0000000000064336

AUTHOR

Massimiliano Papi

showing 2 related works from this author

IRIDE: Interdisciplinary research infrastructure based on dual electron linacs and lasers

2014

This paper describes the scientific aims and potentials as well as the preliminary technical design of RUDE, an innovative tool for multi-disciplinary investigations in a wide field of scientific, technological and industrial applications. IRIDE will be a high intensity "particles factory", based on a combination of high duty cycle radio-frequency superconducting electron linacs and of high energy lasers. Conceived to provide unique research possibilities for particle physics, for condensed matter physics, chemistry and material science, for structural biology and industrial applications, IRIDE will open completely new research possibilities and advance our knowledge in many branches of sci…

Nuclear and High Energy PhysicsHigh energySC Linac;Neutron source;FEL;Compton source;Advanced accelerators concepts;Particle physicsSettore FIS/07 - FISICA APPLICATA (A BENI CULTURALI AMBIENTALI BIOLOGIA E MEDICINA)Advanced accelerators conceptTechnical designNOAdvanced accelerators conceptsParticle physicSC Linac; FEL; Particle physics; Neutron source; Compton source; Advanced accelerators conceptsInstrumentationFELPhysicsSC LinacSettore FIS/01 - Fisica SperimentaleAdvanced accelerators concepts; Compton source; FEL; Neutron source; Particle physics; SC Linac; Instrumentation; Nuclear and High Energy PhysicsParticle physicsAdvanced accelerators concepts; Compton source; FEL; Neutron source; Particle physics; SC Linac; Nuclear and High Energy Physics; InstrumentationCompton sourceNeutron sourceWide fieldSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)Dual (category theory)Free Electron LaserAdvanced accelerators concepts Compton source FEL Neutron source Particle physics SC LinacAdvanced accelerators concepts; Compton source; FEL; Neutron source; Particle physics; SC Linacadvanced accelerators concepts; particle physics; sc linac; compton source; fel; neutron sourceneutron sourcefree electron lasersSystems engineeringFactory (object-oriented programming)Free electron laser
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Janus -faced liposomes enhance antimicrobial innate immune response in Mycobacterium tuberculosis infection

2012

We have generated unique asymmetric liposomes with phosphatidylserine (PS) distributed at the outer membrane surface to resemble apoptotic bodies and phosphatidic acid (PA) at the inner layer as a strategy to enhance innate antimycobacterial activity in phagocytes while limiting the inflammatory response. Results show that these apoptotic body-like liposomes carrying PA (ABL/PA) ( i ) are more efficiently internalized by human macrophages than by nonprofessional phagocytes, ( ii ) induce cytosolic Ca 2+ influx, ( iii ) promote Ca 2+ -dependent maturation of phagolysosomes containing Mycobacterium tuberculosis (MTB), ( iv ) induce Ca 2+ -dependent reactive oxygen species (ROS) production, (…

MaleAntitubercular AgentsApoptosisSettore MED/07Mice0302 clinical medicineInnateInbred BALB CMycobacterium tuberculosis liposomes0303 health sciencesMice Inbred BALB CMultidisciplinaryLeukemiaTumorbiologyMacrophages; Leukemia Monocytic Acute; Animals; Apoptosis; Calcium; Humans; Disease Models Animal; Mice; Cell Line Tumor; Immunity Innate; Reactive Oxygen Species; Mice Inbred BALB C; Liposomes; Phosphatidylserines; Tuberculosis Pulmonary; Adult; Bronchoalveolar Lavage Fluid; Middle Aged; Antitubercular Agents; Phagocytosis; Male; Mycobacterium tuberculosis; IsoniazidInterleukinPulmonaryMiddle AgedSettore BIO/193. Good healthPNAS PlusLeukemia Monocytic AcuteTumor necrosis factor alphaBronchoalveolar Lavage FluidIntracellularAdultPhagocytosisPhosphatidylserinesAcutePhagolysosomeSettore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICAMicrobiologyCell LineMycobacterium tuberculosis03 medical and health sciencesPhagocytosisCell Line TumorIsoniazidTuberculosisAnimalsHumansTuberculosis Pulmonary030304 developmental biologySettore MED/04 - Patologia GeneraletherapyInnate immune systemMonocyticAnimalMacrophagesImmunityMycobacterium tuberculosisbiology.organism_classificationImmunity InnateDisease Models AnimalApoptosisImmunologyDisease ModelsLiposomesCalciumReactive Oxygen Species030215 immunology
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