0000000000004630
AUTHOR
Vasto Sonya
Bioimpedance: a new approach for studying longevity
Centenarians are the best model to study successful ageing. Unfortunately, they are rare and do not have an aged-matched control population to compare their exceptional characteristics with non-longevous people. Considering the complexity of molecular studies, the opportunity to analyse the centenarian phenotype with anthropometry could be an easy and no invasive interesting solution to identify peculiar measurable variables. In addition to the classic measurements, the bioelectrical impedance could be considered. This method permits to analyse the body composition, in terms of fat free mass and fat mass. Ageing is related to reduced fat free mass and increased body fat. The reduction of th…
Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders
In recent years, there has been a growing interest, supported by a large number of experimental and epidemi-ological studies, for the beneficial effects of some phenolic substances, contained in commonly used spices and herbs, in preventing various age-related pathologic conditions, ranging from cancer to neurodegenerative diseases. Although the exact mechanisms by which polyphenols promote these effects remain to be elucidated, several reports have shown their ability to stimulate a general xenobiotic response in the target cells, activating multiple defense genes. Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces…