

AdultMalePain ThresholdSleep Wake Disordersmedicine.medical_specialtyChronic tension-type headachePainTension Type HeadacheAnxietyHospital Anxiety and Depression ScalePittsburgh Sleep Quality Index03 medical and health sciencesSex Factors0302 clinical medicinemedicineHumans030212 general & internal medicineDepressive symptomsSleep qualityDepressionbusiness.industryTension-Type HeadacheGenderGeneral MedicineMiddle AgedStepwise regressionDepressive SymptomsPoor sleepSleep QualityQuality of LifePhysical therapySleep DeprivationAnxietyFemalemedicine.symptomSleepbusiness030217 neurology & neurosurgeryWomen &amp; Health
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Effects of Adding Motor Imagery to Early Physical Therapy in Patients with Knee Osteoarthritis who Had Received Total Knee Arthroplasty

2020

Abstract Objective To investigate the effects of the inclusion of motor imagery (MI) principles into early physical therapy on pain, disability, pressure pain thresholds (PPTs), and range of motion in the early postsurgical phase after total knee arthroplasty (TKA). Methods A randomized clinical trial including patients with knee osteoarthritis who have received TKA was conducted. Participants were randomized to receive five treatment sessions of either physical therapy with or without MI principles in an early postsurgical phase after a TKA (five days after surgery). Pain intensity (visual analog scale [VAS], 0–100), pain-related disability (short-form Western Ontario McMaster Universities…

medicine.medical_specialtyWOMACVisual analogue scaleTotal knee arthroplastyOsteoarthritislaw.invention03 medical and health sciences0302 clinical medicineMotor imageryRandomized controlled triallawThreshold of painmedicineHumans030212 general & internal medicineRange of Motion ArticularArthroplasty Replacement KneePhysical Therapy ModalitiesOntariobusiness.industryGeneral MedicineOsteoarthritis Kneemedicine.diseaseTreatment OutcomeAnesthesiology and Pain MedicinePhysical therapyNeurology (clinical)Range of motionbusiness030217 neurology & neurosurgery
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The number of symptoms at the acute COVID-19 phase is associated with anxiety and depressive long-term post-COVID symptoms: A multicenter study

2021

2019-20 coronavirus outbreakmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)SARS-CoV-2business.industrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)COVID-19AnxietyAnxiety DisordersTerm (time)Psychiatry and Mental healthClinical PsychologyMulticenter studyInternal medicineHumansMedicineAnxietymedicine.symptombusinessLetter to the EditorJournal of Psychosomatic Research
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Differences in Long-COVID Symptoms between Vaccinated and Non-Vaccinated (BNT162b2 Vaccine) Hospitalized COVID-19 Survivors Infected with the Delta V…

2022

This study compared differences in the presence of post-COVID symptoms among vaccinated and non-vaccinated COVID-19 survivors requiring hospitalization due to the Delta (B.1.617.2) variant. This cohort study included hospitalized subjects who had survived SARS-CoV-2 infection (Delta variant) from July to August 2021 in an urban hospital in Madrid, Spain. Individuals were classified as vaccinated if they received full administration (i.e., two doses) of BNT162b2 (“Pfizer-BioNTech”) vaccines. Other vaccines were excluded. Those with just one dose of the BNT162b2 vaccine were considered as non-vaccinated. Patients were scheduled for a telephone interview at a follow-up around six months after …

PharmacologyInfectious DiseasesDrug DiscoveryImmunologyCOVID-19; vaccine; post-COVID; Delta; hospitalizationPharmacology (medical)Vaccines
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Subgrouping factors influencing migraine intensity in women: A semi-automatic methodology based on machine learning and information geometry

2019

[EN] Background Migraine is a heterogeneous condition with multiple clinical manifestations. Machine learning algorithms permit the identification of population groups, providing analytical advantages over other modeling techniques. Objective The aim of this study was to analyze critical features that permit the differentiation of subgroups of patients with migraine according to the intensity and frequency of attacks by using machine learning algorithms. Methods Sixty-seven women with migraine participated. Clinical features of migraine, related disability (Migraine Disability Assessment Scale), anxiety/depressive levels (Hospital Anxiety and Depression Scale), anxiety state/trait levels (S…

AdultMigraine DisordersMachine learningcomputer.software_genreMachine LearningDisability Evaluation03 medical and health sciences0302 clinical medicine030202 anesthesiologyMachine learningHumansMedicine03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edadesInformation geometryPhysical ExaminationMigraineMultisource variabilityThesaurus (information retrieval)business.industryMiddle Agedmedicine.diseaseAnesthesiology and Pain MedicineMigraineFISICA APLICADAFemaleArtificial intelligenceSemi automaticbusinessMATEMATICA APLICADAcomputer030217 neurology & neurosurgeryRandom forest
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Post-COVID functional limitations on daily living activities are associated with symptoms experienced at the acute phase of SARS-CoV-2 infection and …

2022

Microbiology (medical)medicine.medical_specialty2019-20 coronavirus outbreakInfectious DiseasesActivities of daily livingMulticenter studyCoronavirus disease 2019 (COVID-19)business.industrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Emergency medicinemedicinebusinessUnit (housing)Journal of Infection
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Identification of Subgroups of Women with Carpal Tunnel Syndrome with Central Sensitization.

2016

Identification of subjects with different sensitization mechanisms can help to identify better therapeutic strategies for carpal tunnel syndrome (CTS). The aim of the current study was to identify subgroups of women with CTS with different levels of sensitization.A total of 223 women with CTS were recruited. Self-reported variables included pain intensity, function, disability, and depression. Pressure pain thresholds (PPT) were assessed bilaterally over median, ulnar, and radial nerves, C5-C6 joint, carpal tunnel, and tibialis anterior to assess widespread pressure pain hyperalgesia. Heat (HPT) and cold (CPT) pain thresholds were also bilaterally assessed over the carpal tunnel and the the…

AdultPain Thresholdmedicine.medical_specialtySubgroup analysisClinical prediction ruleThumb03 medical and health sciences0302 clinical medicineThreshold of painmedicineHumansCarpal tunnel030212 general & internal medicineCarpal tunnel syndromePain MeasurementCentral Nervous System Sensitizationbusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseCarpal Tunnel Syndromenervous system diseasesAnesthesiology and Pain Medicinemedicine.anatomical_structureAnesthesiaHyperalgesiaPhysical therapyFemaleNeurology (clinical)medicine.symptombusiness030217 neurology & neurosurgeryThenar eminencePain medicine (Malden, Mass.)
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Electromyographic Activity Evolution of Local Twitch Responses During Dry Needling of Latent Trigger Points in the Gastrocnemius Muscle: A Cross-Sect…

2019

Abstract Objective Trigger points (TrPs) are hypersensitive spots within taut bands of skeletal muscles that elicit referred pain and motor changes. Among the variety of techniques used for treating TrPs, dry needling is one of the most commonly applied interventions. The question of eliciting local twitch responses (LTRs) during TrP dry needling is unclear. Our main aim was to investigate the evolution of the electromyographic (EMG) peak activity of each LTR elicited during dry needling into latent TrPs of the gastrocnemius medialis muscle. Methods Twenty asymptomatic subjects with latent TrPs in the gastrocnemius medialis muscle participated in this cross-sectional study. Changes in EMG s…

medicine.medical_specialtyElectromyographyAsymptomatic03 medical and health sciencesGastrocnemius muscle0302 clinical medicineInternal medicinemedicineHumansMuscle SkeletalMyofascial Pain Syndromes030222 orthopedicsDry needlingReferred painmedicine.diagnostic_testbusiness.industryTrigger PointsGeneral MedicineConfidence intervalData at RestCross-Sectional StudiesAnesthesiology and Pain MedicineDry NeedlingCardiologyNeurology (clinical)Analysis of variancemedicine.symptombusiness030217 neurology & neurosurgeryPain Medicine
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Data from: Is the association between health-related quality of life and fatigue mediated by depression in patients with multiple sclerosis? A Spanis…

2017

Objectives: To determine the mediating effects of depression on health-related quality of life and fatigue in individuals with multiple sclerosis (MS). Design: A cross-sectional study. Setting: Tertiary urban hospital. Participants: One hundred and eight patients (54% women) with MS participated in this study. Outcome measures: Demographic and clinical data (weight, height, medication, and neurological impairment), fatigue (Fatigue Impact Scale-FIS), depression (Beck Depression Inventory-BDI/II) and health-related quality of life (Short-Form Health Survey 36 - SF36) were collected. Results: Fatigue was significantly associated with bodily pain, physical function, mental health and depressio…

medicine and health careQuality of lifeMultiple SclerosisDepressionMedicinefatigueLife sciences
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