0000000000067412

AUTHOR

Immanuels Taivāns

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Lipoxygenase-derived arachidonic acid metabolites in chronic obstructive pulmonary disease

2011

Background and Objective. Chronic obstructive pulmonary disease (COPD) is characterized by a persistence of inflammation in large and small airways. We hypothesized that this could be caused by the inability of an inflammatory process to resolve. In the resolution of inflammation, a switching of arachidonic acid metabolism from the production of proinflammatory leukotriene B4 (LtB4) to the synthesis of anti-inflammatory lipoxins plays an important role. The aim of our study was to determine the content of lipoxin A4 (LXA4) and LtB4 in induced sputum of patients with exacerbated COPD and to compare it to healthy controls, as well as to analyze the relationship between proinflammatory and ant…

MaleSputum CytologyExacerbationLeukotriene B4InflammationLeukotriene B4Proinflammatory cytokinePulmonary Disease Chronic Obstructivechemistry.chemical_compoundHumansMedicineCOPDbusiness.industrySputumGeneral MedicineMiddle Agedmedicine.diseaserespiratory tract diseasesLipoxinschemistrychronic obstructive pulmonary disease; exacerbation; lipoxin A<sub>4</sub>; leukotriene B<sub>4</sub>ImmunologyAbsolute neutrophil countSputumFemalelipids (amino acids peptides and proteins)medicine.symptombusiness
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