0000000000089180
AUTHOR
Radosław Balwierz
Nanoparticles coated by chloramphenicol in hydrogels as a useful tool to increase the antibiotic release and antibacterial activity in dermal drug delivery
Abstract Background Nanocarriers for antibacterial drugs became hopeful tools against the increasing resistance of bacteria to antibiotics. This work focuses on a comprehensive study of the applicability and therapeutic suitability of dermal carbopol-based hydrogels containing chloramphenicol carried by various nanoparticles (AuNPs and SiNPs). Methods The different forms of carbopol-based drugs for dermal use were obtained. Five different concentrations of chloramphenicol and two types of nanoparticles (silica and gold) in carbopol-based ointments were tested. The influence of different carbopol formulations with nanocarriers on the rheological properties as well as the release profile of a…
Assessment of the moisturizing potential of a two-phase topical care product containing vegetable oils, glycerin, panthenol, and sodium hyaluronate - a preliminary studies
The presence of moisturizing substances and lipid substances determines the integrity of the epidermis cells and their barrier functions because it protects the interior of the body against environmental changes: temperature, humidity, ultraviolet radiation, pollution, and the effects of detergents. In this study, we performed a non-invasive, preliminary evaluation of the effects of a biphasic facial skin care product containing plant oils, hyaluronic acid, glycerin, and panthenol on skin hydration levels and transepidermal water loss compared to a control group using only shea butter. The topical care product formed as a two-phase emulsion was tested. The research was carried out with the …