0000000000077772

AUTHOR

M. Isabel Covas

showing 3 related works from this author

Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence

2013

OBJECTIVE Transcription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) on these associations are unknown. We investigated whether the TCF7L2-rs7903146 (C>T) polymorphism associations with type 2 diabetes, glucose, lipids, and cardiovascular disease incidence were modulated by MedDiet. RESEARCH DESIGN AND METHODS A randomized trial (two MedDiet intervention groups and a control group) with 7,018 participants in the PREvención con DIetaMEDiterránea study was undertaken and major cardiovascular events assessed. Data were analyzed at b…

Malemedicine.medical_specialtyCardiovascular and Metabolic RiskMediterranean dietEndocrinology Diabetes and MetabolismPopulationType 2 diabetesDiet MediterraneanGastroenterologylaw.inventionRandomized controlled triallawRisk FactorsDiabetes mellitusInternal medicineInternal MedicinemedicineOdds RatioHumanseducationTriglyceridesOriginal ResearchAgedAdvanced and Specialized Nursingeducation.field_of_studyPolymorphism Geneticbusiness.industryIncidenceHazard ratioOdds ratioFastingMiddle Agedmedicine.diseaseStrokeEndocrinologyDiabetes Mellitus Type 2Cardiovascular DiseasesFemalebusinessTCF7L2Transcription Factor 7-Like 2 ProteinDiabetes Care
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Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: Results from a randomized controlled trial

2013

[Background]: Hypertension can be prevented by adopting healthy dietary patterns. Our aim was to assess the 4-year effect on blood pressure (BP) control of a randomized feeding trial promoting the traditional Mediterranean dietary pattern.

MaleMediterranean diethumanosBlood PressureDiet Mediterraneanlaw.inventionRandomized controlled triallawNutsSingle-Blind MethodDietary patternsmediana edadMonounsaturated fatMedicine(all)Aged 80 and overancianoLow-fat dietSystolic blood presuredietaGeneral MedicineDietary patternMiddle AgedLow fat dietPrimary PreventionCardiovascular diseasesHypertensionSystolic blood pressureBlood pressureFemaleDietaaceites de plantasResearch Articlepresión sanguíneamétodo simple ciegomedicine.medical_specialtyestudios de casos y controlesControlled trial:Ciencias de la Salud::Nutrición y dietética [Materias Investigacion]Pressió sanguíniaMediterranean cookingInternal medicineMediterranean dietDiastolic blood pressureCuina mediterràniamedicineHumansPlant OilsAgedDiastolic blood presurebusiness.industryMalalties cardiovascularsCase-control studyPredimedSurgeryDietPREDIMED trialnuecesBlood pressureMulticenter studyCase-Control StudieshipertensiónbusinessOlive oil
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Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumption

2012

Background: Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other lifestyle factors is also not well understood. Objective: To investigate whether MC4R and FTO associations with body-weight are modulated by diet and physical activity (PA), and to study their association with alcohol and food intake. Methods: Adherence to Mediterranean diet (AdMedDiet) and physical activity (PA) were assessed by validated questionnaires in 7,052 high cardiovascular risk subjects. MC4R rs17782313 and FTO rs9939609 were determined. Independent and joint associati…

Maleconsumo de alcoholMediterranean dietEpidemiologyhumanoslcsh:MedicineMC4RCardiovascularSocial and Behavioral SciencesBody Mass IndexPsychologylcsh:ScienceBody mass indexmediana edadAged 80 and overancianoMultidisciplinaryMiddle AgedDrinking of alcoholic beveragesAlpha-Ketoglutarate-Dependent Dioxygenase FTOestilo de vidaMedicineReceptor Melanocortin Type 4Consum d'alcoholObesitatFemalePublic HealthFTOResearch Articlemedicine.medical_specialtyEstils de vidaWaistAlcohol DrinkingClinical Research DesignLifestylesAlpha-Ketoglutarate-Dependent Dioxygenase FTOExerciciBiologyInternal medicineDiabetes mellitusmedicineGenetic predispositionHumansObesitySports and Exercise MedicineLife StyleobesidadExercisePrimary CareNutritionAgedBehaviorPhysical activityproteínaslcsh:Ríndice de masa corporalProteinsnutritional and metabolic diseasesAnthropometrymedicine.diseaseObesityEndocrinologyMetabolic Disorderslcsh:QBody mass index
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