Author: Laura Martínez

Detailed Anatomical and Electrophysiological Models of Human Atria and Torso for the Simulation of Atrial Activation

2015

Atrial arrhythmias, and specifically atrial fibrillation (AF), induce rapid and irregular activation patterns that appear on the torso surface as abnormal P-waves in electrocardiograms and body surface potential maps (BSPM). In recent years both P-waves and the BSPM have been used to identify the mechanisms underlying AF, such as localizing ectopic foci or high-frequency rotors. However, the relationship between the activation of the different areas of the atria and the characteristics of the BSPM and P-wave signals are still far from being completely understood. In this work we developed a multi-scale framework, which combines a highly-detailed 3D atrial model and a torso model to study th…

Models Anatomicmedicine.medical_specialtyBODY-SURFACEVOLUME CONDUCTORCANINE RIGHTlcsh:MedicineTECNOLOGIA ELECTRONICAInternal medicineAtrial FibrillationBody surfacemedicineHumansSinus rhythmHeart Atrialcsh:ScienceFibrillationMultidisciplinaryP-WAVEmedicine.diagnostic_testbusiness.industrylcsh:RBody Surface Potential MappingP waveTorsoAtrial fibrillationAnatomyTorsoAtrial Functionmedicine.diseaseHUMAN HEARTRATE-DEPENDENCEElectrophysiologymedicine.anatomical_structurecardiovascular systemCardiologylcsh:QFIBRILLATIONmedicine.symptomSINUS RHYTHMbusinessElectrocardiographyCONDUCTION-VELOCITYResearch ArticleACTION-POTENTIALS

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Analysis of in-silico body surface P-wave integral maps show important differences depending on the connections between coronary sinus and left atrium

2016

The electrical connections between the atrial coronary sinus (CS) and the left atrial (LA) myocardium have an effect on the overall atrial activation pattern and the P-wave morphology. In this study, we use our validated multi-scale 3D human atrial-torso model to elucidate which electro-anatomical configuration of connections between CS and LA more accurately reproduces a set of body surface P-wave integral maps (BSPiM) acquired in the clinic. We performed atrial biophysical simulations by pacing in distal and proximal LA sites. The corresponding in-silico BSPiM were then computed and compared with published clinical patterns obtained from patients. Important differences in BSPiM were obser…

medicine.medical_specialty0206 medical engineeringP waveLeft atrium02 engineering and technologyAnatomyAtrial activation020601 biomedical engineering030218 nuclear medicine & medical imaging03 medical and health sciencesOstium0302 clinical medicinemedicine.anatomical_structureLeft atrialInternal medicineBody surfacecardiovascular systemmedicineCardiologycardiovascular diseasesCoronary sinusMathematics

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Shine bright or live long: substituent effects in [Cu(N^N)(P^P)]+-based light-emitting electrochemical cells where N^N is a 6-substituted 2,2'-bipyri…

2016

We report [Cu(P^P)(N^N)][PF6] complexes with P^P = bis(2-(diphenylphosphino)phenyl)ether (POP) or 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (xantphos) and N^N = 6-methyl-2,2′-bipyridine (Mebpy), 6-ethyl-2,2′-bipyridine (Etbpy), 6,6′-dimethyl-2,2′-bipyridine (Me2bpy) or 6-phenyl-2,2′-bipyridine (Phbpy). The crystal structures of [Cu(POP)(Phbpy)][PF6]·Et2O, [Cu(POP)(Etbpy)][PF6]·Et2O, [Cu(xantphos)(Me2bpy)][PF6], [Cu(xantphos)(Mebpy)][PF6]·CH2Cl2·0.4Et2O, [Cu(xantphos)(Etbpy)][PF6]·CH2Cl2·1.5H2O and [Cu(xantphos)(Phbpy)][PF6] are described; each copper(I) centre is distorted tetrahedral. In the crystallographically determined structures, the N^N domain in [Cu(xantphos)(Phbpy)]+ and [Cu(…

XantphosLigand02 engineering and technologyGeneral ChemistryCrystal structureNuclear magnetic resonance spectroscopy010402 general chemistry021001 nanoscience & nanotechnology01 natural sciences22'-Bipyridine0104 chemical scienceschemistry.chemical_compoundCrystallographyElectron transferchemistryExcited stateMaterials ChemistrySinglet state0210 nano-technology

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Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Propert…

2015

[EN] Background¿ Ventricular fibrillation (VF) has been proposed to be maintained by localized high-frequency sources. We tested whether spectral-phase analysis of the precordial ECG enabled identification of periodic activation patterns generated by such sources. Methods and Results¿Precordial ECGs were recorded from 15 ischemic cardiomyopathy and 15 Brugada syndrome (type 1 ECG) patients during induced VF and analyzed in the frequency-phase domain. Despite temporal variability, induced VF episodes lasting 19.6±7.9 s displayed distinctly high power at a common frequency (shared frequency, 5.7±1.1 Hz) in all leads about half of the time. In patients with Brugada syndrome, phase analysis of …

Adultmedicine.medical_specialty5electrocardiographyInfarctionVentricular tachycardiaTECNOLOGIA ELECTRONICAElectrocardiographyPhysiology (medical)Internal medicinemedicineHumansBrugada syndromeMyocardial infarctioncardiovascular diseasesVentricular fibrillationBrugada syndromeAgedFibrillationIschemic cardiomyopathymedicine.diagnostic_testbusiness.industry106Original ArticlesMiddle Agedmedicine.diseaseventricular fibrillationMyocardial infarctionmyocardial infarctionVentricular TachycardiaAnesthesiaVentricular fibrillationCardiologyComputingMethodologies_DOCUMENTANDTEXTPROCESSINGTachycardia Ventricularmedicine.symptomCardiology and Cardiovascular MedicinebusinessCardiomyopathiesElectrophysiologic Techniques CardiacElectrocardiography

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Non-invasive localization of atrial ectopic beats by using simulated body surface P-wave integral maps

2017

Non-invasive localization of continuous atrial ectopic beats remains a cornerstone for the treatment of atrial arrhythmias. The lack of accurate tools to guide electrophysiologists leads to an increase in the recurrence rate of ablation procedures. Existing approaches are based on the analysis of the P-waves main characteristics and the forward body surface potential maps (BSPMs) or on the inverse estimation of the electric activity of the heart from those BSPMs. These methods have not provided an efficient and systematic tool to localize ectopic triggers. In this work, we propose the use of machine learning techniques to spatially cluster and classify ectopic atrial foci into clearly diffe…

TachycardiaPhysiologyComputer sciencemedicine.medical_treatment02 engineering and technology030204 cardiovascular system & hematologyBioinformaticsBiochemistryACTIVATIONElectrocardiography0302 clinical medicineHeart RateAtrial FibrillationMedicine and Health SciencesImage Processing Computer-AssistedDEPOLARIZATIONBody surface P-wave integral mapsCardiac AtriaAtrial ectopic beatsMultidisciplinarymedicine.diagnostic_testORIGINApplied MathematicsSimulation and ModelingP waveBody Surface Potential MappingQRHeartHUMANSaarhythmiasAblationANATOMYBioassays and Physiological Analysismachine learningPhysical SciencesAtrial ectopic beatsMedicineAtrial Premature ComplexesFIBRILLATIONmedicine.symptomTACHYCARDIAAlgorithmsResearch ArticleclusteringTachycardia Ectopic AtrialComputer and Information SciencesSVMScienceCORONARY-SINUS0206 medical engineeringCardiologyResearch and Analysis MethodsMembrane PotentialTECNOLOGIA ELECTRONICAMachine Learning Algorithms03 medical and health sciencesArtificial IntelligenceHeart Conduction SystemSupport Vector MachinesBody surfacemedicineComputer SimulationHeart AtriaCoronary sinusFibrillationbusiness.industryElectrophysiological TechniquesBiology and Life SciencesPattern recognitionAtrial arrhythmiasELECTROPHYSIOLOGY020601 biomedical engineeringMODELElectrophysiologyCardiovascular AnatomyCardiac ElectrophysiologyArtificial intelligencebusinessElectrocardiographyBiomarkersMathematics

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Factors affecting basket catheter detection of real and phantom rotors in the atria: A computational study

2018

[EN] Anatomically based procedures to ablate atrial fibrillation (AF) are often successful in terminating paroxysmal AF. However, the ability to terminate persistent AF remains disappointing. New mechanistic approaches use multiple-electrode basket catheter mapping to localize and target AF drivers in the form of rotors but significant concerns remain about their accuracy. We aimed to evaluate how electrode-endocardium distance, far-field sources and inter-electrode distance affect the accuracy of localizing rotors. Sustained rotor activation of the atria was simulated numerically and mapped using a virtual basket catheter with varying electrode densities placed at different positions withi…

Ablation TechniquesNormalization propertyTime FactorsPhysiologymedicine.medical_treatmentAction Potentials02 engineering and technology030204 cardiovascular system & hematologylaw.invention0302 clinical medicineModelslawHeart RateMedicine and Health SciencesMapping cathetersCardiac Atrialcsh:QH301-705.5Numerical AnalysisEcologyRotor (electric)HeartAblationElectrophysiologyComputational Theory and Mathematicsmedicine.veinModeling and SimulationRotorsPhysical SciencesInferior Vena CavaEngineering and TechnologyAnatomyBasket catheterArrhythmiaInterpolationResearch ArticleBiotechnologyMaterials scienceCatheters0206 medical engineeringPhase (waves)CardiologyInferior vena cavaModels BiologicalMembrane PotentialImaging phantomVeinsTECNOLOGIA ELECTRONICA03 medical and health sciencesCellular and Molecular NeuroscienceAblation Techniques; Action Potentials; Atrial Fibrillation; Computational Biology; Computer Simulation; Heart Atria; Heart Conduction System; Heart Rate; Humans; Models Biological; Time FactorsHeart Conduction SystemPhase analysisGeneticsmedicineHumansComputer SimulationHeart AtriaMolecular BiologyEcology Evolution Behavior and SystematicsMechanical EngineeringComputational BiologyBiology and Life SciencesBiological020601 biomedical engineeringAtrial fibrillationInterpolationlcsh:Biology (General)Cardiovascular AnatomyBlood VesselsMedical Devices and EquipmentMathematicsBiomedical engineeringEndocardium

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