0000000000079562

AUTHOR

Jarmila Siegelová

showing 5 related works from this author

Prevention of apoptosis by deferoxamine during 4 hours of cold cardioplegia and reperfusion: in vitro study of isolated working rat heart model.

2002

INTRODUCTION: Heart transplantation is often accompanied by multiple functional alterations, especially in reperfusion period. These are probably related to the reactive oxygen species (ROS) formation catalyzed by transition metals such as iron and copper, and thus the preservation time of the donor hearts is limited. Metabolic protection of the heart grafts is a permanent objective of numerous experiments. Recently, an iron chelator deferoxamine (DFX) was proposed as antioxidant agent for storage solutions in heart grafts. Oxidative stress is also known to mediate the apoptotic cell death in different tissues during ischemia-reperfusion. METHODS: The aim of this study was to evaluate a pos…

medicine.medical_specialtyAntioxidantmedicine.medical_treatment030204 cardiovascular system & hematologyPharmacologymedicine.disease_causePathology and Forensic Medicine03 medical and health sciences0302 clinical medicinePhysiology (medical)Internal medicineHeart ratemedicine030304 developmental biologychemistry.chemical_classificationHeart transplantation0303 health sciencesReactive oxygen speciesbusiness.industry3. Good healthDeferoxaminemedicine.anatomical_structurechemistryVentricleApoptosisCardiologybusinessOxidative stressmedicine.drugPathophysiology : the official journal of the International Society for Pathophysiology
researchProduct

Electrical Stimulation of Skeletal Muscles An Alternative to Aerobic Exercise Training in Patients With Chronic Heart Failure?

2006

The aim of this study was to investigate whether electrical stimulation of skeletal muscles could represent a rehabilitation alternative for patients with chronic heart failure (CHF). Thirty patients with CHF and NYHA class II-III were randomly assigned to a rehabilitation program using either electrical stimulation of skeletal muscles or bicycle training. Patients in the first group (n = 15) had 8 weeks of home-based low-frequency electrical stimulation (LFES) applied simultaneously to the quadriceps and calf muscles of both legs (1 h/day for 7 days/week); patients in the second group (n = 15) underwent 8 weeks of 40 minute aerobic exercise (3 times a week). After the 8-week period signifi…

medicine.medical_specialtybusiness.industryStimulationGeneral Medicine030204 cardiovascular system & hematologymedicine.diseaseNyha classSurgeryCalf muscles03 medical and health sciences0302 clinical medicineBlood pressureHeart failureAnesthesiaMedicineAerobic exerciseIn patientCardiology and Cardiovascular MedicinebusinessExercise duration030217 neurology & neurosurgeryInternational Heart Journal
researchProduct

Low-Frequency Electrical Stimulation Increases Muscle Strength and Improves Blood Supply in Patients With Chronic Heart Failure

2005

This study was designed to evaluate the effects of low-frequency electrical stimulation (LFES) on muscle strength and blood flow in patients with advanced chronic heart failure (CHF).Patients with CHF (n=15; age 56.5 +/- 5.2 years; New York Heart Association III - IV; ejection fraction 18.7 +/- 3.3%) were examined before and after 6 weeks of LFES (10 Hz) of the quadriceps and calf muscles of both legs (1 h/day, 7 days/week). Dynamometry was performed weekly to determine maximal muscle strength (F(max); N) and isokinetic peak torque (PT(max); Nm); blood flow velocity (BFV) was measured at baseline and after 6 weeks of LFES using pulsed-wave Doppler velocimetry of the right femoral artery. Si…

Malemedicine.medical_specialtyStimulation030204 cardiovascular system & hematologyVentricular Function LeftBody Mass Index03 medical and health sciences0302 clinical medicineCoronary CirculationInternal medicineHumansMedicineIn patientMuscle SkeletalHeart FailureVentricular functionbusiness.industryHeartGeneral MedicineBlood flowMiddle Agedmedicine.diseaseElectric StimulationC-Reactive ProteinChronic diseaseHeart failureChronic DiseaseCardiologyMuscle strengthFemaleBlood supplyShear StrengthCardiology and Cardiovascular MedicinebusinessBiomarkersBlood Flow Velocity030217 neurology & neurosurgeryCirculation Journal
researchProduct

Melatonin protects against ischemia-reperfusion injury and inhibits apoptosis in isolated working rat heart.

2003

INTRODUCTION: Melatonin (MEL), a pineal hormone, is well known as a potent antioxidant in a variety of ischemia-reperfusion models. Recent studies have assumed a pivotal role of reactive oxygen species (ROS) in the development of apoptosis. There are few pieces of information concerning a possible protective role of MEL against apoptosis in ischemia-reperfusion injury of myocardium. METHODS: We conducted an in vitro experiment: (1) to study the effect of MEL in the model of isolated and perfused working rat heart; (2) to evaluate the antioxidant capacity of MEL by a simple fluorescence test; and (3) to analyze the extent of apoptosis inhibition by MEL. Four groups of male Wistar rat were us…

Antioxidantmedicine.medical_treatmentIschemiaPharmacologymedicine.disease_causePathology and Forensic MedicineMelatonin03 medical and health sciences0302 clinical medicinehemic and lymphatic diseasesPhysiology (medical)medicineneoplasms030304 developmental biologychemistry.chemical_classification0303 health sciencesReactive oxygen speciesTUNEL assaymedicine.disease3. Good healthchemistryApoptosisAnesthesiaReperfusion injury030217 neurology & neurosurgeryOxidative stressmedicine.drugPathophysiology : the official journal of the International Society for Pathophysiology
researchProduct

Intra-Dialytic Electrostimulation of Leg Extensors May Improve Exercise Tolerance and Quality of Life in Hemodialyzed Patients

2011

Hemodialyzed (HD) patients with end-stage renal disease (ESRD) exhibit lower fitness as a consequence of chronic uremic changes that trigger various structural, metabolic, and functional abnormalities in skeletal muscles. The aim of this randomized study was to compare the effect of rehabilitation (RHB) training on a bicycle ergometer and electromyostimulation (EMS) of leg extensors in HD patients with ESRD. Thirty-two HD patients (18 men/14 women; mean age 61.1 ± 8.8 years) were randomized into three groups: (i) exercise training (ET; n = 11) on bicycle ergometer 2 × 20 min; (ii) EMS (n = 11) where stimulation (10 Hz) of leg extensors was applied for 60 min; and (iii) controls (CON; n = 10…

medicine.medical_specialtymedicine.medical_treatment030232 urology & nephrologyBiomedical EngineeringMedicine (miscellaneous)Bioengineering030204 cardiovascular system & hematologylaw.inventionBiomaterials03 medical and health sciences0302 clinical medicineRandomized controlled trialQuality of lifelawInternal medicinemedicineProspective cohort studyWalking testbusiness.industryGeneral Medicinemedicine.diseaseUremiaMuscle atrophy3. Good healthCardiologyPhysical therapyBicycle ergometerHemodialysismedicine.symptombusinessArtificial Organs
researchProduct