0000000000004896
AUTHOR
Alvaro Castilla
Enantioselective zinc-mediated conjugate alkynylation of saccharin-derived 1-aza-butadienes
The enantioselective 1,4-alkynylation of conjugated imines derived from saccharin with aryl- and alkyl-substituted terminal alkynes has been achieved. The reaction mediated by diethylzinc in the presence of a catalytic amount of a bis(hydroxy)malonamide chiral ligand provides the corresponding imines bearing a propargylic stereocenter with moderate yields and fair to excellent enantioselectivities.
Enantioselective addition of sodium bisulfite to nitroalkenes. A convenient approach to chiral sulfonic acids
An enantioselective organocatalytic addition of sodium bisulfite to (E)-nitroalkenes has been developed by using a chiral bifunctional organocatalyst. The present methodology provides a variety of chiral β-nitroethanesulfonic acid compounds (17 examples) with excellent results: up to 99% yield and excellent enantioselectivity (up to 96% ee). The reaction tolerates (hetero)aryl and alkyl substituents on the β-nitroalkenes, and β,β-disubstituted nitroalkenes.
CCDC 2098671: Experimental Crystal Structure Determination
Related Article: Ehsan Sheikhi, Narjes Rezaei, Alvaro Castilla, Amparo Sanz���Marco, Carlos Vila, M. Carmen Mu��oz, Jos�� R. Pedro, Gonzalo Blay|2021|Eur.J.Org.Chem.|2021|5284|doi:10.1002/ejoc.202101064
CCDC 1992564: Experimental Crystal Structure Determination
Related Article: Gonzalo Blay, Alvaro Castilla, David Sanz, Amparo Sanz-Marco, Carlos Vila, M. Carmen Muñoz, José R. Pedro|2020|Chem.Commun.|56|9461|doi:10.1039/D0CC04221H