THE METABOLIC SYNDROME: IL-10 POLYMORPHISMS INFLUENCE ON SEROLOGICAL AND HAEMATOLOGICAL PARAMETERS IN TYPE 2 DIABETES.

Genetic Background of Centenarians May Be Protective Against Cardiovascular Diseases.

Polymorphisms of pro-inflammatory genes and Alzheimer's disease risk.

Role of polymorphisms of CC-chemokine receptor-5 (CCR5) gene in acute myocardial infarction and biological implications for longevity.

Opposite role of CCR5 polymorphisms in cardiovascular diseases and longevity.

Study of the Association with -330T/G IL-2 in a Population of Centenarians from Centre and South Italy.

Immune response in elderly is characterised by a progressive loss of the ability to cope environmental stressors with a characteristic remodelling of cytokine network. One of the data constantly reported in literature is the decrease of IL-2 production. An IL-2 central role in the reconstitution of T cell function in vitro is largely documented. Studies on a T → G polymorphism at - 330 nt of IL-2 gene promoter region have demonstrated that T lymphocytes from 330GG homozygous subjects are able to produce in vitro higher amount of IL-2, than -330TG heterozygous or -330TT homozygous subjects. As a genetic background conditioning the maintaining of an efficient immune response would exert posit…

Analysis of common functional paraoxonase polymorphism Leu-Met (55) in the Sardinian population.

PROTECTIVE DETERMINANTS AGAINST CARDIOVASCULAR DISEASES ARE PRESENT IN GENETIC BACKGROUND OF CENTENARIANS.

Longevity in: Cytokine Gene Polymorphisms in multifactorial conditions. (K. Vandenbroeck ed.)

Frequenze degli aplotipi-1082GA/819CT/592CA della regione promoter del locus IL-10 in campioni di DNA ottenuti da pazienti affetti da Diabete mellito di tipo II.

Mitochondrial haplogroups in a Sardinian centenarian population.

The role of three polymorphisms in the promoter of interleukin 6 in the ageing processes.

FREQUENZA DEGLI ALLELI DEL POLIMORFISMO -330T-->G IL-2 IN UNA POPOLAZIONE DI CENTENARI ITALIANI

Genetics, gender and longevity

PROTECTIVE DETERMINANTS AGAINST CARDIOVASCULAR DISEASES ARE PRESENT IN GENETIC BACKGROUND OF CENTENARIANS

IL-2 HIGH PRODUCER GENETIC BACKGROUND IS NEGATIVELY ASSOCIATED TO LONGEVITY

OPPOSITE ROLE OF TRL4 RECEPTOR IN ACUTE MYOCARDIAL INFARCTION AND LONGEVITY

RUOLO DELLA CITOCHINA PRO-INFIAMMATORIA TNF NELL’INVECCHIAMENTO SENZA SUCCESSO E NELLA LONGEVITÀ

GENETIC BACKGROUND OF CENTENARIANS MAY BE PROTECTIVE AGAINST CARDIOVASCULAR DISEASES

LONGEVITY AND MYOCARDIAL INFARCTION: ROLE OF ALPHA1-ANTITRYPSIN DEFICENCY

Analisi della frequenza del polimorfismo -330T/G della regione promoter del gene IL-2 in una coorte di centenari italiani

RUOLO DEL GENOTIPO DELL’ALFA1-ANTITRIPSINA NEL RAGGIUNGIMENTO DELL’INVECCHIAMENTO CON SUCCESSO

Ruolo del recettore TLR4 nella febbre bottonosa e nella longevità

NACHR4 594C/T SNP IN ALZHEIMER’S DISEASE