Prevalenza di infezione da patogeni a trasmissione ematica (HIV, HBV, HCV) in tossicodipendenti afferenti ai SERT dell’area palermitana

2004

Prevalenza di infezione da patogeni a trasmissione ematica (HIV,HBV,HCV)in tossicodipendenti afferenti ai SERT dell'area palermitana

2004

Background. Kaposi sarcoma (KS) is primarily caused by human herpesvirus (HHV)-8 infection, and the risk is increased with high HHV-8 lytic or latent antibody titers or the detection of HHV-8 DNA in peripheral blood mononuclear cells (PBMCs). Host genes important for control of HHV-8 infection are not well characterized. Methods. In 172 HHV-8 latent nuclear antigen (LANA)-seropositive adults in Italy without KS, we examined correlations of common variants in host immune genes with the detection of HHV-8 DNA in PBMCs and with high lytic and latent antibody titers. Twenty-eight single-nucleotide polymorphisms in 14 genes were analyzed. We detected HHV-8 DNA in PBMCs with real-time amplificati…