0000000000069055

AUTHOR

Lucia Babini

showing 2 related works from this author

Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-223 expressions : a study on postmenopausal mo…

2014

MiRNAs are fine-tuning modifiers of skeletal muscle regulation, but knowledge of their hormonal control is lacking. We used a co-twin case-control study design, that is, monozygotic postmenopausal twin pairs discordant for estrogen-based hormone replacement therapy (HRT) to explore estrogen-dependent skeletal muscle regulation via miRNAs. MiRNA profiles were determined from vastus lateralis muscle of nine healthy 54-62-years-old monozygotic female twin pairs discordant for HRT (median 7 years). MCF-7 cells, human myoblast cultures and mouse muscle experiments were used to confirm estrogen's causal role on the expression of specific miRNAs, their target mRNAs and proteins and finally the act…

MaleMICRORNASMonozygotic twinmenopausePATHWAYMice0302 clinical medicineMyocyteInsulin-Like Growth Factor IIN-VIVO0303 health sciencesphosphorylationAge FactorsBREAST-CANCER CELLSWOMENMiddle Aged3142 Public health care science environmental and occupational healthPostmenopauseESTROGENmedicine.anatomical_structureMCF-7 CellsmTORGROWTHFemaleAUTOPHAGYMESSENGER-RNASignal TransductionIGF-1 receptormedicine.medical_specialtyHormone Replacement Therapymedicine.drug_classmiR-142-3pBiology03 medical and health sciencesInternal medicinemicroRNAmedicineAnimalsHumansMuscle SkeletalProtein kinase BPI3K/AKT/mTOR pathwayAged030304 developmental biologyAKTagingSkeletal muscleOriginal ArticlesTwins MonozygoticCell BiologyAKT; FOXO3A; IGF-1 signaling; IGF-1R; aging; mTOR; menopause; miR-142-3p; miR-182; miR-223; phosphorylationmiR-223EndocrinologyEstrogenCase-Control StudiesmiR-1823121 General medicine internal medicine and other clinical medicineFOXO3AIGF-1 signalingIGF-1R030217 neurology & neurosurgeryHUMAN LONGEVITYHormone
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Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-233 expressions: A study on postmenopausal mon…

2014

MiRNAs are fine-tuning modifiers of skeletal muscle regulation, but knowledge of their hormonal control is lacking. We used a co-twin case–control study design, that is, monozygotic postmenopausal twin pairs discordant for estrogen-based hormone replacement therapy (HRT) to explore estrogen-dependent skeletal muscle regulation via miRNAs. MiRNA profiles were determined from vastus lateralis muscle of nine healthy 54–62- years-old monozygotic female twin pairs discordant for HRT (median 7 years). MCF-7 cells, human myoblast cultures and mouse muscle experiments were used to confirm estrogen’s causal role on the expression of specific miRNAs, their target mRNAs and proteins and finally the ac…

fosforylaatiovaihdevuodetAKTmiR-182agingmiR-142-3pmTORFOXO3AmiR-233IGF-1 signalingIGF-1R
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