0000000000007458

AUTHOR

César Viseras-iborra

showing 2 related works from this author

Nanocarrier based on halloysite and fluorescent probe for intracellular delivery of peptide nucleic acids

2022

The development of systems able to deliver genetic material into a target site is a challenge for modern medicine. Single-stranded peptide nucleic acids have attracted attention as promising therapeutic molecules for diagnostic and gene therapy. However, their poor cell membrane permeability represents a drawback for biomedical applications. Halloysite nanotubes (HNTs) are emerging materials in drug delivery applications both for their ability to penetrate cell membranes and for enhancing the solubility of drugs in biological media. Herein, we report the first example of the use of a nanocarrier based on halloysite labelled with fluorescent switchable halochromic oxazine molecules, to deliv…

Peptide Nucleic AcidsNanotubesHalloysite nanotubesHalloysite nanotubes PNA Covalent modificationsSettore CHIM/06 - Chimica OrganicaHalochromic switchCovalent modificationsSettore CHIM/12 - Chimica Dell'Ambiente E Dei Beni CulturaliSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsBiomaterialsColloid and Surface ChemistryCell Line TumorCellular uptakeSettore BIO/14 - FarmacologiaClayPNAFluorescent Dyes
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Exploring the cellular uptake of hectorite clay mineral and its drug carrier capabilities.

2022

In the last years, the use of clay minerals for pharmaceutical purposes has increased due to their interesting properties. Hectorite (Ht) is a clay belonging to the smectite group which has attracted attention for applications in biology, tissue engineering and as drug carrier and delivery system. However, the mechanisms involved in Ht cellular uptake and transport into cells, are still unclear. Herein, we used a labeled Ht (Ht/1Cl) to study both the cellular uptake, by confocal laser scanning microscopy, and internalization pathways involved in the cellular uptake, by various endocytosis-inhibiting studies and fluorescence microscopy. These studies highlighted that Ht can penetrate the cel…

Drug CarriersCytotoxicitySilicatesSettore CHIM/06 - Chimica OrganicaSurfaces and InterfacesGeneral MedicineColloid and Surface ChemistryMethotrexateCellular internalizationCellular uptakeHectoriteSettore BIO/14 - FarmacologiaClayPhysical and Theoretical ChemistryBiotechnologyColloids and surfaces. B, Biointerfaces
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