Confirmatory factor analysis of the Patient Assessment of Constipation-Symptoms (PAC-SYM) among patients with chronic constipation.

Background and aim: PAC-SYM is widely adopted to asses constipation severity. However, it has been validated in a small sample, few items have been included based on expert opinion and not on empirical grounds, and its factor structure has never been replicated. We aimed at evaluating the psychometric properties of PAC-SYM in patients with chronic constipation. Methods: We enrolled 2,203 outpatients with chronic constipation in two waves. We used wave I sample to test the psychometric properties of the PAC-SYM and wave II sample to cross-validate its factor structure, to assess criterion validity, responsiveness to clinical change, and its minimal clinically important difference. Results: O…

Balsalazide and/or high-potency probiotic misture (VSL#3) in maintaining after attack of acute, uncomplicated diverticulitis of the colon

The clinical picture of uncomplicated versus complicated diverticulitis of the colon

Effect of lactoferrin supplementation on quadruple therapy after failure of a first attempt to cure Helicobacter pilori infection

Epithelial Cell Proliferation of the Colonic Mucosa in Defferent Degrees of Colonic Diverticular Disease