0000000000076206

AUTHOR

Jennifer Meessen

showing 2 related works from this author

Albumin replacement therapy in immunocompromised patients with sepsis - Secondary analysis of the ALBIOS trial

2021

Abstract Background The best fluid replacement strategy and the role of albumin in immunocompromised patients with sepsis is unclear. Methods We performed a secondary analysis of immunocompromised patients enrolled in the ALBIOS trial which randomized patients with severe sepsis or septic shock to receive either 20% albumin (target 30 g per liter or more) and crystalloid or crystalloid alone during ICU stay. Results Of 1818 patients originally enrolled, 304 (16.4%) were immunocompromised. One-hundred-thirty-nine (45.7%) patients were randomized in the albumin while 165 (54.2%) in the crystalloid group. At 90 days, 69 (49.6%) in the albumin group and 89 (53.9%) in the crystalloids group died…

medicine.medical_specialtySepsimedicine.medical_treatmentSocio-culturaleCritical Care and Intensive Care MedicineSepsisAlbumin; Immunocompromised; Immunodeficiency; Sepsis; Septic shock03 medical and health sciencesImmunocompromised Host0302 clinical medicineInternal medicineSepsisAlbuminsSeptic shockmedicineHumansImmunodeficiencyRenal replacement therapyAlbumin; Immunocompromised; Immunodeficiency; Sepsis; Septic shock; Albumins; Crystalloid Solutions; Fluid Therapy; Humans; Immunocompromised Host; Sepsis; Shock SepticImmunocompromisedMechanical ventilationSeptic shockbusiness.industrySepticAlbuminHazard ratioAcute kidney injuryAlbumin030208 emergency & critical care medicineShockCrystalloid Solutionsmedicine.diseaseShock Septic030228 respiratory systemFluid TherapySOFA scorebusiness
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Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial

2021

Abstract Background The role of intravenous immunoglobulins (IVIG) during sepsis is controversial, as different trials on IVIG have observed inconsistent survival benefits. We aimed to elucidate the possible association and clinical significance between circulating levels of immunoglobulins. Methods In a subset of 956 patients with severe sepsis and septic shock of the multicentre, open-label RCT ALBIOS, venous blood samples were serially collected 1, 2, and 7 days after enrolment (or at ICU discharge, whichever came first). IgA, IgG and IgM concentrations were assayed in all patients on day 1 and in a subgroup of 150 patients on days 2 and 7. Ig concentrations were measured employing a tur…

medicine.medical_specialtySepsiIgGSecondary infectionCritical Care and Intensive Care MedicineGastroenterologylaw.inventionSepsisRandomized controlled triallawInternal medicineSepsisSeptic shockRisk of mortalitymedicineClinical significanceMortalitybusiness.industrySeptic shockRC86-88.9ResearchMedical emergencies. Critical care. Intensive care. First aidVenous bloodmedicine.diseaseIgM ImmunoglobulinsbusinessIgA; IgG; IgM Immunoglobulins; Mortality; Sepsis; Septic shockIgM ImmunoglobulinIgACohort study
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