An adaptive multimeme algorithm for designing HIV multidrug therapies.
This paper proposes a period representation for modeling the multidrug HIV therapies and an Adaptive Multimeme Algorithm (AMmA) for designing the optimal therapy. The period representation offers benefits in terms of flexibility and reduction in dimensionality compared to the binary representation. The AMmA is a memetic algorithm which employs a list of three local searchers adaptively activated by an evolutionary framework. These local searchers, having different features according to the exploration logic and the pivot rule, have the role of exploring the decision space from different and complementary perspectives and, thus, assisting the standard evolutionary operators in the optimizati…
An adaptive prudent-daring evolutionary algorithm for noise handling in on-line PMSM drive design
This paper studies the problem of the optimal control design of permanent magnet synchronous motor (PMSM) drives taking into account the noise due to sensors and measurement devices. The problem is analyzed by means of an experimental approach which considers noisy data returned by the real plant (on-line). In other words, each fitness evaluation does not come from a computer but from a real laboratory experiment. In order to perform the optimization notwithstanding presence of the noise, this paper proposes an Adaptive Prudent- Daring Evolutionary Algorithm (APDEA). The APDEA is an evolutionary algorithm with a dynamic parameter setting. Furthermore, the APDEA employs a dynamic penalty ter…