0000000000054177

AUTHOR

Yoshinobu Onuma

showing 9 related works from this author

Coronary artery bypass graft versus percutaneous coronary intervention with drug-eluting stent implantation for diabetic patients with unprotected le…

2013

textabstractAims: Data regarding the impact on clinical outcomes of PCI with DES implantation vs. CABG to treat unprotected left main coronary artery (ULMCA) disease in diabetic patients are still insufficient. The present study evaluated the short-term and long-term results of percutaneous and surgical revascularisation in diabetic patients with ULMCA disease in a large population. Methods and results: A total of 826 diabetic patients with ULMCA stenosis who received DES (n=520) or underwent CABG (n=306) were selected and analysed from the DELTA registry. In-hospital MACCE was significantly higher in the CABG group, mainly driven by a higher incidence of MI. At four-year follow-up, freedom…

medicine.medical_specialtyPercutaneousmedicine.medical_treatmentMedizinCoronary Artery DiseasePercutaneous Coronary InterventionSDG 3 - Good Health and Well-beingInternal medicineDiabetes mellitusmedicineDiabetes MellitusHumanscardiovascular diseasesRegistriesCoronary Artery Bypassbusiness.industryPercutaneous coronary interventionDrug-Eluting Stentsmedicine.diseaseSurgeryStenosismedicine.anatomical_structuresurgical procedures operativeTreatment OutcomeDrug-eluting stentConcomitantConventional PCICardiologyCardiology and Cardiovascular MedicinebusinessArteryEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
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Long-term outcomes of percutaneous coronary interventions or coronary artery bypass grafting for left main coronary artery disease in octogenarians (…

2014

Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged 80 years were selected and analyzed in a large multinational regist…

Malemedicine.medical_treatmentMedizinCoronaryKaplan-Meier EstimateCoronary AngiographyCohort StudiesPostoperative Complications80 and overMyocardial infarctionHospital MortalityRegistriesSurvivorsAngioplasty Balloon CoronaryCoronary Artery BypassAged 80 and overEjection fractionHazard ratioAge FactorsAge Factors; Aged 80 and over; Angioplasty Balloon Coronary; Cohort Studies; Coronary Angiography; Coronary Artery Bypass; Coronary Stenosis; Coronary Vessels; Female; Geriatric Assessment; Hospital Mortality; Humans; Kaplan-Meier Estimate; Male; Percutaneous Coronary Intervention; Postoperative Complications; Prognosis; Propensity Score; Registries; Retrospective Studies; Risk Assessment; Survival Analysis; Survivors; Treatment Outcome; Drug-Eluting Stents; Cardiology and Cardiovascular MedicineDrug-Eluting StentsPrognosisCoronary Vesselssurgical procedures operativeTreatment OutcomeDrug-eluting stentCardiologyFemaleCardiology and Cardiovascular Medicinemedicine.medical_specialtyRevascularizationRisk AssessmentPercutaneous Coronary InterventionInternal medicineAngioplastymedicineHumanscardiovascular diseasesPropensity ScoreGeriatric AssessmentAgedRetrospective Studiesbusiness.industryAngioplastyCoronary StenosisPercutaneous coronary interventionmedicine.diseaseSurvival AnalysisSurgeryConventional PCIbusinessBalloon
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Absorb Bioresorbable Scaffold Versus Xience Metallic Stent for Prevention of Restenosis Following Percutaneous Coronary Intervention in Patients at H…

2019

Abstract Background The advent of bioresorbable vascular scaffolds (BVS) was considered as a potential improvement in percutaneous coronary intervention (PCI) after the groundbreaking development of drug eluting stents (DES). However, the clinical performance, long-term safety and efficacy of BVS in complex coronary lesions remain uncertain. COMPARE ABSORB, a multicenter, single blind, prospective randomized trial, aims to compare the clinical outcomes between the Absorb BVS and Xience everolimus-eluting metallic stent (EES) in patients with coronary artery disease and a high risk of restenosis. Design COMPARE ABSORB is designed to enroll 2100 patients at up to 45 European sites. Enrolled p…

MaleBioresorbable scaffoldTime Factorsmedicine.medical_treatmentVascular damage Radboud Institute for Health Sciences [Radboudumc 16]030204 cardiovascular system & hematologyAbsorbCoronary artery diseaseCoronary artery disease0302 clinical medicineRestenosisRisk FactorsAbsorbable ImplantsClinical endpointMulticenter Studies as TopicMedicineSingle-Blind MethodProspective Studies030212 general & internal medicineMyocardial infarctionAngioplasty Balloon CoronaryGeneral MedicineMiddle AgedEuropeTreatment OutcomeMetalsCardiologyFemaleStentsCardiology and Cardiovascular MedicineAdultmedicine.medical_specialtyAdolescentProsthesis DesignRisk AssessmentCoronary RestenosisYoung Adult03 medical and health sciencesAll institutes and research themes of the Radboud University Medical CenterInternal medicineHumansAgedbusiness.industryStentPercutaneous coronary interventionCoronary Lesion ComplexityProtective Factorsmedicine.diseaseConventional PCIbusiness
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Long-Term Clinical Outcomes After Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Ostial/Midshaft Lesions in Unprotecte…

2014

Objectives The aim of this study was to report the long-term clinical outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) versus coronary artery bypass grafting (CABG) for ostial/midshaft lesions in an unprotected left main coronary artery (ULMCA). Background Data regarding outcomes in these patients are limited. Methods Of a total of 2,775 patients enrolled in the DELTA multinational registry, 856 patients with isolated ostial/midshaft lesions in an ULMCA treated by PCI with DES (n = 482) or CABG (n = 374) were analyzed. Results At a median follow-up period of 1,293 days, there were no significant differences in the propensity score-adjusted analyses for …

medicine.medical_specialtybusiness.industryIncidence (epidemiology)medicine.medical_treatmentHazard ratioPercutaneous coronary interventionEuroSCOREmedicine.diseaseConfidence intervalSurgerymedicine.anatomical_structureInternal medicineConventional PCImedicineCardiologyMyocardial infarctionbusinessCardiology and Cardiovascular MedicineArteryJACC-Cardiovascular interventions
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Comparison of Percutaneous Coronary Intervention (With Drug-Eluting Stents) Versus Coronary Artery Bypass Grafting in Women With Severe Narrowing of …

2014

Women typically present with coronary artery disease later than men with more unfavorable clinical and anatomic characteristics. It is unknown whether differences exist in women undergoing treatment for unprotected left main coronary artery (ULMCA) disease. Our aim was to evaluate long-term clinical outcomes in women treated with percutaneous coronary intervention (PCI) with drug-eluting stents versus coronary artery bypass grafting (CABG). All consecutive women from the Drug-Eluting stent for LefT main coronary Artery disease registry with ULMCA disease were analyzed. A propensity matching was performed to adjust for baseline differences. In total, 817 women were included: 489 (59.8%) unde…

medicine.medical_specialtyTime Factorsmedicine.medical_treatmentCoronary AngiographySeverity of Illness IndexCoronary artery diseasePercutaneous Coronary InterventionRisk FactorsInternal medicinemedicineHumansMyocardial infarctionRegistriesCoronary Artery BypassPropensity ScoreAgedRetrospective Studiesbusiness.industryCoronary StenosisPercutaneous coronary interventionStentDrug-Eluting StentsOdds ratiomedicine.diseaseCoronary VesselsSurgerymedicine.anatomical_structureTreatment OutcomeDrug-eluting stentConventional PCICardiologyFemaleCardiology and Cardiovascular MedicinebusinessArteryFollow-Up Studies
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Long-Term Clinical Outcomes After Percutaneous Coronary Intervention for Ostial/Mid-Shaft Lesions Versus Distal Bifurcation Lesions in Unprotected Le…

2013

Objectives The aim of this study was to compare, in a large all-comer registry, the long-term clinical outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) for ostial/mid-shaft lesions versus distal bifurcation lesions in unprotected left main coronary artery (ULMCA) stenosis. Background Limited data are available regarding clinical outcomes following DES implantation at the different ULMCA sites. Methods Patients with ULMCA stenosis treated by PCI with DES were analyzed in this multinational registry. Results A total of 1,612 patients were included: 482 were treated for ostial/mid-shaft lesions versus 1,130 for distal bifurcation lesions. At a median follo…

medicine.medical_specialtybusiness.industrymedicine.medical_treatmentPercutaneous coronary interventionmedicine.diseaseSurgeryStenosisDrug-eluting stentInterquartile rangeInternal medicineConventional PCICardiologymedicineMyocardial infarctionCardiology and Cardiovascular MedicinebusinessMaceIntra-aortic balloon pumpJACC: Cardiovascular Interventions
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Drug-Eluting Stent for Left Main Coronary Artery Disease

2012

Objectives The aim of this study was to compare, in a large all-comers registry, major adverse cardiac and cerebrovascular events (MACCE) after percutaneous coronary intervention (PCI) with first-generation drug-eluting stents (DES) versus coronary artery bypass grafting (CABG) in unprotected left main coronary artery (ULMCA) stenosis. Background Percutaneous coronary intervention with DES implantation in ULMCA has been shown to be a feasible and safe approach at midterm clinical follow-up. Methods All consecutive patients with ULMCA stenosis treated by PCI with DES versus CABG were analyzed in this multinational registry. A propensity score analysis was performed to adjust for baseline dif…

medicine.medical_specialtybusiness.industrymedicine.medical_treatmentHazard ratioPercutaneous coronary interventionEuroSCOREmedicine.diseaseSurgeryCoronary artery diseasesurgical procedures operativeDrug-eluting stentAngioplastyInternal medicineConventional PCImedicineCardiologycardiovascular diseasesMyocardial infarctionbusinessCardiology and Cardiovascular MedicineJACC: Cardiovascular Interventions
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Computing Methods for Composite Clinical Endpoints in Unprotected Left Main Coronary Artery Revascularization

2016

Abstract Objectives The study sought to investigate the impact of different computing methods for composite endpoints other than time-to-event (TTE) statistics in a large, multicenter registry of unprotected left main coronary artery (ULMCA) disease. Background TTE statistics for composite outcome measures used in ULMCA studies consider only the first event, and all the contributory outcomes are handled as if of equal importance. Methods The TTE, Andersen-Gill, win ratio (WR), competing risk, and weighted composite endpoint (WCE) computing methods were applied to ULMCA patients revascularized by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) at 14 interna…

medicine.medical_specialtybusiness.industrymedicine.medical_treatmentPercutaneous coronary interventionInfarction030204 cardiovascular system & hematologymedicine.diseaseRevascularization03 medical and health sciences0302 clinical medicineInterquartile rangeInternal medicineConventional PCIPost-hoc analysismedicineClinical endpointCardiology030212 general & internal medicineMyocardial infarctionCardiology and Cardiovascular MedicinebusinessJACC: Cardiovascular Interventions
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Long-term clinical outcomes after percutaneous coronary intervention versus coronary artery bypass grafting for acute coronary syndrome from the DELT…

2016

AIMS Our aim was to compare, in a large unprotected left main coronary artery (ULMCA) all-comer registry, the long-term clinical outcome after percutaneous coronary intervention (PCI) with first-generation drug-eluting stents (DES) versus coronary artery bypass grafting (CABG) in patients with acute coronary syndrome (ACS). METHODS AND RESULTS Of a total of 2,775 patients enrolled in the Drug Eluting Stents for Left Main Coronary Artery Disease (DELTA) multicentre registry, 379 (13.7%) patients with ACS treated with PCI (n=272) or CABG (n=107) were analysed. Baseline demographics were considerably different in the two groups before propensity matching. No significant differences emerged for…

AdultMalemedicine.medical_specialtyAcute coronary syndromemedicine.medical_treatmentMyocardial Infarction030204 cardiovascular system & hematology03 medical and health sciencesPercutaneous Coronary Intervention0302 clinical medicineInternal medicineHumansMedicineRegistriescardiovascular diseases030212 general & internal medicineMyocardial infarctionAcute Coronary SyndromeCoronary Artery BypassStrokeAgedAged 80 and overbusiness.industryIncidence (epidemiology)Coronary StenosisPercutaneous coronary interventionDrug-Eluting StentsMiddle Agedmedicine.diseaseSurgeryStrokeTreatment Outcomemedicine.anatomical_structurePropensity score matchingConventional PCICardiologyFemaleCardiology and Cardiovascular MedicinebusinessArteryEuroIntervention
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