0000000000017866

AUTHOR

Claudio Alvarez

showing 4 related works from this author

Dopamine agonist cabergoline reduces hemoconcentration and ascites in hyperstimulated women undergoing assisted reproduction.

2007

Abstract Context: Ovarian hyperstimulation syndrome (OHSS) results from increased vascular permeability (VP) caused by ovarian hypersecretion of vascular endothelial growth factor (VEGF), which activates its receptor-2. In animals, the dopamine receptor 2 agonist cabergoline (Cb2) inactivates VEGF receptor-2 and prevents increased VP. Objective: Our objective was to test whether Cb2 reduces VP and prevents OHSS in humans. Design: We conducted a prospective, randomized, double-blind study on oocyte donors at risk of developing OHSS (>20 follicles, >12 mm developed, and >20 oocytes retrieved). Interventions: Cb2 0.5 mg/d (n = 37) or a placebo (n = 32) was administered fro…

Endocrinology Diabetes and MetabolismClinical BiochemistryOvarian hyperstimulation syndromeVascular permeabilityHematocritBiochemistrychemistry.chemical_compoundHemoglobinsEndocrinologyPregnancyAscitesImage Processing Computer-AssistedMedicineProspective Studiesmedicine.diagnostic_testReverse Transcriptase Polymerase Chain ReactionObstetrics and GynecologyAscitesGeneral MedicineHemoconcentrationMagnetic Resonance ImagingVascular endothelial growth factorHematocritDopamine AgonistsFemalemedicine.symptommedicine.drugAgonistAdultmedicine.medical_specialtyCabergolinemedicine.drug_classContext (language use)Fertilization in VitroDopamine agonistOvarian Hyperstimulation SyndromeDouble-Blind MethodInternal medicineCabergolineLuteal CellsHumansErgolinesGranulosa Cellsbusiness.industryReceptors Dopamine D2Peritoneal fluidBiochemistry (medical)Ovarymedicine.diseaseEndocrinologychemistryRegional Blood FlowbusinessExtracellular SpaceThe Journal of clinical endocrinology and metabolism
researchProduct

Antral follicle count (AFC) can be used in the prediction of ovarian response but cannot predict the oocyte/embryo quality or the in vitro fertilizat…

2007

To verify whether the antral follicle count (AFC) could predict ovarian response, oocyte/embryo quality, and IVF outcome.Prospective study.Instituto Universitario-Instituto Valenciano de Infertilidad, Valencia, Spain.One thousand seventy-four donors and 975 oocyte recipient cycles.Controlled ovarian hyperstimulation (COH), endometrial preparation, IVF/intracytoplasmic sperm injection, ET.COH and oocyte/embryo quality parameters and IVF outcome.We observed lower E(2) levels and fewer mature retrieved oocyte numbers among donors who showed an AFC that was10. These donors also showed significantly higher cancellation and no-donation rates; poor and/or insufficient response was the principal ca…

Adultmedicine.medical_specialtymedicine.medical_treatmentEmbryonic DevelopmentOocyte RetrievalCell CountFertilization in VitroControlled ovarian hyperstimulationIntracytoplasmic sperm injectionAndrologyYoung AdultEgg donationOvarian FollicleEmbryo cryopreservationPredictive Value of TestsPregnancymedicineHumansUltrasonographyGynecologyIn vitro fertilisationOocyte Donationbusiness.industryPatient SelectionOvaryPregnancy OutcomeObstetrics and GynecologyFertility Agents FemaleEmbryo MammalianAntral follicleEmbryo transferReproductive MedicineSpainFertilizationVaginaembryonic structuresOocytesFemaleLeuprolidebusinessGonadotropinsEmbryo qualityFertility and Sterility
researchProduct

The role of thrombophilia and thyroid autoimmunity in unexplained infertility, implantation failure and recurrent spontaneous abortion.

2007

The role of thrombophilia and thyroid autoimmunity in unexplained infertility (UI), implantation failure (IF) and recurrent spontaneous abortion (RSA) is controversial and poorly understood.From March, 2004 to January, 2007, 119 women were prospectively included: 32 oocyte donors, 31 patients with UI, 26 with IF and 30 with RSA. The IF and RSA groups presented normal preimplantation genetic screening. Protein C, protein S, antithrombin III, lupus anticoagulant, activated protein C resistance (APCR), immunoglobulin M and G anticardiolipin antibodies, homocystine, Factor V Leiden, prothrombin G20210A mutation, methylentetrahydrofolate reductase C677T mutation, thyroid-stimulating hormone (TSH…

Adultendocrine systemmedicine.medical_specialtyAbortion Habitualmedicine.medical_treatmentThyroid GlandAutoimmunityThrombophiliaGastroenterologyIodide PeroxidaseThyroglobulinAntiphospholipid syndromeInternal medicinemedicineFactor V LeidenPrevalenceHumansThrombophiliaEmbryo ImplantationProspective StudiesUnexplained infertilityActivated Protein C ResistanceAutoantibodiesLupus anticoagulantbusiness.industryRehabilitationThyroidObstetrics and Gynecologymedicine.diseaseEndocrinologymedicine.anatomical_structureReproductive MedicineLupus Coagulation InhibitorThyroglobulinFemaleActivated protein C resistancebusinessInfertility FemaleHuman reproduction (Oxford, England)
researchProduct

Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women und…

2007

Background Ovarian hyperstimulation syndrome (OHSS) is a result of ovarian overexpression of vascular endothelial growth factor (VEGF) and its receptor 2 (VEGFR2). VEGF/VEGFR2 binding disrupts cellular junctions and increases vascular permeability (VP), a characteristic of OHSS, but enhances angiogenesis, which is a fundamental step in implantation. In animals, the dopamine agonist Cabergoline (Cb2) prevents VP without affecting angiogenesis. In humans, Cb2 averts OHSS, but a possible detrimental effect on angiogenesis and implantation has not been explored. A pilot study was designed to analyze whether or not Cb2 administration, as a procedure for preventing OHSS, affects the outcome of as…

Adultmedicine.medical_specialtyCabergolinePregnancy RateReproductive Techniques AssistedOvarian hyperstimulation syndromePilot ProjectsBiologyDopamine agonistAndrologyOvarian Hyperstimulation Syndromechemistry.chemical_compoundPregnancyCabergolineInternal medicinemedicineHumansEmbryo ImplantationErgolinesOvarian follicleRetrospective StudiesPregnancyRehabilitationObstetrics and Gynecologymedicine.diseaseVascular endothelial growth factorPregnancy ratemedicine.anatomical_structureEndocrinologyReproductive MedicinechemistryDopamine AgonistsGestationFemalemedicine.drugHuman Reproduction
researchProduct