Author: Timothy Slattery

0000000000084447

AUTHOR

Timothy Slattery

showing 3 related works from this author

RAGE Mediates a Novel Proinflammatory Axis

1999

S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci by a range of environmental cues. We report here that receptor for AGE (RAGE) is a central cell surface receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and related members of the S100/calgranulin superfamily. Interaction of EN-RAGEs with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Blockade of EN-RAGE/RAGE quenches delayed-type hypersensitivity and inflammatory colitis in murine models by arresting activation of central signaling pathw…

endocrine system diseasesbiologyBiochemistry Genetics and Molecular Biology(all)nutritional and metabolic diseasesInflammationS100A12 ProteinGeneral Biochemistry Genetics and Molecular BiologyCell biologyRAGE (receptor)Proinflammatory cytokineCell surface receptorImmunologycardiovascular systembiology.proteinmedicineCalgranulincardiovascular diseasesmedicine.symptomSignal transductionReceptorhuman activitiesCell

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Difficulties in extracting spatial information induce a bias towards the use of non-spatial heuristics in a spatial memory task: Poster

2021

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Difficulties in extracting spatial information induce a bias towards the use of non-spatial heuristics in a spatial memory task: Oral presentation

2021

spatial precisionspatial perspective takingspatial encoding

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PEPhysical Sciences and Engineering
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