0000000000083246

AUTHOR

Keely Joanne Brookes

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ADHD and DAT1: Further evidence of paternal over-transmission of risk alleles and haplotype

2010

Contains fulltext : 87259.pdf (Publisher’s version ) (Closed access) We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 3'-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3'-UTR VNTR, respectively) of DAT1. In addition, a similar pattern of over-transmission of paternal ri…

Untranslated region2716 Genetics (clinical)Candidate gene2804 Cellular and Molecular NeuroscienceMedizin610 Medicine & healthMinisatellite RepeatsBiology2738 Psychiatry and Mental HealthGenomic Imprinting03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineSDG 3 - Good Health and Well-beingmental disordersPerception and Action [DCN 1]HumansGenetics(clinical)ddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersRisk factorAllele3' Untranslated RegionsNuclear familyGeneAllelesGenetics (clinical)GeneticsMental Health [NCEBP 9]Dopamine Plasma Membrane Transport ProteinsHaplotypeIntron10058 Department of Child and Adolescent Psychiatry030227 psychiatryPsychiatry and Mental healthHaplotypesAttention Deficit Disorder with Hyperactivity/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being030217 neurology & neurosurgeryAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
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