0000000000070410
AUTHOR
Gagliano M
Chronic prenatal treatment with 5-methoxytryptamine reduced depressive-like behaviour induced by forced swim test in mature male rats
Perinatal treatment with 5-methoxytriptamine affects cognition and behavioural reactivity in the juvenile male rat progeny: influence of maternal separation
Repeated and single prenatal stress differently affect stress reactivity and learning performance in adolescent male rats
The role of histamine in doxorubicin and teniposide-induced cardiotoxicity in dog and mouse.
In previous studies we reported that teniposide (VM26) induced acute cardiac effects in dogs seem to be related to a release of histamine and that a prior treatment with chlorpheniramine, an H, histamine blocker, prevents the onset of this phenomenon. Since histamine and other vasoactive substances also seem to be involved in doxorubicin (DXR)-induced acute cardiac effects, experiments were undertaken in the aim to prevent, as in the case of VM26, the onset of this phenomenon by administering chlorpheniramine. Since DXR-induced chronic cardiomyopathy also seems to be related to the same mechanisms involved in the onset of acute cardiac effects induced by this drug, additional studies were …