0000000000064548

AUTHOR

Mireia Moreno-estellés

showing 2 related works from this author

Neural stem cells in the adult olfactory bulb core generate mature neurons in vivo.

2021

17 páginas, 7 figuras.

0301 basic medicineNeurobiologia del desenvolupamentRostral migratory streamNeurogenesisSubventricular zoneStem cellsAdult neurogenesis03 medical and health sciencesMiceOlfactory bulb0302 clinical medicineCalretininNeural Stem CellsInterneuronsmedicineAnimalsDevelopmental neurobiologyNeural stem cellsNeuronsbiologyNeurogenesisCell DifferentiationCell BiologyOlfactory BulbNeural stem cellDoublecortinCell biologyOlfactory bulb030104 developmental biologymedicine.anatomical_structurenervous systemSynapsesbiology.proteinMolecular MedicineNeuronNeuNCèl·lules mare030217 neurology & neurosurgeryDevelopmental BiologyStem cells (Dayton, Ohio)REFERENCES
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Symmetric expansion of neural stem cells from the adult olfactory bulb is driven by astrocytes via WNT7A.

2012

Adult neural stem cells (NSCs) located in the subventricular zone (SVZ) persistently produce new neurons destined to the olfactory bulb (OB). Recent research suggests that the OB is also a source of NSCs that remains largely unexplored. Using single/dual-labeling procedures, we address the existence of NSCs in the innermost layers of the OB. In vivo, these cells are more quiescent that their SVZ counterparts, but after in vitro expansion, they behave similarly. Self-renewal and proliferation assays in co-culture with niche astrocytes indicate that OB-glia restricts NSC activity whereas SVZ-glia has the opposite effect. Gene expression profiling identifies WNT7A as a key SVZ-glial factor lac…

Cellular differentiationSubventricular zoneCell Growth ProcessesBiologyMiceNeural Stem CellsIn vivomedicineAnimalsHumansreproductive and urinary physiologyWnt signaling pathwayCell DifferentiationCell BiologyAnatomyOlfactory BulbNeural stem cellnervous system diseasesOlfactory bulbCell biologyGene expression profilingWnt ProteinsWNT7Amedicine.anatomical_structurenervous systemAstrocytesMolecular Medicinebiological phenomena cell phenomena and immunityDevelopmental BiologyStem cells (Dayton, Ohio)
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