Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins.

Human Hsp60 chaperonin and its bacterial homolog GroEL, in association with the corresponding co-chaperonins Hsp10 and GroES, constitute important chaperone systems promoting the proper folding of several mitochondrial proteins. Hsp60 is also currently described as a ubiquitous molecule with multiple roles both in health conditions and in several diseases. Naïve Hsp60 bearing the mitochondrial import signal has been recently demonstrated to present different oligomeric organizations with respect to GroEL, suggesting new possible physiological functions. Here we present a combined investigation with circular dichroism and small-angle X-ray scattering of structure, self-organization, and sta…

Leach-Proof Sol–Gel Microcapsules as Curing Agents for One-Pot Thermosetting Resins

The sol-gel microencapsulation of free-radical initiator benzoyl peroxide in sol-gel methyl-modified silica microcapsules of core/shell geometry allows curing of acrylate-based polyurethane and polyester resin formulations sprayed from a pressurized can without the need to compartmentalize reactants from the initiator to cross-link. These results open the route to widespread application of sol-gel microcapsules to efficiently cure polymer and composite mixtures that are widely used as functional coatings, molding compounds, adhesives, and sealants.

Techno-stressed Teachers are responsible for the digital divide? Gender differences in the perceived levels of Computer-anxiety, Computer-expertise, Computer self-efficacy and Internet attitudes of an Italian population

IEEE Std. 1459 power quantities ratio approaches for simplified harmonic emissions assessment

The paper investigates the suitability of using power ratio parameters for harmonic emissions assessment at the point of common coupling (PCC). The study is carried out starting from the IEEE Std. 1459-2010 apparent power decomposition, where power factors are defined for evaluating line utilization and harmonic pollution levels. In addition, the study investigates the behavior of new parameters, which are expressed in terms of ratio between IEEE Std. 1459-2010 power quantities. The study is carried out for both single-phase and three-phase case, also considering the presence of capacitors. ? 2018 IEEE.

GRB 101225A: an unusual stellar death on Christmas Day

Graph-theoretical derivation of brain structural connectivity

Brain connectivity at the single neuron level can provide fundamental insights into how information is integrated and propagated within and between brain regions. However, it is almost impossible to adequately study this problem experimentally and, despite intense efforts in the field, no mathematical description has been obtained so far. Here, we present a mathematical framework based on a graph-theoretical approach that, starting from experimental data obtained from a few small subsets of neurons, can quantitatively explain and predict the corresponding full network properties. This model also changes the paradigm with which large-scale model networks can be built, from using probabilisti…

Academic domains as political battlegrounds: A global enquiry by 99 academics in the fields of education and technology

WOS: 000401148100005

La sensibilità agli indizi semantici e alla struttura morfologica della parola: un confronto tra dislessici evolutivi e normolettori

EVpedia: a community web portal for extracellular vesicles research

Abstract Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. Results: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more tha…

Ultrapotassic volcanism from the waning stage of the Neotethyan subduction: a key study from the Izmir-Ankara-Erzincan suture belt, central northern Turkey

Upper Cretaceous volcano-sedimentary successions in the Central Pontides of Turkey, related to the closure of the Tethys Ocean, include a variety of alkaline ultrapotassic igneous rocks that have been classified as leucititic, lamprophyric and trachytic based on their mineral paragenesis. Although the ultrapotassic rocks display a range of K 2 O contents (0·9–8·4 wt %) that may partly reflect alteration processes, they display subduction-related trace element signatures characterized by significant enrichment of large ion lithophile elements and light rare earth elements relative to high field strength elements and heavy rare earth elements and depletion of Nb and Ta. However, their initial…

S-genotype identification, genetic diversity and structure analysis of Italian sweet cherry germplasm

In this study, 186 local sweet cherry accessions from 12 Italian regions, plus eight reference accessions, were analysed for the first time, using 13 microsatellite markers. Moreover, their S-incompatibility genotypes were identified with consensus primers for the S-RNase and SFB genes. A total of 161 unique genotypes were found; 18 groups of synonyms, along with the discovery of cases of misidentification. The average number of alleles per locus was 9.7, the mean expected heterozygosity (He) was 0.63, the mean observed heterozygosity (Ho) was 0.65 and the mean polymorphic information content (PIC) was 0.58. The structure analysis revealed the presence of six populations, which reflected in…

Measurement uncertainty impact on simplified load flow analysis in MV smart grids

This work is focused on the measurement uncertainty impact on load flow analysis in medium voltage (MV) distribution networks. In more detail, the paper presents the uncertainty evaluation of a simplified load flow algorithm, which is based on the load power measurements at each secondary substation and one voltage measurement at the slack bus (i.e. the voltage at the MV bus bars of the primary substation). To reduce the costs of the monitoring system, the load flow algorithm makes use of LV load power measurements for all the substations except those of MV users, where MV transducers are usually already installed. The uncertainties on the algorithm input quantities (load powers and slack b…

A single tube PCR assay for detecting viruses and their recombinants that cause tomato yellow leaf curl disease in Mediterranean basin

Tomato yellow leaf curl disease (TYLCD) is well known in Mediterranean countries, where it has been causing severe losses in tomato crops for decades. Until recently, two viruses (with several isolates) in the genus Begomovirus, family Geminiviridae, have been associated with the epidemics: Tomato yellow leaf curl virus (TYLCV) and Tomato yellow leaf curl Sardinia virus (TYLCSV). However, recombinants between these, such as Tomato yellow leaf curl Malaga virus (TYLCMalV), are spreading, and new methods for detecting all viruses present in the region are needed. By considering all DNA sequences available of viruses causing TYLCD in the Mediterranean basin, a PCR/RFLP protocol was developed t…

Ca-rich carbonates associated with ultrabasic-ultramafic melts. Carbonatite or limestone xenoliths? A case study from the late Miocene Morron de Villamayor volcano (Calatrava Volcanic Field, central Spain)

The volcanic products of the late Miocene Morron de Villamayor volcano (Calatrava Volcanic Field, central Spain) are known for being one of the few outcrops of leucitites in the entire circum-Mediterranean area. These rocks are important because aragonite of mantle origin has been reported as inclusion in olivine macrocrysts. We use petrographic observations, mineral compositions, as well as oxygen and carbon isotope ratios coupled with experimental petrology to understand the origin of carbonate phase in these olivine-phyric rocks. Groundmass and macrocryst olivines range from δ18OVSMOW of +4.8‰, typical of mantle olivine values, to +7.4‰, indicating contamination by sedimentary carbonate.…

Family reunification: the case of the Muslim migrant children in Europe

Adopting a child is not a legal concept recognized in Islamic law, who however giving a great importance to orphans and children's rights, has introduced the legal institute of the "Kafala". This institute can be defined as a commitment by the "kafil" to ensure maintenance, education and protection of a minor "makfoul" until his legal majority, in the same way as would a father to his son, but without creating any family relationship. For these reasons the “Kafala” can not be compared to an international adoption, which, contrariwise, entails the creation of a parent-child relationship. If, in one side the Kafala is a legal concept recognized by International Law, in particular by the Unite…

International Law, War and Human Rights: The Humanitarian Response

One of the most important issues in the international political and legal system comprises the interaction between human rights and humanitarian law. In particular, the separate treatment of such areas of law allows to delineate different contents and application procedures, while the joint consideration is not simple, in view of the reasons for which each of the two has been created. Humanitarian law is a set of rules of conduct limited to a political and legal situation pathological, and presumably temporary. Against this regulatory system, the international law of human rights is the establishment of a political and legal concept of man as endowed with certain inalienable rights that con…