0000000000042687

AUTHOR

H. Osman

showing 7 related works from this author

A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts

2020

Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and high assay sensitivity as viral loads in cerebrospinal fluid samples from meningitis and sepsis clinical presentation can be extremely low. This study evaluated the sensitivity and specificity of currently used commercial and in‐house diagnostic and typing assays. Accurately quantified RNA transcript controls were distributed to 27 diagnostic and 12 reference laboratories in 17 European countries for blinded testing. Transcripts represented the four human EV…

EchovirusGene DosageDIVERSITYCHILDRENmedicine.disease_causelaw.invention0302 clinical medicinelawEPIDEMIOLOGY030212 general & internal medicineResearch ArticlesComputingMilieux_MISCELLANEOUSPolymerase chain reaction*enterovirus*enterovirus A7111832 Microbiology and virologyenterovirusRNA transcripts[SDE.IE]Environmental Sciences/Environmental EngineeringHuman parechovirusCLINICAL-SAMPLESASSOCIATIONMeningitis Viral3. Good healthEuropeenterovirus A71PCRInfectious Diseases*RNA transcriptsINFECTIONS[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology*PCRRNA Viral030211 gastroenterology & hepatologyLife Sciences & BiomedicineViral loadResearch Article[SDE.MCG]Environmental Sciences/Global ChangesBiologyReal-Time Polymerase Chain ReactionSensitivity and SpecificityPANEL03 medical and health sciencesCEREBROSPINAL-FLUIDVirologyEnterovirus InfectionsmedicineHumansRHINOVIRUSTypingparechovirusScience & TechnologyPicornaviridae InfectionsReproducibility of ResultsGold standard (test)biology.organism_classification[SDE.ES]Environmental Sciences/Environmental and SocietyVirology*parechovirusMolecular TypingParechovirusEnterovirusReagent Kits Diagnostic[SDE.BE]Environmental Sciences/Biodiversity and EcologyJournal of Medical Virology
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Elicitins trap and transfer sterols from micelles, liposomes and plant plasma menbranes

1999

International audience

[SDV] Life Sciences [q-bio]PHYTOPHTORA[SDV]Life Sciences [q-bio]LIPOSOME (ORGANITE)ComputingMilieux_MISCELLANEOUS
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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

2021

Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…

MaleCOVID-19 Vaccinesafe surgery; vaccination modelling; COVID-19Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]MULTICENTERComorbidity030230 surgery0302 clinical medicinephase 3 clinical trial (topic)Case fatality rateProspective StudiesSARS-CoV-2 Vaccination Safe surgeryCOVID-19/epidemiologySARS-CoV-2 ; vaccination ; safe surgeryeducation.field_of_studycase fatality rateVaccinationVaccinationAdolescent; Adult; Aged; COVID-19; COVID-19 Vaccines; Comorbidity; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Postoperative Complications; Preoperative Period; Prospective Studies; SARS-CoV-2; Vaccination; Young Adulthealth care policyElective Surgical Procedures030220 oncology & carcinogenesisvaccination modellingPreoperative PeriodCOVID-19; SARS-CoV-2; cancer; vaccination; outcome; mortality; infection; modellingCohort studyprospective studyHumanmedicine.medical_specialtyArticle03 medical and health sciencesSARS-CoV-2 vaccinationSDG 3 - Good Health and Well-beingCOVID-19 Vaccines/pharmacologyHumansVaccination/methodsElective surgeryeducationAgedScience & TechnologyElective Surgical Procedureadult; aged; Article; cancer grading; cancer surgery; case fatality rate; computer assisted tomography; elective surgery; female; follow up; health care policy; human; incidence; infection rate; infection risk; major clinical study; male; middle aged; mortality; outcome assessment; phase 3 clinical trial (topic); preoperative care; prospective study; sensitivity analysis; seroprevalence; Severe acute respiratory syndrome coronavirus 2; vaccination; young adult; COVID-19; COVID-19 Vaccines; Comorbidity; Elective Surgical Procedures; Postoperative Complications; Preoperative Period; SARS-CoV-2; Vaccination; surgery.Cura preoperatòriamajor clinical studymortalityinfectionProspective StudieincidenceSurgeryHuman medicinePostoperative Complication610 Medizin und GesundheitAcademicSubjects/MED00910Settore MED/18 - CHIRURGIA GENERALESettore MED/29 - CHIRURGIA MAXILLOFACCIALEcomputer assisted tomographyESTUDOS PROSPECTIVOSsurgerysafe surgeryPostoperative Complicationssensitivity analysisSevere acute respiratory syndrome coronavirus 2preoperative careVacunacióProspective cohort studyseroprevalenceIncidence (epidemiology)covidElective Surgical Procedures/methodsMiddle Agedcancer gradingCOVID vaccinationoutcome/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingSARS-CoV-2; vaccination; surgeryOriginal ArticleFemalecancer surgeryAcademicSubjects/MED00010Life Sciences & BiomedicineAdultCOVID-19 VaccinesAdolescentinternational prospective cohort studyPostoperative Complications/prevention & controlPopulationinfection rateSARS-CoV-2/immunologyNOmodellingYoung Adultmedicinefollow upcancerddc:610infection riskoutcome assessmentLS7_4business.industrySARS-CoV-2Number needed to vaccinatePreoperative careCOVID-193126 Surgery anesthesiology intensive care radiologySettore MED/18Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]elective surgeryEmergency medicinebusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyThe British Journal of Surgery
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Effects of 12 beticolins, Cercospora beticola toxins, on proliferation of ras-transformed adrenocortical cell

2001

International audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]ComputingMilieux_MISCELLANEOUS
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Combination of the novel farnesyltransferase inhibitor RPR 130401 and the gerannylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activat…

1999

International audience

RAT[SDV.BC]Life Sciences [q-bio]/Cellular BiologyTECHNIQUE DES TRACEURS[SDV.BC] Life Sciences [q-bio]/Cellular BiologyCANCERComputingMilieux_MISCELLANEOUS
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Géranylgéranylation et farnésylation des protéines Ras dans les cellules corticosurrénales transformées par l'oncogène rasEJ; l'effet antiproliférati…

1997

150 ref. *INRA Dijon, Documentation, 17 rue Sully, BP 86510, 21065 Dijon cedex Diffusion du document : INRA Dijon, Documentation, 17 rue Sully, BP 86510, 21065 Dijon cedex Diplôme : Dr. d'Université

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]these
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Geranylgeranyl as well as farnesyl moiety is transferred to Ras p21 overproduced in adrenocortical cells transformed by c-Ha-ras oncogene

1997

International audience

CULTURE DE CELLULE[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologyRAT[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyComputingMilieux_MISCELLANEOUS
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