0000000000076141
AUTHOR
Mario Ordóñez
Reactions of Piperazin-2-one, Morpholin-3-one, and Thiomorpholin-3-one with Triethyl Phosphite Prompted by Phosphoryl Chloride: Scope and Limitations
The reaction of the title lactams with triethyl phosphite prompted by phosphoryl chloride provided six-membered ring heterocyclic phosphonates or bisphosphonates. These novel scaffolds might be of interest as building blocks in medicinal chemistry. The course of the reaction was dependent on the structure of the used substrate. Thus, morpholin-3-one and thiomorpholin-3-one readily provided the corresponding 1,1-bisphosphonates (compounds 1, 2, 7, 14 and 16), whereas the protection of their nitrogen atom resulted in the formation of dehydrophosphonates (compounds 5, 6, and 8). Piperazin-2-one reacted differently yielding mixture of cis- and trans- piperazine-2,3-diyl-bisphosphonates (compoun…
CCDC 1888866: Experimental Crystal Structure Determination
Related Article: Rubén Oswaldo Argüello-Velasco, Błażej Dziuk, Bartosz Zarychta, Mario Ordóñez, Paweł Kafarski|2019|ACS Omega|4|9056|doi:10.1021/acsomega.9b01137
CCDC 1888865: Experimental Crystal Structure Determination
Related Article: Rubén Oswaldo Argüello-Velasco, Błażej Dziuk, Bartosz Zarychta, Mario Ordóñez, Paweł Kafarski|2019|ACS Omega|4|9056|doi:10.1021/acsomega.9b01137
CCDC 1888868: Experimental Crystal Structure Determination
Related Article: Rubén Oswaldo Argüello-Velasco, Błażej Dziuk, Bartosz Zarychta, Mario Ordóñez, Paweł Kafarski|2019|ACS Omega|4|9056|doi:10.1021/acsomega.9b01137
CCDC 1888867: Experimental Crystal Structure Determination
Related Article: Rubén Oswaldo Argüello-Velasco, Błażej Dziuk, Bartosz Zarychta, Mario Ordóñez, Paweł Kafarski|2019|ACS Omega|4|9056|doi:10.1021/acsomega.9b01137