0000000000054175

AUTHOR

Martin B. Leon

showing 14 related works from this author

Coronary artery bypass graft versus percutaneous coronary intervention with drug-eluting stent implantation for diabetic patients with unprotected le…

2013

textabstractAims: Data regarding the impact on clinical outcomes of PCI with DES implantation vs. CABG to treat unprotected left main coronary artery (ULMCA) disease in diabetic patients are still insufficient. The present study evaluated the short-term and long-term results of percutaneous and surgical revascularisation in diabetic patients with ULMCA disease in a large population. Methods and results: A total of 826 diabetic patients with ULMCA stenosis who received DES (n=520) or underwent CABG (n=306) were selected and analysed from the DELTA registry. In-hospital MACCE was significantly higher in the CABG group, mainly driven by a higher incidence of MI. At four-year follow-up, freedom…

medicine.medical_specialtyPercutaneousmedicine.medical_treatmentMedizinCoronary Artery DiseasePercutaneous Coronary InterventionSDG 3 - Good Health and Well-beingInternal medicineDiabetes mellitusmedicineDiabetes MellitusHumanscardiovascular diseasesRegistriesCoronary Artery Bypassbusiness.industryPercutaneous coronary interventionDrug-Eluting Stentsmedicine.diseaseSurgeryStenosismedicine.anatomical_structuresurgical procedures operativeTreatment OutcomeDrug-eluting stentConcomitantConventional PCICardiologyCardiology and Cardiovascular MedicinebusinessArteryEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
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Long-term outcomes of percutaneous coronary interventions or coronary artery bypass grafting for left main coronary artery disease in octogenarians (…

2014

Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged 80 years were selected and analyzed in a large multinational regist…

Malemedicine.medical_treatmentMedizinCoronaryKaplan-Meier EstimateCoronary AngiographyCohort StudiesPostoperative Complications80 and overMyocardial infarctionHospital MortalityRegistriesSurvivorsAngioplasty Balloon CoronaryCoronary Artery BypassAged 80 and overEjection fractionHazard ratioAge FactorsAge Factors; Aged 80 and over; Angioplasty Balloon Coronary; Cohort Studies; Coronary Angiography; Coronary Artery Bypass; Coronary Stenosis; Coronary Vessels; Female; Geriatric Assessment; Hospital Mortality; Humans; Kaplan-Meier Estimate; Male; Percutaneous Coronary Intervention; Postoperative Complications; Prognosis; Propensity Score; Registries; Retrospective Studies; Risk Assessment; Survival Analysis; Survivors; Treatment Outcome; Drug-Eluting Stents; Cardiology and Cardiovascular MedicineDrug-Eluting StentsPrognosisCoronary Vesselssurgical procedures operativeTreatment OutcomeDrug-eluting stentCardiologyFemaleCardiology and Cardiovascular Medicinemedicine.medical_specialtyRevascularizationRisk AssessmentPercutaneous Coronary InterventionInternal medicineAngioplastymedicineHumanscardiovascular diseasesPropensity ScoreGeriatric AssessmentAgedRetrospective Studiesbusiness.industryAngioplastyCoronary StenosisPercutaneous coronary interventionmedicine.diseaseSurvival AnalysisSurgeryConventional PCIbusinessBalloon
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Drug eluting and bare metal stents in people with and without diabetes: Collaborative network meta-analysis

2008

Objective To compare the effectiveness and safety of three types of stents (sirolimus eluting, paclitaxel eluting, and bare metal) in people with and without diabetes mellitus. Design Collaborative network meta-analysis. Data sources Electronic databases (Medline, Embase, the Cochrane Central Register of Controlled Trials), relevant websites, reference lists, conference abstracts, reviews, book chapters, and proceedings of advisory panels for the US Food and Drug Administration. Manufacturers and trialists provided additional data. Review methods Network meta-analysis with a mixed treatment comparison method to combine direct within trial comparisons between stents with indirect evidence fr…

medicine.medical_specialtyPaclitaxelmedicine.medical_treatment030204 cardiovascular system & hematologyCoronary Restenosis03 medical and health scienceschemistry.chemical_compound0302 clinical medicineBlood vessel prosthesisInternal medicinemedicineHumans030212 general & internal medicinecardiovascular diseasesGeneral Environmental ScienceRandomized Controlled Trials as TopicSirolimusbusiness.industryResearchHazard ratioGeneral EngineeringDrug-Eluting StentsGeneral Medicineequipment and supplies3. Good healthSurgeryBlood Vessel ProsthesisProsthesis FailureClinical trialsurgical procedures operativePaclitaxelchemistryDrug-eluting stentMeta-analysisSirolimusGeneral Earth and Planetary SciencesPlatelet aggregation inhibitorStentsbusinessDiabetic AngiopathiesPlatelet Aggregation Inhibitorsmedicine.drug
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Predictive Factors, Management, and Clinical Outcomes of Coronary Obstruction Following Transcatheter Aortic Valve Implantation

2013

Objectives This study sought to evaluate the main baseline and procedural characteristics, management, and clinical outcomes of patients from a large cohort of patients undergoing transcatheter aortic valve implantation (TAVI) who suffered coronary obstruction (CO). Background Very little data exist on CO following TAVI. Methods This multicenter registry included 44 patients who suffered symptomatic CO following TAVI of 6,688 patients (0.66%). Pre-TAVI computed tomography data was available in 28 CO patients and in a control group of 345 patients (comparisons were performed including all patients and a cohort matched 1:1 by age, sex, previous coronary artery bypass graft, transcatheter valv…

medicine.medical_specialtyPercutaneous aortic valve replacementbusiness.industrymedicine.medical_treatmentPercutaneous coronary interventionSurgeryLeft coronary arteryCoronary occlusionRight coronary arterymedicine.arteryInternal medicineCohortmedicineCardiologyCardiology and Cardiovascular MedicinebusinessComplicationTIMIJournal of the American College of Cardiology
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Anatomical and procedural features associated with aortic root rupture during balloon-expandable transcatheter aortic valve replacement

2013

Background— Aortic root rupture is a major concern with balloon-expandable transcatheter aortic valve replacement (TAVR). We sought to identify predictors of aortic root rupture during balloon-expandable TAVR by using multidetector computed tomography. Methods and Results— Thirty-one consecutive patients who experienced left ventricular outflow tract (LVOT)/annular/aortic contained/noncontained rupture during TAVR were collected from 16 centers. A caliper-matched sample of 31 consecutive patients without annular rupture, who underwent pre-TAVR multidetector computed tomography served as a control group. Multidetector computed tomography assessment included short- and long-axis diameters an…

Malemedicine.medical_specialtyCardiac CatheterizationTranscatheter aorticAortic rootmedicine.medical_treatmentAortic Rupturemultidetector computed tomographySettore MED/11 - Malattie dell'Apparato CardiovascolareCohort StudiesValve replacementPredictive Value of TestsRisk FactorsPhysiology (medical)Internal medicineMultidetector computed tomographymedicine80 and overVentricular outflow tractHumanscardiovascular diseasesannular calcification; annular rupture; multidetector computed tomography; transcatheter heart valves; Aged; Aged 80 and over; Angioplasty Balloon; Aortic Rupture; Aortic Valve; Aortic Valve Stenosis; Calcinosis; Cohort Studies; Female; Heart Valve Prosthesis Implantation; Humans; Logistic Models; Male; Predictive Value of Tests; Risk Factors; Tomography X-Ray Computed; Cardiac CatheterizationTomographyAgedAged 80 and overHeart Valve Prosthesis Implantationbusiness.industrySinotubular JunctionAngioplastyCalcinosisAortic Valve Stenosismedicine.diseaseX-Ray ComputedBalloon expandable stentLogistic Modelstranscatheter heart valvesAortic ValveCardiologycardiovascular systemannular ruptureFemaleRadiologyCardiology and Cardiovascular MedicinebusinessTomography X-Ray ComputedAngioplasty BalloonBalloonCalcificationannular calcification
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058 THE ROLE OF FEMALE SEX IN THE CONTEMPORARY TREATMENT OF THE LEFT MAIN CORONARY ARTERY INSIGHTS FROM THE W-DELTA (WOMEN-DRUG ELUTING STENT FOR LEF…

2013

Background The optimal revascularization strategy of women with unprotected left main coronary artery (ULMCA) disease is unknown. Therefore, the aim of this study was to evaluate long-term clinical outcomes in this cohort treated with percutaneous coronary intervention (PCI) utilising drug-eluting stents (DES) versus coronary artery bypass grafting (CABG). Methods All consecutive women from the Drug Eluting stent for LefT main coronary Artery disease (DELTA) Registry with ULMCA disease treated by PCI with DES or CABG were analysed. A propensity matching was performed to adjust for baseline differences between the 2 treatment groups. Results In total, 818 women were included: 489 (59.8%) und…

medicine.medical_specialtyInterventional cardiologybusiness.industrymedicine.medical_treatmentPercutaneous coronary interventionRevascularizationmedicine.diseaseDrug-eluting stentInternal medicineConventional PCIPropensity score matchingCardiologymedicinecardiovascular diseasesMyocardial infarctionCardiology and Cardiovascular MedicinebusinessStrokeHeart
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Long-Term Clinical Outcomes After Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Ostial/Midshaft Lesions in Unprotecte…

2014

Objectives The aim of this study was to report the long-term clinical outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) versus coronary artery bypass grafting (CABG) for ostial/midshaft lesions in an unprotected left main coronary artery (ULMCA). Background Data regarding outcomes in these patients are limited. Methods Of a total of 2,775 patients enrolled in the DELTA multinational registry, 856 patients with isolated ostial/midshaft lesions in an ULMCA treated by PCI with DES (n = 482) or CABG (n = 374) were analyzed. Results At a median follow-up period of 1,293 days, there were no significant differences in the propensity score-adjusted analyses for …

medicine.medical_specialtybusiness.industryIncidence (epidemiology)medicine.medical_treatmentHazard ratioPercutaneous coronary interventionEuroSCOREmedicine.diseaseConfidence intervalSurgerymedicine.anatomical_structureInternal medicineConventional PCImedicineCardiologyMyocardial infarctionbusinessCardiology and Cardiovascular MedicineArteryJACC-Cardiovascular interventions
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Comparison of Percutaneous Coronary Intervention (With Drug-Eluting Stents) Versus Coronary Artery Bypass Grafting in Women With Severe Narrowing of …

2014

Women typically present with coronary artery disease later than men with more unfavorable clinical and anatomic characteristics. It is unknown whether differences exist in women undergoing treatment for unprotected left main coronary artery (ULMCA) disease. Our aim was to evaluate long-term clinical outcomes in women treated with percutaneous coronary intervention (PCI) with drug-eluting stents versus coronary artery bypass grafting (CABG). All consecutive women from the Drug-Eluting stent for LefT main coronary Artery disease registry with ULMCA disease were analyzed. A propensity matching was performed to adjust for baseline differences. In total, 817 women were included: 489 (59.8%) unde…

medicine.medical_specialtyTime Factorsmedicine.medical_treatmentCoronary AngiographySeverity of Illness IndexCoronary artery diseasePercutaneous Coronary InterventionRisk FactorsInternal medicinemedicineHumansMyocardial infarctionRegistriesCoronary Artery BypassPropensity ScoreAgedRetrospective Studiesbusiness.industryCoronary StenosisPercutaneous coronary interventionStentDrug-Eluting StentsOdds ratiomedicine.diseaseCoronary VesselsSurgerymedicine.anatomical_structureTreatment OutcomeDrug-eluting stentConventional PCICardiologyFemaleCardiology and Cardiovascular MedicinebusinessArteryFollow-Up Studies
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Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research.

2020

AbstractCoronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The suspected contribution of thrombotic events to morbidity and mortality in COVID-19 patients has prompted a search for novel potential options for preventing COVID-19-associated thrombotic disease. In this article by the Global COVID-19 Thrombosis Collaborative Group, we describe novel dosing approaches for commonly used antithrombotic agents (especially heparin-based regimens) and the potential use of less widely used antithrombotic drugs in the absence of confirmed thrombosis. Although these therapies may have direct…

0301 basic medicinecoronavirusAnti-Inflammatory AgentsReview Article030204 cardiovascular system & hematologymedicine.disease_causelaw.inventioncovid190302 clinical medicineRandomized controlled triallawAntithromboticPandemicViralanticoagulationCoronavirusGlycosaminoglycansAnimals; Anti-Inflammatory Agents; Anticoagulants; Antiviral Agents; Betacoronavirus; Coronavirus Infections; Fibrinolytic Agents; Glycosaminoglycans; Hemostasis; Humans; Inflammation; Pandemics; Platelet Aggregation Inhibitors; Pneumonia Viral; Thrombosiscoronavirus 2immunomodulatorHematologyHeparinThrombosisantithrombinCoronavirus Infectionsmedicine.drugmedicine.medical_specialtyPneumonia Viralcoronavirus disease 2019 thrombosis inflammation fibrinolytic therapy anticoagulation immunomodulator antithrombin thrombomodulinAntiviral Agents03 medical and health sciencescoronavirus disease 2019BetacoronavirusFibrinolytic AgentsmedicineAnimalsHumansthrombosis COVID-19 coronavirusDosingIntensive care medicinePandemicsthrombosisInflammationHemostasisbusiness.industrySARS-CoV-2AnticoagulantsCOVID-19ThrombosisPneumoniathrombomodulinmedicine.diseaseReview articleCOVID-19 Drug Treatment030104 developmental biologyinflammationfibrinolytic therapybusinessPlatelet Aggregation InhibitorsThrombosis and haemostasis
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Long-Term Clinical Outcomes After Percutaneous Coronary Intervention for Ostial/Mid-Shaft Lesions Versus Distal Bifurcation Lesions in Unprotected Le…

2013

Objectives The aim of this study was to compare, in a large all-comer registry, the long-term clinical outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) for ostial/mid-shaft lesions versus distal bifurcation lesions in unprotected left main coronary artery (ULMCA) stenosis. Background Limited data are available regarding clinical outcomes following DES implantation at the different ULMCA sites. Methods Patients with ULMCA stenosis treated by PCI with DES were analyzed in this multinational registry. Results A total of 1,612 patients were included: 482 were treated for ostial/mid-shaft lesions versus 1,130 for distal bifurcation lesions. At a median follo…

medicine.medical_specialtybusiness.industrymedicine.medical_treatmentPercutaneous coronary interventionmedicine.diseaseSurgeryStenosisDrug-eluting stentInterquartile rangeInternal medicineConventional PCICardiologymedicineMyocardial infarctionCardiology and Cardiovascular MedicinebusinessMaceIntra-aortic balloon pumpJACC: Cardiovascular Interventions
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Outcomes of transcatheter tricuspid valve intervention by right ventricular function: a multicentre propensity-matched analysis

2021

BACKGROUND Tricuspid regurgitation (TR) has a poor prognosis and limited treatment options and is frequently accompanied by right ventricular (RV) dysfunction. Transcatheter tricuspid valve interventions (TTVI) to reduce TR have been shown to be safe and feasible with encouraging early results. Patient selection for TTVI remains challenging, with the role of right ventricular (RV) function being unknown. AIMS The aims of this study were 1) to investigate survival in a TTVI-treated patient population and a conservatively treated TR population, and 2) to evaluate the outcome of TTVI as compared to conservative treatment stratified according to the degree of RV function. METHODS We studied 684…

medicine.medical_specialtyeducation.field_of_studyTricuspid valveVentricular functionbusiness.industryVentricular Dysfunction RightMortality rateHazard ratioPopulationTertiary careTricuspid Valve InsufficiencyTreatment Outcomemedicine.anatomical_structureInternal medicinePropensity score matchingCohortVentricular Function RightmedicineCardiologyHumansTricuspid ValveCardiology and Cardiovascular MedicineeducationbusinessEuroIntervention
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Drug-Eluting Stent for Left Main Coronary Artery Disease

2012

Objectives The aim of this study was to compare, in a large all-comers registry, major adverse cardiac and cerebrovascular events (MACCE) after percutaneous coronary intervention (PCI) with first-generation drug-eluting stents (DES) versus coronary artery bypass grafting (CABG) in unprotected left main coronary artery (ULMCA) stenosis. Background Percutaneous coronary intervention with DES implantation in ULMCA has been shown to be a feasible and safe approach at midterm clinical follow-up. Methods All consecutive patients with ULMCA stenosis treated by PCI with DES versus CABG were analyzed in this multinational registry. A propensity score analysis was performed to adjust for baseline dif…

medicine.medical_specialtybusiness.industrymedicine.medical_treatmentHazard ratioPercutaneous coronary interventionEuroSCOREmedicine.diseaseSurgeryCoronary artery diseasesurgical procedures operativeDrug-eluting stentAngioplastyInternal medicineConventional PCImedicineCardiologycardiovascular diseasesMyocardial infarctionbusinessCardiology and Cardiovascular MedicineJACC: Cardiovascular Interventions
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Computing Methods for Composite Clinical Endpoints in Unprotected Left Main Coronary Artery Revascularization

2016

Abstract Objectives The study sought to investigate the impact of different computing methods for composite endpoints other than time-to-event (TTE) statistics in a large, multicenter registry of unprotected left main coronary artery (ULMCA) disease. Background TTE statistics for composite outcome measures used in ULMCA studies consider only the first event, and all the contributory outcomes are handled as if of equal importance. Methods The TTE, Andersen-Gill, win ratio (WR), competing risk, and weighted composite endpoint (WCE) computing methods were applied to ULMCA patients revascularized by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) at 14 interna…

medicine.medical_specialtybusiness.industrymedicine.medical_treatmentPercutaneous coronary interventionInfarction030204 cardiovascular system & hematologymedicine.diseaseRevascularization03 medical and health sciences0302 clinical medicineInterquartile rangeInternal medicineConventional PCIPost-hoc analysismedicineClinical endpointCardiology030212 general & internal medicineMyocardial infarctionCardiology and Cardiovascular MedicinebusinessJACC: Cardiovascular Interventions
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Transfemoral Transcatheter Tricuspid Valve Replacement With the EVOQUE System

2021

Abstract Objectives The purpose of this observational first-in-human experience was to investigate the feasibility and safety of the EVOQUE tricuspid valve replacement system and its impact on short-term clinical outcomes. Background Transcatheter tricuspid intervention is a promising option for selected patients with severe tricuspid regurgitation (TR). Although transcatheter leaflet repair is an option for some, transcatheter tricuspid valve replacement (TTVR) may be applicable to a broader population. Methods Twenty-five patients with severe TR underwent EVOQUE TTVR in a compassionate-use experience. The primary outcome was technical success, with NYHA (NYHA) functional class, TR grade, …

medicine.medical_specialtyeducation.field_of_studyFramingham Risk Scorebusiness.industrymedicine.medical_treatmentPopulationTricuspid valve replacement030204 cardiovascular system & hematologySystem aSurgery03 medical and health sciences0302 clinical medicinecardiovascular systemEtiologyMedicineObservational studycardiovascular diseases030212 general & internal medicineCardiology and Cardiovascular MedicinebusinessProspective cohort studyeducationDialysisJACC: Cardiovascular Interventions
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