0000000000088279
AUTHOR
Christian D Siewert
Investigation of pH-Responsiveness inside Lipid Nanoparticles for Parenteral mRNA Application Using Small-Angle X-ray Scattering.
Messenger ribonucleic acid (mRNA)-based nanomedicines have shown to be a promising new lead in a broad field of potential applications such as tumor immunotherapy. Of these nanomedicines, lipid-based mRNA nanoparticles comprising ionizable lipids are gaining increasing attention as versatile technologies for fine-tuning toward a given application, with proven potential for successful development up to clinical practice. Still, several hurdles have to be overcome to obtain a drug product that shows adequate mRNA delivery and clinical efficacy. In this study, pH-induced changes in internal molecular organization and overall physicochemical characteristics of lipoplexes comprising ionizable li…
Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA
Cells 9(9), 2034 (1-19) (2020). doi:10.3390/cells9092034
Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems
Biomaterials 192, 612 - 620 (2019). doi:10.1016/j.biomaterials.2018.10.020