0000000000073121

AUTHOR

Marcela Drechslerova

showing 2 related works from this author

Approaches for the introduction of fluorinated substituents into [1,2,3]Triazolo[1,5-a]pyridines

2014

Abstract [1,2,3]Triazolo[1,5-a]pyridines functionalization with a trifluoromethyl group has been achieved for the first time using different synthetic strategies. Furthermore, these scaffolds have been employed as starting material in the synthesis of new 2,6-disubstituted pyridines containing the trifluoromethyl group, compounds that are not available using other methodologies. A fluorine-mediated triazolopyridine dimerisation is described, improving the previously known synthetic method. Preliminary studies focused on exploring triazolopyridines reactivity with electrophilic fluorine have revealed a new approach for the obtainment of imidazopyridines.

TrifluoromethylOrganic Chemistrychemistry.chemical_elementBiochemistryCombinatorial chemistryInorganic Chemistrychemistry.chemical_compoundchemistryGroup (periodic table)ElectrophileFluorineEnvironmental ChemistrySurface modificationReactivity (chemistry)TriazolopyridinePhysical and Theoretical ChemistryJournal of Fluorine Chemistry
researchProduct

ChemInform Abstract: Approaches for the Introduction of Fluorinated Substituents into [1,2,3]Triazolo[1,5-a]pyridines.

2014

Functionalization of [1,2,3]triazolo[1,5-a]pyridines with a trifluoromethyl group is achieved for the first time.

chemistry.chemical_compoundTrifluoromethylchemistryGroup (periodic table)Triazole derivativesSurface modificationOrganic chemistryGeneral MedicineChemInform
researchProduct