0000000000083258

AUTHOR

Ziarih Hawi

showing 3 related works from this author

ADHD and DAT1: Further evidence of paternal over-transmission of risk alleles and haplotype

2010

Contains fulltext : 87259.pdf (Publisher’s version ) (Closed access) We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 3'-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3'-UTR VNTR, respectively) of DAT1. In addition, a similar pattern of over-transmission of paternal ri…

Untranslated region2716 Genetics (clinical)Candidate gene2804 Cellular and Molecular NeuroscienceMedizin610 Medicine & healthMinisatellite RepeatsBiology2738 Psychiatry and Mental HealthGenomic Imprinting03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineSDG 3 - Good Health and Well-beingmental disordersPerception and Action [DCN 1]HumansGenetics(clinical)ddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersRisk factorAllele3' Untranslated RegionsNuclear familyGeneAllelesGenetics (clinical)GeneticsMental Health [NCEBP 9]Dopamine Plasma Membrane Transport ProteinsHaplotypeIntron10058 Department of Child and Adolescent Psychiatry030227 psychiatryPsychiatry and Mental healthHaplotypesAttention Deficit Disorder with Hyperactivity/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being030217 neurology & neurosurgeryAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
researchProduct

Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth

2008

Contains fulltext : 70196.pdf (Publisher’s version ) (Closed access) Season of birth (SOB) has been associated with attention deficit hyperactivity disorder (ADHD) in two existing studies. One further study reported an interaction between SOB and genotypes of the dopamine D4 receptor (DRD4) gene. It is important that these findings are further investigated to confirm or refute the findings. In this study, we investigated the SOB association with ADHD in four independent samples collected for molecular genetic studies of ADHD and found a small but significant increase in summer births compared to a large population control dataset. We also observed a significant association with the 7-repeat…

MaleProbandLinkage disequilibriumSeason of birthGenetics and epigenetic pathways of disease [NCMLS 6]MedizinPhysiologyNeuroinformatics [DCN 3]Mental health [NCEBP 9]Linkage DisequilibriumGenomic disorders and inherited multi-system disorders [IGMD 3]03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineCognitive neurosciences [UMCN 3.2]mental disordersmedicineDopamine receptor D4Perception and Action [DCN 1]HumansAttention deficit hyperactivity disorderddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersAlleleGene–environment interactionChildAllelesGenetics (clinical)biologyReceptors Dopamine D4Parturitionmedicine.disease030227 psychiatry3. Good healthPsychiatry and Mental healthVariable number tandem repeatGenetic defects of metabolism [UMCN 5.1]Attention Deficit Disorder with HyperactivityChild Preschoolbiology.proteinFemaleSeasonsFunctional Neurogenomics [DCN 2]030217 neurology & neurosurgery
researchProduct

Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): analysis of data from the international multicenter ADHD genetics (IMAGE…

2008

Contains fulltext : 71540.pdf (Publisher’s version ) (Closed access) There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested…

ParentsCandidate geneGenetics and epigenetic pathways of disease [NCMLS 6]2804 Cellular and Molecular NeuroscienceMedizinNeuroinformatics [DCN 3]Linkage Disequilibrium2738 Psychiatry and Mental Health0302 clinical medicineRisk FactorsPerception and Action [DCN 1]Genetics(clinical)Genetics (clinical)0303 health sciencesTPH210058 Department of Child and Adolescent PsychiatryPsychiatry and Mental healthData Interpretation StatisticalFunctional Neurogenomics [DCN 2]Clinical psychologyGenetic Markers2716 Genetics (clinical)Single-nucleotide polymorphism610 Medicine & healthMental health [NCEBP 9]Polymorphism Single NucleotideGenetic determinismGenomic disorders and inherited multi-system disorders [IGMD 3]Molecular epidemiology [NCEBP 1]03 medical and health sciencesCellular and Molecular NeuroscienceCognitive neurosciences [UMCN 3.2]Translational research [ONCOL 3]medicineAttention deficit hyperactivity disorderHumansFamilyGenetic Predisposition to Diseaseddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersAlleleAlleles030304 developmental biologyChi-Square DistributionEndocrinology and reproduction [UMCN 5.2]business.industrymedicine.diseaseGenetic defects of metabolism [UMCN 5.1]Multicenter studyAttention Deficit Disorder with HyperactivityEtiologybusiness030217 neurology & neurosurgeryAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
researchProduct