0000000000017131

AUTHOR

Alejandro Alemán

showing 4 related works from this author

Machine Learning-Based Approach Highlights the Use of a Genomic Variant Profile for Precision Medicine in Ovarian Failure

2021

Ovarian failure (OF) is a common cause of infertility usually diagnosed as idiopathic, with genetic causes accounting for 10–25% of cases. Whole-exome sequencing (WES) may enable identifying contributing genes and variant profiles to stratify the population into subtypes of OF. This study sought to identify a blood-based gene variant profile using accumulation of rare variants to promote precision medicine in fertility preservation programs. A case–control (n = 118, n = 32, respectively) WES study was performed in which only non-synonymous rare variants &lt

0301 basic medicineInfertilityOncologygenomic taxonomymedicine.medical_specialtyprecision medicineovarian failurePopulationMedicine (miscellaneous)BiologyGenoma humàArticlewhole exome sequencing03 medical and health sciences0302 clinical medicineInternal medicinemedicinesingle nucleotide variantFertility preservationeducationGeneExome sequencingeducation.field_of_study030219 obstetrics & reproductive medicinebusiness.industryRpersonalized medicinePrecision medicinemedicine.diseaseprediction modelMinor allele frequency030104 developmental biologyGinecologiaMedicineovaryPersonalized medicineinfertilitybusinessgenome variant profileJournal of Personalized Medicine
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P–294 Mapping COVID–19 affected genes from blood in a Window of implantation co-expression network reveals a potentially compromised landscape

2021

Abstract Study question Could the transcriptomic and functional landscape of the window of implantation be compromised by SARS-COV–2 infection? Summary answer Some of the main genes and pathways involved in the window of implantation are affected in blood of COVID–19 patients and receptivity could be affected. What is known already There is a concern whether SARS-COV–2 can disrupt assisted reproduction treatments (ARTs) and fertility in short and long terms. In the endometrium, it was found that genes related to the viral infection (ACE2, TMPRSS2/4, CTSL/B) are involved in menstrual cycle progression, especially in the Window of Implantation (WOI). However, there are no studies describing t…

Poster Viewing2019-20 coronavirus outbreakReproductive MedicineCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)RehabilitationObstetrics and GynecologyWindow (computing)BiologyGeneAcademicSubjects/MED00905Cell biologyEndometriosis Endometrium and Fallopian Tube and Benign Disorders of the Endometrium and Fallopian TubeHuman Reproduction (Oxford, England)
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Uterine disorders affecting female fertility: what are the molecular functions altered in endometrium?

2020

[EN]: Objective:To determine the molecular functions of genes exhibiting altered expression in the endometrium of women with uterine disorders affecting fertility. Design: Retrospective analysis integrating case and control data from multiple cohorts with endometrium gene expression in women with uterine disorders. Setting: Infertility research department affiliated with a university hospital. Patient(s): Two hundred and forty women, 121 of whom were controls, 119 of whom had endometrial adenocarcinoma (ADC), recurrent implantation failure (RIF), recurrent pregnancy loss (RPL), or stage II–IV endometriosis. Intervention(s): None. Main Outcome Measure(s): Genomewide gene expression and alter…

0301 basic medicineInfertilityAbortion Habitualendometrial receptivitymedia_common.quotation_subjectEndometriosisEndometriosisPhysiologyFertilityProtein degradationAdenocarcinomaEndometrium03 medical and health sciencesEndometrium0302 clinical medicineRisk FactorsDatabases GeneticmedicineHumansEmbryo Implantationmedia_commonRetrospective StudiesUterine DiseasesPregnancy030219 obstetrics & reproductive medicineEmbryo implantation alterations endometrial factor endometrial receptivity endometrial transcriptomics functional genomic meta-analysisbusiness.industryurogenital systemObstetrics and GynecologyCell cyclemedicine.diseaseendometrial factorUterine DisorderEndometrial Neoplasmsendometrial transcriptomics030104 developmental biologymedicine.anatomical_structureFertilityReproductive MedicineGene Expression RegulationEmbryo implantation alterationsfunctional genomic meta-analysisFemalebusinessInfertility FemaleGenome-Wide Association Study
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Transcriptional changes through menstrual cycle reveal a global transcriptional derepression underlying the molecular mechanism involved in the windo…

2021

The human endometrium is a dynamic tissue that only is receptive to host the embryo during a brief time in the middle secretory phase, called the window of implantation (WOI). Despite its importance, regulation of the menstrual cycle remains incompletely understood. The aim of this study was to characterize the gene cooperation and regulation of menstrual cycle progression, to dissect the molecular complexity underlying acquisition of endometrial receptivity for a successful pregnancy, and to provide the scientific community with detailed gene co-expression information throughout the menstrual cycle on a user-friendly web-tool database. A retrospective gene co-expression analysis was perfor…

Embryologysystems biology of the menstrual cycleTranscription Geneticendometrial receptivitymedia_common.quotation_subjectweighted gene correlation network analysis (WGCNA)BiologyCohort StudiesEndometriumgenetic regulation of menstrual cyclePregnancymicroRNAGeneticsHumansEmbryo ImplantationMolecular BiologyGeneTranscription factorgene co-expressionDerepressionMenstrual cycleMenstrual Cycletranscription factormedia_commonrecurrent implantation failuremicroRNAObstetrics and GynecologyGene Expression Regulation DevelopmentalEmbryoCell BiologyGene signatureCell biologyendometrial transcriptomicsnuclear hormone receptorReproductive MedicineNuclear receptorEmbryo LossFemaleTranscriptomeDevelopmental Biology
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