Hypogonadism and Hormone Replacement Therapy on Bone Mass of Adult Women with Thalassemia Major

2002

We studied bone mass and metabolism in 30 adult women (age 28.5 +/- 1.3) with thalassemia major (TM) and evaluated whether prolonged hormone replacement therapy (HRT) was able to optimize bone accrual. TM patients had reduced bone mass, increased bone turnover and lower serum gonadotropin and estradiol levels compared with 10 normal women of similar age. A significant correlation was found between bone mass and sex hormone levels. Six TM patients with normal ovarian function had normal bone turnover markers and modestly low bone mass (lumbar spine -1.29 +/- 0.31; femoral neck -0.60+/-0.21; Z-score). The other 24 TM women were hypogonadic and had significantly lower bone mass for age (lumbar…

Calcium Metabolism in the Elderly

1998

Mineral homeostasis represents one of the multiple areas at risk in the elder population. This includes the ion calcium, which is the most abundant inorganic element in the human body and an essential key for many physiologic processes (1).

-Correlation between deficiency of 25 (OH) vitamin D and liver damage in adult talassemic subjects

2004

BRCA1 and BRCA2 variants of uncertain clinical significance and their implications for genetic counseling

2009

Alendronate 70 mg on patients affected with thalassemia major: An observational study

2005

BRCA1 and BRCA2 germline mutations in sicilian breast and/or ovarian cancer families and their association with familial profiles

2009

Correlation between deficienty of 25 (oh) vitamin D and liver damage in adult talassemic subjects

2004

Il polimorfismo C4887A del gene CYP1A1 influenza il metabolismo estrogenico e la massa ossea

2004