0000000000088906

AUTHOR

Rainer Dziewas

showing 4 related works from this author

Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre …

2021

Summary Background Systematic electrocardiogram (ECG) monitoring improves detection of covert atrial fibrillation in stroke survivors but the effect on secondary prevention is unknown. We aimed to assess the effect of systematic ECG monitoring of patients in hospital on the rate of oral anticoagulant use after 12 months. Methods In this investigator-initiated, randomised, open-label, parallel-group multicentre study with masked endpoint adjudication, we recruited patients aged at least 18 years with acute ischaemic stroke or transient ischaemic attack without known atrial fibrillation in 38 certified stroke units in Germany. Patients were randomly assigned (1:1) to usual diagnostic procedur…

Malemedicine.medical_specialtyepidemiology [Atrial Fibrillation]methods [Electrocardiography]Populationdiagnosis [Ischemic Stroke]030204 cardiovascular system & hematologyBrain Ischemia03 medical and health sciencesElectrocardiography0302 clinical medicineRisk FactorsInternal medicineIschaemic strokeAtrial Fibrillationdiagnosis [Brain Ischemia]medicineepidemiology [Brain Ischemia]HumansIn patientMyocardial infarctionddc:610educationepidemiology [Ischemic Stroke]Ischemic StrokeMonitoring PhysiologicAgedAged 80 and overeducation.field_of_studybusiness.industryphysiopathology [Ischemic Stroke]Hazard ratiodiagnosis [Atrial Fibrillation]Atrial fibrillationOdds ratioMiddle Agedmethods [Monitoring Physiologic]medicine.diseasephysiopathology [Atrial Fibrillation]physiopathology [Brain Ischemia]3. Good healthFemaleNeurology (clinical)Open labelbusiness030217 neurology & neurosurgery
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Increase of Substance P Concentration in Saliva after Pharyngeal Electrical Stimulation in Severely Dysphagic Stroke Patients – an Indicator of Decan…

2017

Background/Aims: Substance P (SP) is a neuropeptide, likely acting as a neurotransmitter in the pharyngeal mucosa enhancing the swallow and cough reflex. Pharyngeal Electrical Stimulation (PES) induces a temporary increase of salivary SP levels in healthy adults. Previous evidence suggests that post-stroke dysphagia is related to reduced SP levels. Here, we investigated the effects of PES on SP levels in severely dysphagic stroke patients and a possible link between increase of SP and treatment success. Methods: 23 tracheotomized stroke patients who could not be decannulated due to severe and persisting dysphagia according to endoscopic evaluation received PES for 10 minutes a day over thre…

MaleSalivaStroke patientCough reflexStimulationSubstance PSubstance Plcsh:RC346-42903 medical and health sciencesCellular and Molecular Neurosciencechemistry.chemical_compoundTracheostomy0302 clinical medicinePharyngeal electrical stimulationDevelopmental NeurosciencemedicineHumansProspective Studies030212 general & internal medicineSalivaStrokelcsh:Neurology. Diseases of the nervous systemAgedAged 80 and overbusiness.industrylcsh:QP351-495Middle Agedmedicine.diseaseDysphagiaElectric StimulationStrokePESlcsh:Neurophysiology and neuropsychologyNeurologychemistryAnesthesiaTracheal decannulationPharynxBiomarker (medicine)Femalemedicine.symptomDeglutition Disordersbusiness030217 neurology & neurosurgeryNeurosignals
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PB3. Pharyngeal Electrical Stimulation in neurointensive care patients suffering from severe post-stroke dysphagia – Post stimulation increase of sal…

2018

Introduction Dysphagia is one of the most important and prognostically relevant complications of acute stroke. Pharyngeal Electrical Stimulation (PES) is a treatment device that enhances cortical reorganization for the restoration of swallowing function after cerebral injury. Furthermore, it was shown that PES leads to a temporary increase of Substance P (SP) level in saliva but not serum in healthy adults. The neuropeptide SP likely acts as a neurotransmitter in the pharyngeal mucosa and enhances the swallow and cough reflex. Post-stroke dysphagia may be related to reduced SP-levels. Here, we investigated the association of PES treatment in neurointensive care patients suffering from sever…

Salivabusiness.industrymedicine.medical_treatmentCough reflexNeurointensive careStimulationDysphagiaSensory SystemsTracheotomyNeurologySwallowingPhysiology (medical)AnesthesiamedicineBiomarker (medicine)Neurology (clinical)medicine.symptombusinessClinical Neurophysiology
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Substance P Saliva Reduction Predicts Pharyngeal Dysphagia in Parkinson's Disease

2019

Introduction: Although patients with Parkinson's disease (PD) often suffer from oropharyngeal dysphagia, knowledge about the underlying pathophysiological mechanisms is limited. Substance P (SP) is a localization-independent neurotransmitter of the entire nervous system. Reduced levels of SP were found in saliva of patients with impaired cough reflex and in advanced stages of PD. The aim of the study was to investigate SP in PD patients in order to gain further insights into the underlying pathophysiology of PD-related dysphagia and to evaluate the potential of SP as a biomarker for early dysphagia. Methods: Flexible endoscopic evaluation of swallowing (FEES) was used to objectively assess …

medicine.medical_specialtySalivaParkinson's diseasedysphagiaCough reflexParkinson's diseasesubstance PGastroenterologylcsh:RC346-42903 medical and health sciences0302 clinical medicineSwallowingInternal medicinemedicineotorhinolaryngologic diseaseslcsh:Neurology. Diseases of the nervous system030304 developmental biologyOriginal Research0303 health sciencesbusiness.industryPharyngeal swallowingneurodegenerationmedicine.diseaseDysphagiaNeurologyBiomarker (medicine)biomarkerNeurology (clinical)medicine.symptombusiness030217 neurology & neurosurgeryOropharyngeal dysphagiaFrontiers in Neurology
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