0000000000057570
AUTHOR
Franceschi C
showing 24 related works from this author
THE METABOLIC SYNDROME: IL-10 POLYMORPHISMS INFLUENCE ON SEROLOGICAL AND HAEMATOLOGICAL PARAMETERS IN TYPE 2 DIABETES.
2007
Genetic Background of Centenarians May Be Protective Against Cardiovascular Diseases.
2004
Polymorphisms of pro-inflammatory genes and Alzheimer's disease risk.
2006
Role of polymorphisms of CC-chemokine receptor-5 (CCR5) gene in acute myocardial infarction and biological implications for longevity.
2008
Opposite role of CCR5 polymorphisms in cardiovascular diseases and longevity.
2005
Study of the Association with -330T/G IL-2 in a Population of Centenarians from Centre and South Italy.
2005
Immune response in elderly is characterised by a progressive loss of the ability to cope environmental stressors with a characteristic remodelling of cytokine network. One of the data constantly reported in literature is the decrease of IL-2 production. An IL-2 central role in the reconstitution of T cell function in vitro is largely documented. Studies on a T → G polymorphism at - 330 nt of IL-2 gene promoter region have demonstrated that T lymphocytes from 330GG homozygous subjects are able to produce in vitro higher amount of IL-2, than -330TG heterozygous or -330TT homozygous subjects. As a genetic background conditioning the maintaining of an efficient immune response would exert posit…