0000000000008319
AUTHOR
Bellavia G
I LUOGHI DELLA CURA E DEL MORIRE: REPARTO DI GERIATRIA: TRE ANNI DI ATTIVITÀ
PREVENZIONE NELLE MALATTIE NEURODEGENERATIVE NELL’ANZIANO
ANEMIA E DECLINO FUNZIONALE NELL’ANZIANO
Calorimetric study of myoglobin embedded in trehalose-water matrixes
It has been suggested that in ‘dry’ protein–trehalose–water systems, water–mediated hydrogen bond network, whose strength increases by drying, anchors the protein to its surroundings. To further characterize this effect, we performed a DSC study on low-water myoglobin–trehalose systems. The denaturation temperature resulted to increase by decreasing hydration, and linearly correlated to the glass transition temperature of both the ternary protein–water–trehalose and the binary water–trehalose systems. Further measurements are being performed to investigate eventual differences among different saccharides.
RIABILITAZIONE NEUROMOTORIA NELLA M. DI PARKINSON: CONDIZIONAMENTO SENSORIALE
Protein Thermal Denaturation and Matrix Glass Transition in Different Protein−Trehalose−Water Systems
Biopreservation by saccharides is a widely studied issue due to its scientific and technological importance; in particular, ternary amorphous protein-saccharide-water systems are extensively exploited to model the characteristics of the in vivo biopreservation process. We present here a differential scanning calorimetry (DSC) study on amorphous trehalose-water systems with embedded different proteins (myoglobin, lysozyme, BSA, hemoglobin), which differ for charge, surface, and volume properties. In our study, the protein/trehalose molar ratio is kept constant at 1/40, while the water/sugar molar ratio is varied between 2 and 300; results are compared with those obtained for binary trehalose…
DEPRESSIONE, ANZIANI E PSICOTERAPIA
Elevated homocysteine is associated with lower handgrip strength in elderly subjects
PREVENZIONE DELLE MALATTIE NEURODEGENERATIVE NELL’ANZIANO
Adherence, compliance and persistence to oral antineoplastic therapy: a review focused on chemotherapeutic and biologic agents
Introduction: To date, orally administered chemotherapy and biologic agents represent a significant percentage of all antineoplastic treatments in several types of cancer, which are most likely to increase in the near future. In this scenario, the issue of adherence and persistence to oral therapy is a key issue since poor compliance to oral antineoplastic treatments may negatively influence patients' clinical outcomes and, in turn, cause an increase in costs, number of hospitalizations and time spent in the hospital. Areas covered: The issue of adherence to new oral chemotherapeutic and/or biologic agents has not been deeply evaluated and data published in medical literature are quite scar…
DOMOTICA, UTENZA DEBOLE E ANZIANI
DEPRESSIONE E AUTO PERCEZIONE DELLA SALUTE IN SOGGETTI ANZIANI ITALIANI: EUROPEAN STUDY ON ADULT WELL-BEING (ESAW)
CO-MORBILITA’ E DEPRESSIONE NELL’ANZIANO
ELEVATED HOMOCYSTEINE IS ASSOCIATED WITH LOWER HANDGRIP STRENGTH IN ELDERLY PERSONS
Multibody numerical simulation for vehicle – pedestrian crash test and analysis of characteristic parameters
COENZIMA Q E MALATTIA DI PARKINSON
Development of an anthropomorphic model for vehicle-pedestrian crash test
NECESSITÀ DI UNA PERIODICA ASSISTENZA GERIATRICA DOMICILIARE. DESCRIZIONE DI UN CASO CLINICO
UN NUOVO INDICE PROGNOSTICO-TERAPEUTICO IN ONCOLOGIA GERIATRICA
SINTOMI COGNITIVI E DEPRESSIVI IN SOGGETTI NON DEMENTI CON MALATTIA CEREBROVASCOLARE SOTTOCORTICALE
PARKINSON E DEMENZA : VALUTAZIONE COMPARATIVA TRA INDICI NEUROPSICOLOGICI E NEURORADIOLOGICI
HOSPICE E TERMINALITÀ IN PAZIENTI CON DEMENZA
TERAPIE DI RIABILITAZIONE COGNITIVA NEL COMPLESSO PARKINSON-DEMENZA NELL’ANZIANO. Caso clinico
Thermal denaturation of myoglobin in water--disaccharide matrixes: relation with the glass transition of the system.
Proteins embedded in glassy saccharide systems are protected against adverse environmental conditions [Crowe et al. Annu. Rev. Physiol. 1998, 60, 73-103]. To further characterize this process, we studied the relationship between the glass transition temperature of the protein-containing saccharide system (T(g)) and the temperature of thermal denaturation of the embedded protein (T(den)). To this end, we studied by differential scanning calorimetry the thermal denaturation of ferric myoglobin in water/disaccharide mixtures containing nonreducing (trehalose, sucrose) or reducing (maltose, lactose) disaccharides. All the samples studied are, at room temperature, liquid systems whose viscosity …