0000000000073121
AUTHOR
Marcela Drechslerova
Approaches for the introduction of fluorinated substituents into [1,2,3]Triazolo[1,5-a]pyridines
Abstract [1,2,3]Triazolo[1,5-a]pyridines functionalization with a trifluoromethyl group has been achieved for the first time using different synthetic strategies. Furthermore, these scaffolds have been employed as starting material in the synthesis of new 2,6-disubstituted pyridines containing the trifluoromethyl group, compounds that are not available using other methodologies. A fluorine-mediated triazolopyridine dimerisation is described, improving the previously known synthetic method. Preliminary studies focused on exploring triazolopyridines reactivity with electrophilic fluorine have revealed a new approach for the obtainment of imidazopyridines.
ChemInform Abstract: Approaches for the Introduction of Fluorinated Substituents into [1,2,3]Triazolo[1,5-a]pyridines.
Functionalization of [1,2,3]triazolo[1,5-a]pyridines with a trifluoromethyl group is achieved for the first time.