0000000000009773
AUTHOR
Roman Vuillaume
Identification of Synaptic Integration Mode in CA3 Pyramidal Neuron Model
International audience; A morphologically realistic and anisotropic model of CA3 pyramidal neuron was developed to determine the synaptic integration modes the neuron is able to perform. Linearity and nonlinearity were identified in different synaptic locations with varying active mechanisms such as the presence of ionic channels in the dendritic arbor and the types of receptors in the synapse. Quantification of synaptic integration was performed using paired-pulse stimulation protocol and subthreshold input/output (sI/O) transformation. Results show that the mode of synaptic integration is location-dependent while the linearity or nonlinearity in the integration is mainly influenced by the…
Computational analysis of a multi-varied biomimetic neural network
In recent years, astrocytes have emerged as such elements involved in inter-neuronal communication that they are increasingly considered in the synaptic coupling connecting neurons and synapses, thus constituting tripartite synapses. Many studies have focused on this astrocytic influence. With the description of the basic mechanisms of synapses, as well as the influence of gliotransmission, we emphasize that gliotransmission to extra-synaptic areas has so far been mainly studied in vivo and in vitro. We come closer to the paradigms used in AI, by proposing an analysis of the astrocyte influence on the variations of the parameters governing synaptic and extra-synaptic plasticity.We sought to…