0000000000016650

AUTHOR

Andrew J. Demello

showing 2 related works from this author

Growing and Shaping Metal–Organic Framework Single Crystals at the Millimeter Scale

2020

Controlling and understanding the mechanisms that harness crystallization processes is of utmost importance in contemporary materials science and, in particular, in the realm of reticular solids where it still remains a great challenge. In this work, we show that environments mimicking microgravity conditions can harness the size and shape of functional biogenic crystals such as peptide-based metal–organic frameworks (MOFs). In particular, we demonstrate formation of the largest single crystals with controlled nonequilibrium shapes of peptide-based MOFs reported to date (e.g., those featuring curved crystal habits), as opposed to the typical polyhedral microcrystals obtained under bul…

ChemistryScale (chemistry)Crystal growthNanotechnologyGeneral Chemistry010402 general chemistry01 natural sciencesBiochemistryCatalysis0104 chemical scienceslaw.inventionColloid and Surface ChemistrySimulated microgravitylawMetal-organic frameworkCrystallizationCrystal habitBiomineralizationJournal of the American Chemical Society
researchProduct

Biodegradable Metal-Organic Framework-Based Microrobots (MOFBOTs).

2020

Microrobots and metal–organic frameworks (MOFs) have been identified as promising carriers for drug delivery applications. While clinical applications of microrobots are limited by their low drug loading efficiencies and the poor degradability of the materials used for their fabrication, MOFs lack motility and targeted drug delivery capabilities. The combination of these two fields marks the beginning of a new era; MOF‐based small‐scale robots (MOFBOTs) for biomedical applications. Yet, biodegradability is a major hurdle in the field of micro‐ and nanoswimmers including small‐scale robots. Here, a highly integrated MOFBOT that is able to realize magnetic locomotion, drug delivery, and selec…

zeolitic imidazolate frameworksMaterials scienceBiomedical EngineeringPharmaceutical ScienceNanotechnology02 engineering and technology010402 general chemistrybiodegradation01 natural sciencesBiomaterialsmetal–organic frameworksDrug Delivery SystemsNeoplasmsHumansMetal-Organic FrameworksBiodegradable metal021001 nanoscience & nanotechnologyControlled release0104 chemical sciencesMagnetic FieldsTargeted drug deliverySelective degradationDoxorubicindrug deliveryDrug deliverybiodegradation; drug delivery; metal–organic frameworks; microrobots; zeolitic imidazolate frameworksChemotherapeutic drugs0210 nano-technologymicrorobotsAdvanced healthcare materials
researchProduct