0000000000010371
AUTHOR
A. Ruíz
Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats
Oxidative stress is involved in the pathogenesis of pulmonary fibrosis, therefore antioxidants may be of therapeutic value. Clinical work indicates that N ‐acetylcysteine (NAC) may be beneficial in this disease. The activity of this antioxidant was examined on bleomycin-induced lung damage, mucus secretory cells hyperplasia and mucin Muc5ac gene expression in rats. NAC (3 mmol·kg−1·day−1) or saline was given orally to Sprague-Dawley rats for 1 week prior to a single intratracheal instillation of bleomycin (2.5 U·kg−1) and for 14 days postinstillation. NAC decreased collagen deposition in bleomycin-exposed rats (hydroxyproline content was 4,257±323 and 3,200±192 µg·lung−1 in vehicle- and NAC…
Comparative morphometric evaluation of microvessel density and nuclear area in ductal carcinoma in situ and hyperplastic ductal breast lesions
Abstract Tumour angiogenesis, as assayed by microvessel density, has been proposed as a prognostic factor in invasive breast cancer. Angiogenesis in noninvasive tumours and hyperplastic mammary lesion has not been well-established. The aim of the present study was to evaluate the microvessel density in ductal proliferative breast lesions and to investigate the relationships between microvessel density and histopathologic features. In addition, morphometric measurement of nuclear area in ductal proliferative breast lesions and its relationship with microvessel density has been examined. Thirty-four cases were evaluated, 19 ductal carcinomas in situ (DCIS) and 15 of usual and atypical ductal …
CCDC 1433632: Experimental Crystal Structure Determination
Related Article: G. Hernández, S. Bernès, O. Portillo, A. Ruíz, G.E. Moreno, R. Gutiérrez|2015|Acta Crystallogr.,Sect.E:Cryst.Commun.|71|1462|doi:10.1107/S2056989015020368
CCDC 1433631: Experimental Crystal Structure Determination
Related Article: G. Hernández, S. Bernès, O. Portillo, A. Ruíz, G.E. Moreno, R. Gutiérrez|2015|Acta Crystallogr.,Sect.E:Cryst.Commun.|71|1462|doi:10.1107/S2056989015020368
CCDC 1433633: Experimental Crystal Structure Determination
Related Article: G. Hernández, S. Bernès, O. Portillo, A. Ruíz, G.E. Moreno, R. Gutiérrez|2015|Acta Crystallogr.,Sect.E:Cryst.Commun.|71|1462|doi:10.1107/S2056989015020368