Search for theX(4140)state inB+→J/ψϕK+decays

We investigate the decay B+ -> J/psi phi K+ in a search for the X(4140) state, a narrow threshold resonance in the J/psi phi system. The data sample corresponds to an integrated luminosity of 10.4 fb(-1) of p (p) over bar collisions at root s = 1.96 TeV collected by the D0 experiment at the Fermilab Tevatron collider. We observe a mass peak with a statistical significance of 3.1 standard deviations and measure its invariant mass to be M = 4159.0 +/- 4.3(stat) +/- 6.6(syst) MeV and its width to be Gamma = 19.9 +/- 12.6(stat)(-8.0)(+3.0)(syst) MeV.

Comparison of RNA-seq and microarray-based models for clinical endpoint prediction

Background Gene expression profiling is being widely applied in cancer research to identify biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool for transcriptome-based applications beyond the limitations of microarrays, we sought to systematically evaluate the performance of RNA-seq-based and microarray-based classifiers in this MAQC-III/SEQC study for clinical endpoint prediction using neuroblastoma as a model. Results We generate gene expression profiles from 498 primary neuroblastomas using both RNA-seq and 44 k microarrays. Characterization of the neuroblastoma transcriptome by RNA-seq reveals that more than 48,000 genes and 200,000 transcripts are being …

Termite Gut Symbiotic Archaezoa Are Becoming Living Metabolic Fossils

ABSTRACT Over the course of several million years, the eukaryotic gut symbionts of lower termites have become adapted to a cellulolytic environment. Up to now it has been believed that they produce nutriments using their own cellulolytic enzymes for the benefit of their termite host. However, we have now isolated two endoglucanases with similar apparent molecular masses of approximately 36 kDa from the not yet culturable symbiotic Archaezoa living in the hindgut of the most primitive Australian termite, Mastotermes darwiniensis . The N-terminal sequences of these cellulases exhibited significant homology to cellulases of termite origin, which belong to glycosyl hydrolase family 9. The corre…

May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension.

Abstract Aims Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. Methods and results Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and envi…

RHAMM/CD168 was defined as a LAA using the approach of serological screening of expression libraries (SEREX), eliciting IgG responses in 42% of patients with AML, but not in healthy volunteers (HV) or patients with autoimmune diseases. mRNA for RHAMM was demonstrated by qRT-PCR to be expressed in leukemic blasts of more than 80% of the AML patients, but not in PBMN or CD34+ stem cells of healthy volunteers. Among normal tissues, only testis, placenta and thymus showed significant mRNA expression for the antigen, therefore sharing the expression profile of some other SEREX antigens.

FGFR2mutation in 46,XY sex reversal with craniosynostosis

Patients with 46,XY gonadal dysgenesis (GD) exhibit genital anomalies, which range from hypospadias to complete male-to-female sex reversal. However, a molecular diagnosis is made in only 30% of cases. Heterozygous mutations in the human FGFR2 gene cause various craniosynostosis syndromes including Crouzon and Pfeiffer, but testicular defects were not reported. Here, we describe a patient whose features we would suggest represent a new FGFR2-related syndrome, craniosynostosis with XY male-to-female sex reversal or CSR. The craniosynostosis patient was chromosomally XY, but presented as a phenotypic female due to complete GD. DNA sequencing identified the FGFR2c heterozygous missense mutatio…

Search forZγevents with large missing transverse energy inpp¯collisions ats=1.96  TeV

We present the first search for new phenomena in Z gamma final states with large missing transverse energy using data corresponding to an integrated luminosity of 6.2 fb(-1) collected with the D0 experiment in p (p) over bar collisions at root s 1.96 TeV. This signature is predicted in gauge-mediated supersymmetry-breaking models, where the lightest neutralino (chi) over tilde (0)(1) is the next-to-lightest supersymmetric particle and is produced in pairs, possibly through decay from heavier supersymmetric particles. The (chi) over tilde (0)(1) can decay either to a Z boson or a photon and an associated gravitino that escapes detection. We exclude this model at the 95% C.L. for supersymmetr…

The Impact of Artificial Intelligence on Traditional Chinese Medicine

Traditional Chinese Medicine (TCM) is a well-established medical system with a long history. Currently, artificial intelligence (AI) is rapidly expanding in many fields including TCM. AI will significantly improve the reliability and accuracy of diagnostics, thus increasing the use of effective therapeutic methods for patients. This systematic review provides an updated overview on the major breakthroughs in the field of AI-assisted TCM four diagnostic methods, syndrome differentiation, and treatment. AI-assisted TCM diagnosis is mainly based on digital data collected by modern electronic instruments, which makes TCM diagnosis more quantitative, objective, and standardized. As a result, th…

Bacterial Ectosymbionts which Confer Motility: Mixotricha paradoxa from the Intestine of the Australian Termite Mastotermes darwiniensis

Measurement of the pp¯→W+b+X production cross section at s=1.96 TeV

We present a measurement of the cross section for $W$ boson production in association with at least one {$b$-quark} jet in proton-antiproton collisions. The measurement is made using data corresponding to an integrated luminosity of 6.1\ifb recorded with the D0 detector at the Fermilab Tevatron \ppbar Collider at $\sqrt{s}=1.96$ TeV. We measure an inclusive cross section of {$\sigma(W \sim(\to\mu\nu) + b + X) = 1.04 \pm 0.05\thinspace$(stat.) $\pm 0.12 \thinspace$(syst.) pb} and $\sigma(W (\to e\nu) + b + X) = 1.00$ \pm 0.04 \thinspace$(stat.) $\pm 0.12 \thinspace$(syst.) pb in the phase space defined by $p_T^\nu > 25$ GeV, $p_T^{\text{$b$-jet}}>20$ GeV, $|\eta^{\text{$b$-jet}}| 20$ GeV and…

Global analysis of data on the spin-orbit coupled $A^{1}\Sigma_{u}^{+}$ and $b^{3}\Pi_{u}$ states of Cs2

We present experimentally derived potential curves and spin-orbit interaction functions for the strongly perturbed $A^{1}\Sigma_{u}^{+}$ and $b^{3}\Pi_{u}$ states of the cesium dimer. The results are based on data from several sources. Laser-induced fluorescence Fourier transform spectroscopy (LIF FTS) was used some time ago in the Laboratoire Aim\'{e} Cotton primarily to study the $X ^{1}\Sigma_{g}^{+}$ state. More recent work at Tsinghua University provides information from moderate resolution spectroscopy on the lowest levels of the $b^{3}\Pi_{0u}^{\pm}$ states as well as additional high resolution data. From Innsbruck University, we have precision data obtained with cold Cs$_{2}$ molecu…

Graphab: A software dedicated to the modelling of landscape networks

International audience; Land cover changes resulting from urban sprawl, transport network intensification and agricultural changes contribute to fragment wildlife habitats and may lead to question viability of animal and plant populations. Landscape ecologists have shown that populations living in fragmented habitats are forced to adopt specific dynamics (patchy populations or metapopulations) making them highly dependent on fluxes between their habitat patches. Landscape connectivity may be defined as the functional response of a given species in terms of movement and individual fluxes to the potential links between habitat patches provided by the landscape structure.Many methods are used …

Graphab 2

For some ten years, landscape graphs have been widely used for modeling ecological networks and measuring landscape connectivity from an operational perspective. A landscape graph is a set of nodes (habitat patches for a given species or group species) potentially connected by links representing the functional connectivity between each pair of nodes. With their simple design and their ecological relevance, graph-based methods can serve as a guide for planning decision-making, especially for the conservation of ecological networks. In this perspective, Graphab 2 project aims to use landscape graphs to assess the impact of transport infrastructures on the functionality of ecological networks,…

Cellulose Digestion in the Termite Gut