0000000000043405

AUTHOR

Sara Seitun

showing 14 related works from this author

Prevalence and characteristics of coronary artery disease in a population with suspected ischaemic heart disease using CT coronary angiography: corre…

2008

Purpose. This study was undertaken to describe the correlation between the distribution of coronary artery disease (CAD) in a symptomatic population with suspected ischaemic heart disease, cardiovascular risk factors (RF) and clinical presentation. Materials and methods. We studied 163 patients (mean age 65.5 years; 101 men and 62 women) referred for multidetector computed tomography coronary angiography (MDCT-CA) to rule out CAD. The patients had no prior history of revascularisation or myocardial infarction. We analysed how the characteristics of CAD (severity and type of plaque) can change with the increase in RF and how they are related to different clinical presentations. Results. Pati…

Malemedicine.medical_specialtyCT coronary angiographyPopulationMyocardial IschemiaCoronary Artery DiseaseCoronary AngiographySensitivity and SpecificityCoronary artery diseasePredictive Value of TestsInternal medicineEpidemiologyPrevalencemedicineHumansrisk factorsRadiology Nuclear Medicine and imagingMyocardial infarctioneducationAgedNetherlandsNeuroradiologyeducation.field_of_studyFramingham Risk Scoremedicine.diagnostic_testbusiness.industryReproducibility of Resultssuspected coronary artery diseaseInterventional radiologyGeneral MedicineMiddle Agedmedicine.diseaseCT coronary angiography Risk factors Epidemiology Suspected coronary artery diseaseCardiologyFemaleepidemiologyPresentation (obstetrics)Tomography X-Ray ComputedSettore MED/36 - Diagnostica Per Immagini E RadioterapiabusinessRadiologia Medica
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Rationale, design and methods of CTCA-PRORECAD (Computed Tomography Coronary Angiography Prognostic Registry for Coronary Artery Disease): a multicen…

2013

PURPOSE: This study was done to assess the prognostic value of computed tomography coronary angiography (CTCA) in a large multicentre population of patients with suspected coronary artery disease (CAD) and, in particular, its incremental value compared with traditional methods for risk stratification. MATERIALS AND METHODS: This is a retrospective observational study that began in January 2003 conducted on patients with suspected CAD assessed with CTCA on the basis of symptoms (chest pain, dyspnoea) and/or abnormal or equivocal stress test and/or a high cardiovascular risk profile. The participating centres will provide data obtained with CTCA performed with 16-slice or higher equipment. Ex…

Coronary angiographyMaleContrast MediaComputed tomographyCoronary DiseaseCoronary AngiographyCoronary artery diseaseComputed tomography coronary angiographyCoronary artery diseaseComputer-AssistedRisk FactorsRegistriesTomographyNeuroradiologyeducation.field_of_studymedicine.diagnostic_testcomputed tomography coronary angiography; coronary artery disease; prevalence of disease; prognosis; registry; risk stratificationRadiographic Image InterpretationInterventional radiologyGeneral MedicineMiddle AgedPrognosisX-Ray ComputedResearch DesignRisk stratificationCardiologyPrevalence of diseaseRadiographic Image Interpretation Computer-AssistedFemaleRadiologymedicine.medical_specialtyRegistryPrognosiEndpoint DeterminationPopulationRisk AssessmentComputed tomography coronary angiography; Coronary artery disease; Prevalence of disease; Prognosis; Risk stratification; Registry; Analysis of Variance; Contrast Media; Coronary Disease; Endpoint Determination; Female; Humans; Male; Middle Aged; Prognosis; Proportional Hazards Models; Radiographic Image Interpretation Computer-Assisted; Retrospective Studies; Risk Assessment; Risk Factors; Coronary Angiography; Registries; Research Design; Tomography X-Ray ComputedInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingeducationRisk stratificationProportional Hazards ModelsRetrospective StudiesAnalysis of Variancebusiness.industrymedicine.diseasebusinessTomography X-Ray ComputedLa Radiologia medica
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Influence of image reconstruction parameters on cardiovascular risk reclassification by Computed Tomography Coronary Artery Calcium Score

2018

Objective: To investigate the influence of different CT reconstruction parameters on coronary artery calcium scoring (CACS) values and reclassification of predicted cardiovascular (CV) risk. Methods: CACS was evaluated in 113 patients undergoing ECG-gated 64-slice CT. Reference CACS protocol included standard kernel filter (B35f) with slice thickness/increment of 3/1.5 mm, and field-of-view (FOV) of 150–180 mm. Influence of different image reconstruction algorithms (reconstructed slice thickness/increment 2.0/1.0–1.5/0.8–3.0/2.0–3.0/3.0 mm; slice kernel B30f-B45f; FOV 200–250 mm) on Agatston score was assessed by Bland-Altman plots and concordance correlation coefficient (CCC) ana…

MaleAccuracy and precisionRadiology Nuclear Medicine and ImagingCardiac computed tomographyComputed Tomography AngiographyComputed tomographyIterative reconstructionCoronary Artery Disease030204 cardiovascular system & hematologyRisk Assessment030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicineImage reconstruction algorithmRisk FactorsImage Processing Computer-AssistedMedicineHumansReconstruction parameterProspective StudiesVascular CalcificationAgedReconstruction parametersmedicine.diagnostic_testCoronary artery calcium scorebusiness.industryCoronary artery calcium scoreCardiovascular risk classificationGeneral MedicineMiddle AgedCardiovascular riskConcordance correlation coefficientCardiovascular DiseasesCardiac computed tomography; Cardiovascular risk; Cardiovascular risk classification; Coronary artery calcium score; Reconstruction parametersFemalebusinessAgatston scoreNuclear medicineSettore MED/36 - Diagnostica Per Immagini E RadioterapiaCoronary Artery Calcium ScoringAlgorithms
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Appropriateness criteria for the use of cardiac computed tomography, SIC-SIRM part 2: Acute chest pain evaluation; Stent and coronary artery bypass g…

2022

In the past 20 years, cardiac computed tomography (CCT) has become a pivotal technique for the noninvasive diagnostic workup of coronary and cardiac diseases. Continuous technical and methodological improvements, combined with fast growing scientific evidence, have progressively expanded the clinical role of CCT. Randomized clinical trials documented the value of CCT in increasing the cost-effectiveness of the management of patients with acute chest pain presenting in the emergency department, also during the pandemic. Beyond the evaluation of stents and surgical graft patency, the anatomical and functional coronary imaging have the potential to guide treatment decision-making and planning …

Chest PainHeart DiseasesInterventionalCardiologyGeneral Medicineheart diseaseRadiology Interventionalvalve diseaseX-Ray Computedcoronary computed tomography scancoronary artery bypass graftNeoplasmsHumansStentsstentCoronary Artery BypassCardiology and Cardiovascular MedicineTomography X-Ray ComputedCardiomyopathiesRadiologychest pain; coronary artery bypass graft; coronary computed tomography scan; heart disease; stent; valve disease; Chest Pain; Coronary Artery Bypass; Humans; Radiology Interventional; Stents; Tomography X-Ray Computed; Cardiology; Cardiomyopathies; Heart Diseases; NeoplasmsTomographyvalve disease.
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SIRM–SIC appropriateness criteria for the use of Cardiac Computed Tomography. Part 1: Congenital heart diseases, primary prevention, risk assessment …

2021

AbstractIn the past 20 years, Cardiac Computed Tomography (CCT) has become a pivotal technique for the noninvasive diagnostic work-up of coronary and cardiac diseases. Continuous technical and methodological improvements, combined with fast growing scientific evidence, have progressively expanded the clinical role of CCT. Recent large multicenter randomized clinical trials documented the high prognostic value of CCT and its capability to increase the cost-effectiveness of the management of patients with suspected CAD. In the meantime, CCT, initially perceived as a simple non-invasive technique for studying coronary anatomy, has transformed into a multiparametric “one-stop-shop” approach abl…

genetic structuresCardiac computed tomographyComputed Tomography AngiographyCoronary DiseaseCAD030204 cardiovascular system & hematologyChest painChest pain Congenital heart disease Coronary CT angiography Epicardial adipose tissue Plaque Stenosislaw.inventionChest painCongenital0302 clinical medicineRandomized controlled triallaw030212 general & internal medicineHeart DefectsPlaqueNeuroradiologyStenosismedicine.diagnostic_testCalcinosisHeartInterventional radiologyGeneral MedicineFractional Flow ReserveFractional Flow Reserve MyocardialPrimary PreventionPosition PaperChest pain; Congenital heart disease; Coronary CT angiography; Epicardial adipose tissue; Plaque; Stenosis; Calcinosis; Coronary Disease; Coronary Stenosis; Fractional Flow Reserve Myocardial; Heart; Heart Defects Congenital; Humans; Primary Prevention; Cardiac Imaging Techniques; Computed Tomography Angiography; Preoperative Caremedicine.symptomRisk assessmentHeart Defects Congenitalmedicine.medical_specialty03 medical and health sciencesEpicardial adipose tissuePreoperative CaremedicineMyocardialHumansRadiology Nuclear Medicine and imagingCoronary CT angiographyIntensive care medicineCongenital heart diseasebusiness.industryCoronary Stenosismedicine.diseaseCardiac Imaging TechniquesStenosisbusinessLa radiologia medica
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Myocardial blood flow quantification for evaluation of coronary artery disease by computed tomography

2017

During the last decade coronary computed tomography angiography (CTA) has become the preeminent non-invasive imaging modality to detect coronary artery disease (CAD) with high accuracy. However, CTA has a limited value in assessing the hemodynamic significance of a given stenosis due to a modest specificity and positive predictive value. In recent years, different CT techniques for detecting myocardial ischemia have emerged, such as CT-derived fractional flow reserve (FFR-CT), transluminal attenuation gradient (TAG), and myocardial CT perfusion (CTP) imaging. Myocardial CTP imaging can be performed with a single static scan during first pass of the contrast agent, with monoenergetic or dual…

medicine.medical_specialtyCardiac computed tomographyMyocardial blood flow quantificationPerfusion scanningFractional flow reserveReview Article030204 cardiovascular system & hematology030218 nuclear medicine & medical imagingCoronary artery disease03 medical and health sciencesMyocardial perfusion imaging0302 clinical medicineStress imagingInternal medicinemedicinemedicine.diagnostic_testbusiness.industryMyocardial perfusion imagingmedicine.diseaseRegadenosonDipyridamoleCoronary artery disease (CAD)StenosisCardiologyRadiologyCoronary vasodilatorbusinessCardiology and Cardiovascular MedicineSettore MED/36 - Diagnostica Per Immagini E Radioterapiamedicine.drug
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Intravenous Contrast Material for Cardiac Computed Tomography

2023

Purpose: The Italian Registry of Contrast Material use in Cardiac Computed Tomography (iRCM-CCT) is a multicenter, multivendor, observational study on the use of contrast media (CM) in patients undergoing cardiac computed tomography (CCT). The aim of iRCM-CCT is to assess image quality and safety profile of intravenous CM compounds. Materials and methods: iRCM-CCT enrolled 1842 consecutive patients undergoing CCT (≥50 per site) at 20 cluster sites with the indication of suspected coronary artery disease. Demographic characteristics, CCT, and CM protocols, clinical indications, safety markers, radiation dose reports, qualitative (ie, poor vascular enhancement) and quantitative (ie, HU attenu…

safetyPulmonary and Respiratory MedicineSettore MED/36 - Diagnostica per Immagini e Radioterapiacoronary arteriecomputed tomography angiography; contrast media; coronary arteries; image enhancement; safetyRadiology Nuclear Medicine and imagingcomputed tomography angiography; contrast media; coronary arteries; image enhancement; safety;image enhancementcontrast mediacomputed tomography angiographycoronary arteriesimage enhancement contrast media safetycomputed tomography angiographycoronary arteriesimage enhancementcontrast mediasafetyJournal of Thoracic Imaging
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Computed tomography coronary angiography vs. stress ECG in patients with stable angina

2009

PURPOSE: This study compared the role of multislice computed tomography coronary angiography (MSCT-CA) and stress electrocardiography (ECG) in the diagnostic workup of patients with chronic chest pain. MATERIALS AND METHODS: MSCT-CA was performed in 43 patients (31 men, 12 women, mean age 58.8+/-7.7 years) with stable angina after a routine diagnostic workup involving stress ECG and conventional CA. The following inclusion criteria were adopted: sinus rhythm and ability to hold breath for 12 s. Beta-blockers were administered in patients with heart rate>or=70 beats/minute. In order to identify or exclude patients with significant stenoses (>or=50% lumen), we determined posttest likelihood r…

MaleCoronary angiographystable anginamedicine.medical_specialtyExercise testCoronary angiographyCoronary artery diseaseAngina PectorisImagingCoronary artery diseaseElectrocardiographyPredictive Value of TestsInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingComputed tomographyAgedNeuroradiologymedicine.diagnostic_testbusiness.industryImaging Coronary artery disease Computed tomography Coronary angiography Exercise testUltrasoundInterventional radiologyGeneral MedicineMiddle Agedmedicine.diseasePredictive value of testsCardiologyFemaleRadiologyTomography X-Ray ComputedbusinessElectrocardiographystress ECGAlgorithmsStress ElectrocardiographyLa radiologia medica
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Prognostic value of Morise clinical score, calcium score and computed tomography coronary angiography in patients with suspected or known coronary ar…

2011

Our aim was to determine the prognostic value of computed tomography coronary angiography (CTCA), coronary artery calcium scoring (CACS) and Morise clinical score in patients with known or suspected coronary artery disease (CAD). A total of 722 patients (480 men; 62.7 +/- 10.9 years) who were referred for further cardiac evaluation underwent CACS and contrast-enhanced CTCA to evaluate the presence and severity of CAD. Of these, 511 (71%) patients were without previous history of CAD. Patients were stratified according to the Morise clinical score (low, intermediate, high), to CACS (0-10, 11-100, 101-400, 401-1,000, > 1,000) and to CTCA (absence of CAD, nonsignificant CAD, obstructive CAD…

Coronary angiographyMalemedicine.medical_specialtyCoronary Artery DiseaseCoronary AngiographyMorise scoreRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexComputed tomography coronary angiographyCoronary artery diseaseSDG 3 - Good Health and Well-beingPredictive Value of TestsRisk FactorsInternal medicineSeverity of illnessmedicineHumansRadiology Nuclear Medicine and imagingcardiovascular diseasesSurvival analysisNeuroradiologyAgedRetrospective Studiesmedicine.diagnostic_testbusiness.industryCalcinosisRetrospective cohort studyInterventional radiologyGeneral MedicineMiddle Agedmedicine.diseasePrognosisSurvival AnalysisCalcium scoreComputed tomography coronary angiography Prognostic value Prognosis Calcium score Morise scorePredictive value of testsCardiologyFemaleRadiologySettore MED/36 - Diagnostica Per Immagini E RadioterapiabusinessTomography X-Ray ComputedPrognostic valueCARDIAC CTAlgorithmsFollow-Up Studies
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Coronary CT angiography: a guide to examination, interpretation, and clinical indications

2021

Introduction: The introduction of Cardiac Computed Tomography (CCT) has changed the paradigm in the field of diagnostic cardiovascular medicine. CCT is the primary tool in the assessment of suspected Coronary Artery Disease (CAD) and should be followed by functional assessment when needed to stratify disease and to plan potential interventional or surgical therapy. Areas Covered: We provided the current state of the knowledge on the main aspects of technique of examination, image interpretation and clinical indications. We have focused our attention on the basic routine applications and activities. Expert Opinion: The primary role of CCT in suspected CAD will progressively become the standa…

medicine.medical_specialtygenetic structuresCardiac computed tomographyComputed Tomography Angiographycardiac ct030204 cardiovascular system & hematologyCoronary AngiographyCoronary artery disease03 medical and health sciences0302 clinical medicineatherosclerosipreventionInternal MedicinemedicineHumansCAD030212 general & internal medicineExamination interpretationskin and connective tissue diseasesbusiness.industryomt.HeartCoronary ct angiographyGeneral Medicinemedicine.diseaseeye diseasessense organsRadiologyTomography X-Ray ComputedCardiology and Cardiovascular Medicinebusinesscoronary artery disease
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Prognostic value of cardiac CT

2020

In the past decades, coronary computed tomography angiography (CCTA) has become a powerful tool in the management of coronary artery disease. The diagnostic and prognostic value of CCTA has been extensively demonstrated in both large observational studies and clinical trials among stable chest pain patients. The quantification of coronary artery calcium score (CACS) is a well-established predictor of cardiovascular morbidity and mortality in asymptomatic subjects. Besides CACS, the main strength of CCTA is the accurate assessment of the individual total atherosclerotic plaque burden, which holds important prognostic information. In addition, CCTA, by providing detailed information on corona…

medicine.medical_specialtyPrognosiComputed Tomography Angiographymedicine.medical_treatmentPerfusion scanningFractional flow reserveCoronary Artery DiseaseCoronary AngiographyRevascularizationChest painAsymptomatic030218 nuclear medicine & medical imagingCoronary computed tomographyCoronary artery diseaseChest pain03 medical and health sciences0302 clinical medicineInternal medicinemedicineCardiac CTHumansRadiology Nuclear Medicine and imagingCADVascular CalcificationNeuroradiologyFFR-CTRisk assessmentRandomized Controlled Trials as TopicVascular Calcification.Asymptomatic Diseasemedicine.diagnostic_testbusiness.industryCACSInterventional radiologyHeartGeneral MedicinePrognosismedicine.diseaseCardiovascular imaging030220 oncology & carcinogenesisAtherosclerosiAsymptomatic DiseasesCardiologyRisk factormedicine.symptomStratificationbusiness
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Coronary calcium score and computed tomography coronary angiography in high-risk asymptomatic subjects: assessment of diagnostic accuracy and prevale…

2010

The aim of the study was to compare the coronary artery calcium score (CACS) and computed tomography coronary angiography (CTCA) for the assessment of non-obstructive/obstructive coronary artery disease (CAD) in high-risk asymptomatic subjects. Two hundred and thirteen consecutive asymptomatic subjects (113 male; mean age 53.6 +/- 12.4 years) with more than one risk factor and an inconclusive or unfeasible non-invasive stress test result underwent CACS and CTCA in an outpatient setting. All patients underwent conventional coronary angiography (CAG). Data from CACS (threshold for positive image: Agatston score 1/100/1,000) and CTCA were compared with CAG regarding the degree of CAD (non-obst…

AdultMalemedicine.medical_specialtyLumen (anatomy)Coronary Artery DiseaseCoronary AngiographyAsymptomaticRisk AssessmentCoronary artery diseaseYoung AdultRisk FactorsInternal medicinePositive predicative valuemedicinePrevalenceHumansRadiology Nuclear Medicine and imagingcardiovascular diseasesRisk factorNeuroradiologyAgedbusiness.industrynutritional and metabolic diseasesCalcinosiscalcium scoreGeneral MedicineMiddle Agedmedicine.diseaseCoronary Calcium ScoreItalycardiovascular systemCardiologyFemaleRadiologymedicine.symptomSettore MED/36 - Diagnostica Per Immagini E RadioterapiaAgatston scorebusinessTomography X-Ray Computednon-obstructive coronary artery diseaseEuropean Radiology
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Low dose CT of the heart: a quantum leap into a new era of cardiovascular imaging.

2010

In 10 years, computed tomography coronary angiography (CTCA) has shifted from an investigational tool to clinical reality. Even though CT technologies are very advanced and widely available, a large body of evidence supporting the clinical role of CTCA is missing. The reason is that the speed of technological development has outpaced the ability of the scientific community to demonstrate the clinical utility of the technique. In addition, with each new CT generation, there is a further broadening of actual and potential applications. In this review we examine the state of the art on CTCA. In particular, we focus on issues concerning technological development, radiation dose, implementation,…

Coronary angiographymedicine.medical_specialtyCardiologyComputed tomographycardiac CTCoronary DiseaseCoronary AngiographyRadiation DosageCoronary artery diseaseComputed tomography coronary angiographyCoronary artery diseasemedicineTrainingLow dose ctHumansRadiology Nuclear Medicine and imagingMedical physicsNeuroradiologymedicine.diagnostic_testEquipment Safetybusiness.industryRadiation doseRadiation doseGeneral MedicineConventional coronary angiographymedicine.diseaseComputed tomography coronary angiography Conventional coronary angiography Coronary artery disease Radiation dose TrainingClinical realitySafety EquipmentbusinessSettore MED/36 - Diagnostica Per Immagini E RadioterapiaRadiologyTomography X-Ray ComputedLa Radiologia medica
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Computed tomography coronary angiography plaque burden in patients with suspected coronary artery disease.

2009

Purpose To determine the relationship between established cardiovascular risk factors, clinical presentation and the extent of coronary artery disease (CAD), as described with computed tomography coronary angiography. Material and methods In this cross-sectional study, we included 567 symptomatic individuals without a history of CAD who consecutively underwent 64-slice computed tomography coronary angiography for evaluation of suspected CAD. We analyzed the prevalence of CAD depending on sex, age, symptoms and risk factors. Results A total of 8542 segments were analyzed. No evidence of CAD was observed in 225 patients (40%), nonsignificant CAD in 221 patients (39%) and significant CAD (lumi…

MaleCoronary angiographymedicine.medical_specialtyMultivariate analysisComputed tomographyCADCoronary Artery DiseaseDiseaseCoronary AngiographyCoronary artery diseaseRisk FactorsInternal medicineEpidemiologymedicineHumansIn patientcardiovascular diseasesAgedmedicine.diagnostic_testbusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseplaque burdenCross-Sectional StudiesMultivariate AnalysisCardiologyFemaleTomography X-Ray ComputedCardiology and Cardiovascular Medicinebusiness
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