0000000000061971

AUTHOR

M.f. Pinnert

showing 6 related works from this author

Comparison of the chemopreventive efficacies of garlic powders with different alliin contents against aflatoxin B1 carcinogenicity in rats

2004

Garlic (Allium sativum) is well known for its beneficial effects on health and particularly for its chemopreventive potential against cancer. The present study was designed to compare the chemopreventive efficacies of several garlic powders with various levels of alliin, a precursor of active sulfur compounds. For this purpose we used the medium-term hepatocarcinogenesis protocol (resistant hepatocyte model), which allows the detection of preneoplasic foci expressing the placental form of glutathione S-transferase (GST-P) as an end-point. Rats were fed diets containing three garlic powders (5% of the diet) with various alliin contents for 3 weeks. Garlic powders were obtained from bulbs gro…

GARLIC POWDERMale[SDE] Environmental SciencesCancer ResearchAflatoxinAflatoxin B1[SDV]Life Sciences [q-bio]Antineoplastic AgentsAlliinChemoprevention03 medical and health scienceschemistry.chemical_compound0302 clinical medicinefoodLiver Neoplasms ExperimentalCytochrome P-450 CYP1A1IngestionAnimalsFood scienceCysteineGlucuronosyltransferaseRats WistarGarlicAnticarcinogenCarcinogenComputingMilieux_MISCELLANEOUS030304 developmental biologyGlutathione Transferase2. Zero hunger0303 health sciencesfood and beveragesGeneral MedicineGlutathioneAllium sativumCANCERfood.food3. Good healthDietRats[SDV] Life Sciences [q-bio]chemistryBiochemistry030220 oncology & carcinogenesis[SDE]Environmental SciencesRATPowdersCARCINOGENESEPrecancerous Conditions
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Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis

2004

Effects of administration of diallyl sulfide (DAS) and diallyl disulfide (DADS) on the promotion stage of hepatocarcinogenesis were investigated in rats using the Ito model. They were compared with those of phenobarbital (PB), a well-known liver promoter in rats. Initiation was induced by a single dose of N-nitrosodiethylamine (NDEA) and 3 weeks later, a partial hepatectomy was conducted. Two weeks after the NDEA injection, rats received either 0.05% allyl sulfides, PB or both in their diet for 8 weeks. Feeding with DAS increased the number of liver preneoplastic foci by 63% with respect to the untreated group. However, rats fed DAS showed a lower foci development than rats fed PB. The DADS…

Malemedicine.medical_treatment[SDV]Life Sciences [q-bio]Toxicologymedicine.disease_causechemistry.chemical_compound0302 clinical medicineLiver Neoplasms ExperimentalDiethylnitrosamineDrug InteractionsDisulfidesComputingMilieux_MISCELLANEOUS0303 health sciencesDiallyl disulfideGeneral MedicineCANCER3. Good healthSpecific Pathogen-Free OrganismsAllyl Compounds[SDV] Life Sciences [q-bio]BiochemistryDiallyl sulfide030220 oncology & carcinogenesismedicine.drugmedicine.medical_specialtySulfidesDIALLYL DISULFITEChemopreventionPreneoplastic foci03 medical and health sciencesInternal medicinemedicineAnimalsAnticarcinogenic AgentsHepatectomyDIALLYL SULFITERats Wistar030304 developmental biologyRatsEndocrinologychemistryRat liverCarcinogensRATPhenobarbitalHepatectomyCarcinogenesisAllyl SulfidePrecancerous ConditionsFood Science
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Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats : a comparative study

2003

International audience; The objective of this study was to compare the estrogenicity of xenoestrogens found in food wrap packaging and phytoestrogen flavonoids. Uterotrophic and vaginal cornification assays were performed on immature and ovariectomized rats. Genistein, bisphenol F, and octylphenol were identified as estrogenic only in immature rats. Using vaginal cornification as a more specific estrogenic parameter, all tested compounds except tangeretin were active in immature rats. While apigenin and kaempferol appeared to have low estrogenic activity, they potentialized the uterotrophic effect of 17β-estradiol in immature rats. These data showed that (i) phytoestrogens like genistein ca…

Genistein010501 environmental sciencesToxicology01 natural scienceschemistry.chemical_compound[SDV.IDA]Life Sciences [q-bio]/Food engineering0303 health sciencesIMMATURE RATSEstradiolMolecular Structurefood and beveragesOrgan SizePHYTOESTROGENS[SDV.IDA] Life Sciences [q-bio]/Food engineeringVAGINAL CORNIFICATIONVaginaApigeninToxicityOvariectomized ratFemalehormones hormone substitutes and hormone antagonistsmedicine.medical_specialtymedicine.drug_class[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process EngineeringOvariectomyXENOESTROGENSBiologySensitivity and Specificity03 medical and health sciencesPredictive Value of TestsIn vivoInternal medicinemedicineAnimals[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process EngineeringEstrogens Non-SteroidalRats Wistar030304 developmental biology0105 earth and related environmental sciencesFlavonoidsDose-Response Relationship DrugOVARIECTOMIZED RATSUterusEstrogensUTEROTROPHIC ASSAYIsoflavonesRatsEndocrinologychemistryEstrogenPhytoestrogensPlant PreparationsKaempferol
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Chemoprevention of hepatocarcinogenesis in rats by diallyl disulphide and dipropyl sulphide : dose-response effect

1999

International audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]RATCANCERComputingMilieux_MISCELLANEOUS
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Propriétés anticancérogènes de deux composés issus des alliacées : le disulfure de diallyle et le sulfure de dipropyle

1998

*INRA Centre de Dijon (FRA) Diffusion du document : INRA Centre de Dijon (FRA); National audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]
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Modèles d'hépatocancérogenèse chez le rat : application à l'étude de la prévention du cancer par la consommation de produits végétaux

2001

National audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]RATComputingMilieux_MISCELLANEOUS
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