Additional file 2: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PR…

2017

Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (PDF 122 kb).

Additional file 1: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PR…

2017

PROBESE Study protocol version 2.5. This PDF file includes the most recent version of the PROBESE Study protocol with changes highlighted. (PDF 870Â kb)

Alternative Beatmungstechniken: IPPV, CPAP oder O 2 -Insufflation

2003

Tierexperimentelle Untersuchungen bieten Hinweise auf Vorteile von nichtphasischen Beatmungsstrategien gegenuber konventionellen Methoden.Diese Vorteile beziehen sich auf die geringere Traumatisierung der Lunge, die bessere Ventilation mit verbesserter Oxygenierung und CO2-Elimination sowie auf Vorteile in der systemischen und pulmonalen Hamodynamik.Noch besteht hinsichtlich alternativer Beatmungsstrategien wahrend der kardiopulmonalen Reanimation wie dem kontinuierlichen positiven Atemwegsdruck und der transtrachealen Sauerstoffinsufflation jedoch noch erheblicher Forschungsbedarf. Dabei kann in Zukunft die dynamische Computertomographie helfen, die Lungenbeluftung wahrend Reanimation darz…

Additional file 4: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PR…

2017

Standard operating procedures (SOP) for plasma Sampling. (PDF 115Â kb)

Additional file 1: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PR…

2017

PROBESE Study protocol version 2.5. This PDF file includes the most recent version of the PROBESE Study protocol with changes highlighted. (PDF 870Â kb)

Additional file 3: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PR…

2017

PROBESE case report form version 1.2.2. This file corresponds to the paper version of the case report form. (DOC 1610 kb).

Additional file 2: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PR…

2017

Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (PDF 122 kb).

Additional file 5: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PR…

2017

Standard operating procedures (SOP) for plasma Sampling. (PDF 110Â kb)

Additional file 3: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PR…

2017

PROBESE case report form version 1.2.2. This file corresponds to the paper version of the case report form. (DOC 1610 kb).

Overview of the pathology of three widely used animal models of acute lung injury

2007

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of acute diffuse damage to the pulmonary parenchyma by a variety of local or systemic insults. Increased alveolar capillary membrane permeability was recognized as the common end organ injury and a central feature in all forms of ALI/ARDS. Although great strides have been made in understanding the pathogenesis of ALI/ARDS and in intensive care medicine, the treatment approach to ARDS is still relying on ventilatory and cardiovascular support based on the recognition of the clinical picture. In the course of evaluating novel treatment approaches to ARDS, 3 models of ALI induced in different species, i.e. the…

Erratum: Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): Study…

2017

Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol…

2017

Background Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients. Methods/design The PRotective Ventilation with Higher versus Lower PEEP during General Anesthesia for Surgery in OBESE Patients (PROBESE) study is a multice…