0000000000069682
AUTHOR
J. Hammer
Hepatitis B surface antigen presentation and HLA-DRB1*– lessons from twins and peptide binding studies
Summary The aim of this study was to investigate the underlying mechanisms of the genetic association between certain HLA-DRB1* alleles and the immune response to HBsAg vaccination. Therefore, HBsAg peptide binding to HLA-DR molecules was measured in vitro by peptide binding ELISAs. Additionally, HBsAg-specific T cell reaction and cytokine profile of immune response were analysed ex vivo in ELISPOT assays and DR-restriction of T-cell proliferative responses was investigated with HBsAg specific T cell clones. In addition, we compared HBsAg specific T cell responses of 24 monozygotic and 3 dizygotic twin pairs after HBsAg vaccination. Our results showed that the peptide binding assays did not…
Geochronology and Nd-Sr systematics of Lusatian granitoids: significance for the evolution of the Variscan orogen in east-central Europe
A variety of pre-Variscan granitoids and two Variscan monzogranites occurring in the central and western parts of the Lusatian Granodiorite Complex (LGC), Saxonia were dated by the single zircon evaporation method, complemented by whole rock Nd isotopic data and Rb —Sr whole rock and mineral ages. The virtually undeformed pre-Variscan granitoids constitute a genetically related, mostly peraluminous magmatic suite, ranging in composition from two-mica granodiorite, muscovite-bearing biotite quartz diorite (tonalite) and granodiorite to biotite granodiorite and monozogranite.
Measurement of thett¯production cross section inpp¯collisions ats=1.96 TeVusing soft electronb-tagging
The authors present a measurement of the t{bar t} production cross section using events with one charged lepton and jets from p{bar p} collisions at a center-of-mass energy of 1.96 TeV. A b-tagging algorithm based on the probability of displaced tracks coming from the event interaction vertex is applied to identify b quarks from top decay. Using 318 pb{sup -1} of data collected with the CDF II detector, they measure the t{bar t} production cross section in events with at least one restrictive (tight) b-tagged jet and obtain 8.9{sub -1.0}{sup +1.0}(stat.){sub -1.0}{sup +1.1}(syst.) pb. The cross section value assumes a top quark mass of m{sub t} is presented in the paper. This result is cons…